摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

2-azabicyclo[2.2.2]octene | 95673-69-1

中文名称
——
中文别名
——
英文名称
2-azabicyclo[2.2.2]octene
英文别名
Azabicyclo[2.2.2]octene;2-azabicyclo[2.2.2]oct-1-ene
2-azabicyclo[2.2.2]octene化学式
CAS
95673-69-1
化学式
C7H11N
mdl
——
分子量
109.171
InChiKey
OIUARUPERKJHFP-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.3
  • 重原子数:
    8
  • 可旋转键数:
    0
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.86
  • 拓扑面积:
    12.4
  • 氢给体数:
    0
  • 氢受体数:
    1

反应信息

点击查看最新优质反应信息

文献信息

  • [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DE STABILISATION DE LA TRANSTHYRÉTINE ET D'INHIBITION DU MAUVAIS REPLIEMENT DE LA TRANSTHYRÉTINE
    申请人:PROTEGO BIOPHARMA INC
    公开号:WO2021154842A1
    公开(公告)日:2021-08-05
    Provided herein are compounds having activity against TTR related conditions, and pharmaceutically accepted salts and solvates thereof. Also provided are methods of using the compounds for inhibiting and preventing TTR aggregation and/or amyloid formation in the peripheral nerves, kidney, cardiac tissue, eye and CNS, and of treating a subject with peripheral TTR amyloidosis.
    本文件提供了对TTR相关疾病具有活性的化合物,以及可被药物接受的盐和溶剂化物。还提供了使用这些化合物来抑制和预防外周神经、肾脏、心肌组织、眼睛和中枢神经系统的TTR聚集和/或淀粉样蛋白形成的方法,以及治疗患有外周TTR淀粉样变性的主体的方法。
  • [EN] PYRIMIDINYLPYRAZOLES AS TGF-BETA INHIBITORS<br/>[FR] PYRIMIDINYLPYRAZOLES UTILISES COMME INHIBITEURS DE TGF-BETA
    申请人:BIOGEN IDEC INC
    公开号:WO2006026305A1
    公开(公告)日:2006-03-09
    The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).
    这项发明是基于发现,式(I)的化合物具有与Alk 5和/或Alk 4的高亲和力,并可用作其拮抗剂,用于预防和/或治疗包括纤维化疾病在内的许多疾病。该发明涉及式(I)的化合物及其用途:式(I)。
  • Process for the preparation of aminoalcohol derivatives and their further conversion to (1R, 4S)-4-((2-amino-6-chloro-5-formamido-4-pyrimidinyl)-amino)-2-cyclopentenyl-1- methanol
    申请人:Lonza AG
    公开号:US20020010360A1
    公开(公告)日:2002-01-24
    The invention relates to a novel process for the preparation of an aminoalcohol of the formula 1 racemically or optically active, starting from 2-azabi-cyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulae 2 In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl) formamide of the formula 3 to give (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulae 4 and then cyclized to give the end compounds.
    该发明涉及一种新颖的方法,用于制备公式1的氨基醇,其为外消旋或光学活性,从2-azabi-cyclo[2.2.1]hept-5-en-3-one出发,进一步转化为相应的酰基衍生物,再进一步转化为公式2中的(1S,4R)-或(1R,4S)-4-(2-氨基-6-氯-9-H-嘌呤-9-基)-2-环戊烯基-1-甲醇。在后一合成中,氨基醇转化为相应的D-或L-酒石酸盐,然后与公式3中的N-(2-氨基-4,6-二氯嘧啶-5-基)甲酰胺反应,以得到公式4中的(1S,4R)-或(1R,4S)-4-(2-氨基-6-氯-5-甲酰胺基-4-嘧啶基)氨基-2-环戊烯基-1-甲醇,然后进行环化反应以得到最终的化合物。
  • Process for the preparation of aminoalcohol derivatives and their further conversion to (1R,4S)-4-(2-amino-6-chloro-5-formamido-4-pyrimidinyl)-amino)-2-cyclopentenyl-1-methanol
    申请人:——
    公开号:US20040142436A1
    公开(公告)日:2004-07-22
    The invention relates to a novel process for the preparation of an aminoalcohol of the formula 1 racemically or optically active, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulae 2 In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl) form amide of the formula 3 to give (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulae 4 and then cyclized to give the end compounds.
    本发明涉及一种从2-氮杂双环[2.2.1]庚-5-烯-3-酮出发制备公式1的氨基醇的新工艺,其进一步转化为相应的酰基衍生物,并进一步转化为公式2的(1S,4R)-或(1R,4S)-4-(2-氨基-6-氯-9-H-嘌呤-9-基)-2-环戊基-1-甲醇。在后一种合成中,氨基醇转化为相应的D-或L-酒石酸盐,然后与公式3的N-(2-氨基-4,6-二氯嘧啶-5-基)甲酰胺反应,以给出公式4的(1S,4R)-或(1R,4S)-4-[(2-氨基-6-氯-5-甲酰基-4-嘧啶基)氨基]-2-环戊基-1-甲醇,然后环化以得到最终产物。
  • PROCESS FOR THE PREPARATION OF AMINOALCOHOL DERIVATIVES AND THEIR FURTHER CONVERSION TO (1R, 4S)-4(2-AMINO-6-CHLORO-5-FORMAMIDO-4- PYRIMIDINYL)-AMINO-2-CYCLOPENTENYL-1-METHANOL
    申请人:Brieden Walter
    公开号:US20060211862A1
    公开(公告)日:2006-09-21
    The invention relates to a novel process for the preparation of an aminoalcohol of the formula racemically or optically active, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)- or ( 1 R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulae In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl) formamide of the formula to give (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulae and then cyclized to give the end compounds.
    本发明涉及一种新型的制备氨基醇的方法,该氨基醇的结构式为,可以是外消旋或内消旋,从2-氮杂双环[2.2.1]庚-5-烯-3-酮开始,进一步转化为相应的酰基衍生物,然后进一步转化为(1S,4R)-或(1R,4S)-4-(2-氨基-6-氯-9-H-嘌呤-9-基)-2-环戊烯基-1-甲醇,其结构式为。在后一种合成中,氨基醇转化为相应的D-或L-酒石酸盐,然后与N-(2-氨基-4,6-二氯嘧啶-5-基)甲酰胺反应,其结构式为,以给出(1S,4R)-或(1R,4S)-4-[(2-氨基-6-氯-5-甲酰基-4-嘧啶基)氨基]-2-环戊烯基-1-甲醇,其结构式为,然后环化以得到最终化合物。
查看更多

同类化合物

(S)-氨氯地平-d4 (R,S)-可替宁N-氧化物-甲基-d3 (R)-N'-亚硝基尼古丁 (5E)-5-[(2,5-二甲基-1-吡啶-3-基-吡咯-3-基)亚甲基]-2-亚磺酰基-1,3-噻唑烷-4-酮 (5-溴-3-吡啶基)[4-(1-吡咯烷基)-1-哌啶基]甲酮 (5-氨基-6-氰基-7-甲基[1,2]噻唑并[4,5-b]吡啶-3-甲酰胺) (2S)-2-[[[9-丙-2-基-6-[(4-吡啶-2-基苯基)甲基氨基]嘌呤-2-基]氨基]丁-1-醇 (2R,2''R)-(+)-[N,N''-双(2-吡啶基甲基)]-2,2''-联吡咯烷四盐酸盐 黄色素-37 麦斯明-D4 麦司明 麝香吡啶 鲁非罗尼 鲁卡他胺 高氯酸N-甲基甲基吡啶正离子 高氯酸,吡啶 高奎宁酸 马来酸溴苯那敏 马来酸左氨氯地平 顺式-双(异硫氰基)(2,2'-联吡啶基-4,4'-二羧基)(4,4'-二-壬基-2'-联吡啶基)钌(II) 顺式-二氯二(4-氯吡啶)铂 顺式-二(2,2'-联吡啶)二氯铬氯化物 顺式-1-(4-甲氧基苄基)-3-羟基-5-(3-吡啶)-2-吡咯烷酮 顺-双(2,2-二吡啶)二氯化钌(II) 水合物 顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 顺-二氯二(吡啶)铂(II) 顺-二(2,2'-联吡啶)二氯化钌(II)二水合物 非那吡啶 非洛地平杂质C 非洛地平 非戈替尼 非尼拉朵 非尼拉敏 阿雷地平 阿瑞洛莫 阿培利司N-6 阿伐曲波帕杂质40 间硝苯地平 间-硝苯地平 锇二(2,2'-联吡啶)氯化物 链黑霉素 链黑菌素 银杏酮盐酸盐 铬二烟酸盐 铝三烟酸盐 铜-缩氨基硫脲络合物 铜(2+)乙酸酯吡啶(1:2:1) 铁5-甲氧基-6-甲基-1-氧代-2-吡啶酮 钾4-氨基-3,6-二氯-2-吡啶羧酸酯 钯,二氯双(3-氯吡啶-κN)-,(SP-4-1)-