4-phenylamino-naphthalen-1-ol | 55850-14-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-phenylamino-naphthalen-1-ol
• 英文别名: 4-Anilino-[1]naphthol；4-anilino-1-naphthol；4-anilinonaphthalen-1-ol
• CAS: 55850-14-1
• 化学式: C₁₆H₁₃NO
• 分子量: 235.285
• InChiKey: BQIUTGGBDPCMLT-UHFFFAOYSA-N

物化性质

• 熔点：
  92 °C
• 沸点：
  399.1±17.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-phenylamino-naphthalen-1-ol 在 air 作用下， 生成 4-苯基亚氨基萘-1-酮
  参考文献：
  名称：

  DE343057

  摘要：

  公开号：
• 作为产物：
  描述：

  4-methoxy-N-phenyl-1-naphthalenamine 在 三溴化硼 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 以88%的产率得到4-phenylamino-naphthalen-1-ol
  参考文献：
  名称：

  Design, Synthesis, and Structure–Activity Relationship of N-Arylnaphthylamine Derivatives as Amyloid Aggregation Inhibitors

  摘要：

  Dyes like CR are able to inhibit the aggregation of A beta fibrils. Thus, a screening of a series of dyes including ABBB (1) was performed. Its main component 2 tested in an in vitro assay (i.e., ThT assay) showed good potency at inhibiting fibrils association. Congeners 4-9 have been designed and synthesized as inhibitors of A beta aggregation. A nurnber of these newly synthesized compounds have been found to be active in the ThT assay with IC50 of 1-57.4 mu M. The most potent compound of this series, 4k, showed micromolar activity in this test. Another potent derivative 4q (IC50 = 5.6 mu M) rapidly crossed the blood-brain barrier, achieving whole brain concentrations higher than in plasma. So 4q could be developed to find novel potent antiaggregating beta A agents useful in Alzheimer disease as well as other neurological diseases characterized by deposits of amyloid aggregates.

  DOI：

  10.1021/jm301105m

文献信息

• Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation
  申请人：Minetti Patrizia

  公开号：US20080255232A1

  公开（公告）日：2008-10-16

  Compounds useful in the treatment of disorders characterized by deposits of amyloid aggregates are herein described together with pharmaceutical compounds containing the same. In particular the compounds of the present invention are those having the Formula (I) as reported below, where the radicals have the meaning indicated in the description.

  本文描述了用于治疗由淀粉样聚集物沉积所特征化的疾病的化合物，以及含有相同化合物的药物化合物。特别是，本发明的化合物是具有下面报告的式（I）的化合物，其中基团具有描述中所示的含义。
• WO2007/45593
  申请人：——

  公开号：——

  公开（公告）日：——
• Sander, Chemische Berichte, 1925, vol. 58, p. 833
  作者：Sander

  DOI：——

  日期：——
• DE343057
  申请人：——

  公开号：——

  公开（公告）日：——
• Friedlaender, Justus Liebigs Annalen der Chemie, 1925, vol. 443, p. 223
  作者：Friedlaender

  DOI：——

  日期：——