1-丙酰吡咯烷-2-酮 | 77015-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-丙酰吡咯烷-2-酮
• 英文名称: 1-propionyl-pyrrolidin-2-one
• 英文别名: 1-Propionyl-pyrrolidin-2-on；N-propanoyl pyrrolidone；N-Propionyl-pyrrolidon-(2)；N-Propionyl-2-pyrrolidon；1-Propanoylpyrrolidin-2-one
• CAS: 77015-41-9
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: MNRCYXHUPGJXOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933790090

反应信息

• 作为反应物：
  描述：

  1-丙酰吡咯烷-2-酮 在 calcium oxide 作用下， 生成 5-乙基-3,4-二氢-2H-吡咯
  参考文献：
  名称：

  Ananthapadmanabhan, S.; Raja, T. K.; Srinivasan, V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, p. 580

  摘要：

  DOI：
• 作为产物：
  描述：

  1-pyrrolidin-1-yl-propan-1-one 在 氧气 、 dioxide titanium 作用下， 以 水 为溶剂， 反应 48.0h， 以0.6 mmol的产率得到1-丙酰吡咯烷-2-酮
  参考文献：
  名称：

  Photocatalytic oxidations of lactams and N-acylamines

  摘要：

  DOI：

  10.1021/ja00412a043

文献信息

• Preparation of amides
  申请人：Shell Oil Company

  公开号：US05128475A1

  公开（公告）日：1992-07-07

  A process for the preparation of an amide, which comprises reacting an acetylenically or olefinically unsaturated compound with carbon monoxide and a nitrogen compound selected from ammonia and a primary or secondary amine or amide, in the presence of a catalyst system which comprises: a) a source of a Group VIII metal, b) a phosphine having an aromatic substituent which contains an imino nitrogen atom, and c) a protonic acid.

  制备酰胺的方法包括将乙炔基或烯基不饱和化合物与一氧化碳和氨或一级或二级胺或酰胺中选择的氮化合物反应，在催化剂系统的存在下进行，该催化剂系统包括：a）一种含有第VIII族金属的来源，b）具有芳香取代基的膦化合物，其中包含一个亚胺氮原子，以及c）一种质子酸。
• CuCl/TMEDA/nor-AZADO-catalyzed aerobic oxidative acylation of amides with alcohols to produce imides
  作者：Kengo Kataoka、Keiju Wachi、Xiongjie Jin、Kosuke Suzuki、Yusuke Sasano、Yoshiharu Iwabuchi、Jun-ya Hasegawa、Noritaka Mizuno、Kazuya Yamaguchi

  DOI：10.1039/c8sc01410h

  日期：——

  Although aerobic oxidative acylation of amides with alcohols would be a good complement to classical synthetic methods for imides (e.g., acylation of amides with activated forms of carboxylic acids), to date, there have been no reports on oxidative acylation to produce imides. In this study, we successfully developed, for the first time, an efficient method for the synthesis of imides through aerobic oxidative acylation

  尽管酰胺与醇的有氧氧化酰化是对酰亚胺的经典合成方法（例如，用活化形式的羧酸酰化酰胺）的良好补充，但迄今为止，还没有关于氧化酰化生产酰亚胺的报道。在本研究中，我们首次成功开发了一种采用 CuCl/TMEDA/nor-AZADO 催化剂体系（TMEDA = 四甲基乙二胺；nor-AZADO = 9-氮杂金刚烷N-氧基)。所提出的酰化通过以下顺序反应进行：醇有氧氧化成醛，酰胺与醛亲核加成形成半酰胺中间体，以及半酰胺中间体有氧氧化得到相应的酰亚胺。该催化系统利用O 2作为终端氧化剂并产生水作为唯一的副产物。实现这种有效酰化系统的一个重要点是TMEDA配体的利用，据我们所知，该配体尚未在之前报道的Cu/配体/ N-氧基系统中使用。基于实验证据，我们认为 TMEDA 的可能作用包括促进半酰胺氧化和从 Cu I物种再生活性 Cu II -OH 物种。这里促进半酰胺氧化尤其重要。利用所提出的系统，可以从醇
• TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME
  申请人：Corsair Pharma, Inc.

  公开号：US20150166503A1

  公开（公告）日：2015-06-18

  Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

  式子 I、II、III 和 IV 所代表的化合物包括替前列环素和前列环素类似物的前药。用途包括治疗肺高压（PH）或肺动脉高压（PAH）。这些化合物的结构可以根据适当的治疗剂量适应特定的应用。可以使用经皮应用。
• Phenyl-thiophene type vitamin D receptor modulators
  申请人：Eli Lilly & Company

  公开号：EP2184281A1

  公开（公告）日：2010-05-12

  The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

  本发明涉及具有维生素 D 受体（VDR）调节活性的新型非甾体苯基噻吩化合物，其高钙血症性低于 1α，25 二羟基维生素 D3。这些化合物可用于治疗骨病和牛皮癣。
• Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives
  作者：Hitoshi Sasaki、Yoshiyuki Mori、Junzo Nakamura、Juichiro Shibasaki

  DOI：10.1021/jm00106a025

  日期：1991.2

  Several 1-acyl-2-pyrrolidinone derivatives were synthesized as derivatives of gamma-aminobutyric acid (GABA), and their pharmacological activities and stabilities were investigated. The derivatives showed anticonvulsant effect on picrotoxin-induced seizure at a dose of 200 mg/kg. In particular, 1-decanoyl-2-pyrrolidinone (7) and 1-dodecanoyl-2-pyrrolidinone (8) had a high activity. The anticonvulsant activity showed a dose dependency. Some of 1-acyl-2-pyrrolidinone derivatives prolonged sleeping time which was induced by sodium pentobarbital and showed a recovery from disruption of the memory of passive avoidance response, which was induced by an electroconvulsive shock. As shown by the results of the stability study of 1-acetyl-2-pyrrolidinone (1), it was degraded in an acidic buffer and an alkaline buffer although 2-pyrrolidinone was stable. 1-Acyl-2-pyrrolidinone derivatives were degraded in liver and brain homogenates of mouse and rat. They showed a degradation rate in rat plasma. Conversion of 8 to GABA in mouse liver homogenate was demonstrated. These results suggested that the pharmacological activity of 1-acyl-2-pyrrolidinone is probably due to the release of GABA by hydrolysis of derivatives although further work is necessary.