dimethyl-[1-methyl-2-(2-trifluoromethyl-phenothiazin-10-yl)-ethyl]-amine | 3852-92-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: dimethyl-[1-methyl-2-(2-trifluoromethyl-phenothiazin-10-yl)-ethyl]-amine
• 英文别名: dimethyl-[β-(2-trifluoromethyl-phenothiazin-10-yl)-isopropyl]-amine；Dimethyl-[β-(2-trifluormethyl-phenothiazin-10-yl)-isopropyl]-amin；N,N-dimethyl-1-[2-(trifluoromethyl)phenothiazin-10-yl]propan-2-amine
• CAS: 3852-92-4
• 化学式: C₁₈H₁₉F₃N₂S
• 分子量: 352.423
• InChiKey: OSNBOVGWYCFZQP-UHFFFAOYSA-N

物化性质

• 沸点：
  419.2±45.0 °C(Predicted)
• 密度：
  1.237±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  31.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  间三氟甲基二苯胺 在 碘 、 sulfur 作用下， 生成 dimethyl-[1-methyl-2-(2-trifluoromethyl-phenothiazin-10-yl)-ethyl]-amine
  参考文献：
  名称：

  Yale et al., Journal of the American Chemical Society, 1957, vol. 79, p. 4375,4377

  摘要：

  DOI：

文献信息

• SINGLE PHENOTHIAZINE ENANTIOMERS AS AGENTS FOR THE PREVENTION OF BONE LOSS
  申请人：McDonough Joseph

  公开号：US20100285087A1

  公开（公告）日：2010-11-11

  Enantomerically purified phenothiazines are provided as active ingredients of medicaments to limit activity of bone resorbing cells so as to reduce bone loss. Novel phenothiazine derivatives are provided. A method of synthesizing enantiomerically pure phenothiazine derivatives is provided that avoids post-synthetic enantiomeric resolution.

  提供了对映纯的苯并噻嗪作为药物的活性成分，以限制骨吸收细胞的活动，从而减少骨质流失。提供了新颖的苯并噻嗪衍生物。提供了一种合成对映纯苯并噻嗪衍生物的方法，避免了后合成对映异构体的分离。
• Compositions and methods of modulating HIF-2A to improve muscle generation and repair
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US10953036B2

  公开（公告）日：2021-03-23

  Compositions and methods for modulating HIF-2α to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2α inhibitor. The HIF-2α inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.

  本研究提供了调节 HIF-2α 以调解卫星细胞中缺氧信号传导的组合物和方法及其在改善骨骼肌生成和修复中的应用。例如，公开了增强、增加、加速或/和以其他方式改善有需要的受试者的骨骼肌生成或再生的方法。在一些实施方案中，这些方法包括向受试者施用有效量的 HIF-2α 抑制剂。例如，HIF-2α抑制剂可有效增加受试者体内肌肉卫星细胞的增殖、分化或其组合。还提供了用于改善呼吸、减少或预防纤维化的发生或发展的组合物和方法。所公开的组合物和方法特别适用于治疗肌肉萎缩症、肌病和其他肌肉相关疾病和失调。
• TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS
  申请人：Arbiser Jack L.

  公开号：US20090176745A1

  公开（公告）日：2009-07-09

  Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.
• COMPOSITIONS AND METHODS OF MODULATING HIF-2A; TO IMPROVE MUSCLE GENERATION AND REPAIR
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US20190151347A1

  公开（公告）日：2019-05-23

  Compositions and methods for modulating HIF-2α to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2α inhibitor. The HIF-2α inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.
• COMPOSITIONS AND METHODS OF MODULATING HIF-2A TO IMPROVE MUSCLE GENERATION AND REPAIR
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US20210169920A1

  公开（公告）日：2021-06-10

  Compositions and methods for modulating HIF-2α to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2α inhibitor. The HIF-2α inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.