2-<2-Diisopropylamino-aethoxy>-aethanol | 91819-36-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-<2-Diisopropylamino-aethoxy>-aethanol
• 英文别名: 2-(2-diisopropylamino-ethoxy)-ethanol；2-{2-[Bis(propan-2-yl)amino]ethoxy}ethan-1-ol；2-[2-[di(propan-2-yl)amino]ethoxy]ethanol
• CAS: 91819-36-2
• 化学式: C₁₀H₂₃NO₂
• 分子量: 189.298
• InChiKey: ZSURFYQYXOOOQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  10H-吡啶并[3,2-b][1,4]苯并噻嗪-10-甲酰氯 、 2-<2-Diisopropylamino-aethoxy>-aethanol 以 氯苯 为溶剂， 生成 benzo[b]pyrido[2,3-e][1,4]thiazine-10-carboxylic acid 2-(2-diisopropylamino-ethoxy)-ethyl ester
  参考文献：
  名称：

  Schuler,W.A. et al., Justus Liebigs Annalen der Chemie, 1964, vol. 673, p. 102 - 112

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-氯乙氧基)乙酸乙酯 、 二异丙胺 以 乙醇 为溶剂， 生成 2-<2-Diisopropylamino-aethoxy>-aethanol
  参考文献：
  名称：

  CARISSIMI; CATTANEO; D'AMBROSIO, Farmaco, Edizione Scientifica, 1963, vol. 18, p. 315 - 345

  摘要：

  DOI：
• 作为试剂：
  描述：

  1-氯酞嗪 、 alkaline earth salt of/the/ methylsulfuric acid 在 2-<2-Diisopropylamino-aethoxy>-aethanol 作用下， 生成 1-[2-(2-diisopropylamino-ethoxy)-ethoxy]-phthalazine
  参考文献：
  名称：

  SOME BASIC DERIVATIVES OF 6-CHLOROQUINAZOLINE AND PHTHALAZINE

  摘要：

  已合成6-氯喹噁啉和邻苯二氮杂环的基本衍生物，并对其在中枢神经系统上的生理作用进行了筛选。分别将氯苯二氮杂环和适当的氯苯二氮杂环与钠二烷氧基烷氧化物反应，得到了6-氯喹噁啉和邻苯二氮杂环的基本醚化合物。还制备了1-(γ-二甲氨基丙基氨基)邻苯二氮杂环。

  DOI：

  10.1139/v56-203

文献信息

• Processes for the preparation of hydroxyl-containing compounds
  申请人：UNION CARBIDE CHEMICALS AND PLASTICS COMPANY, INC.

  公开号：EP0478076A2

  公开（公告）日：1992-04-01

  A process for preparing hydroxyl-containing compounds which comprises contacting a carboxylated hydroxyl-containing compound with a metal oxide catalyst under conditions effective to produce the hydroxyl-containing compound.

  一种制备含羟基化合物的工艺，包括将羧化的含羟基化合物与金属氧化物催化剂在有效的条件下接触，以产生含羟基化合物。
• Amine-containing lipids and uses thereof
  申请人：Anderson Daniel G.

  公开号：US20110009641A1

  公开（公告）日：2011-01-13

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110052673A1

  公开（公告）日：2011-03-03

  Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
• DISULFIDE COMPOUNDS FOR DELIVERY OF PHARMACEUTICAL AGENTS
  申请人：XU Qiaobing

  公开号：US20160009643A1

  公开（公告）日：2016-01-14

  A compound of formula the following formula: (I). In this formula, moieties A, B, X, R 1 , R 2 , and R 3 are defined herein. Also disclosed are a nanocomplex that is formed of such a compound and a pharmaceutical agent, and a nanocomplex that is formed of a protein and a bioreducible compound.
• AMINE-CONTAINING LIPIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160009657A1

  公开（公告）日：2016-01-14

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.