5,7-dimethylquinazolin-4-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5,7-dimethylquinazolin-4-ol
• 英文别名: 5,7-dimethyl-3H-quinazolin-4-one
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: NDZGYZXQDNRSSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,7-dimethylquinazolin-4-ol 在 氢溴酸 、 sodium methylate 作用下， 生成 3-[3-(3-hydroxy-[2]piperidyl)-2-oxo-propyl]-5,7-dimethyl-3H-quinazolin-4-one
  参考文献：
  名称：

  AN ANTIMALARIAL ALKALOID FROM HYDRANGEA. XV. SYNTHESIS OF 5-, 6-, 7-, AND 8-DERIVATIVES WITH TWO IDENTICAL SUBSTITUENTS

  摘要：

  DOI：

  10.1021/jo01135a015
• 作为产物：
  描述：

  2,4-二甲基-6-硝基苯甲腈 在 palladium on activated charcoal 、 乙二醇甲醚 、 硫酸 作用下， 生成 5,7-dimethylquinazolin-4-ol
  参考文献：
  名称：

  AN ANTIMALARIAL ALKALOID FROM HYDRANGEA. XV. SYNTHESIS OF 5-, 6-, 7-, AND 8-DERIVATIVES WITH TWO IDENTICAL SUBSTITUENTS

  摘要：

  DOI：

  10.1021/jo01135a015

文献信息

• [EN] PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)<br/>[FR] DÉRIVÉS DE PYRAZOLO[1,5-A]PYRIMIDINE SUBSTITUÉS PAR PIPÉRIDIN, AYANT UNE ACTIVITÉ INHIBITRICE SUR LA RÉPLICATION DU VIRUS RESPIRATOIRE SYNCYTIAL (RSV)
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：WO2016091774A1

  公开（公告）日：2016-06-16

  The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

  这项发明涉及具有抗病毒活性的新型取代的双环吡唑嘧啶化合物，特别是对呼吸道合胞病毒（RSV）复制具有抑制活性的化合物。该发明还涉及制备这种新型化合物，包含这些化合物的组合物，以及用于治疗呼吸道合胞病毒感染的化合物。
• COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES
  申请人：Hansen Henrik C.

  公开号：US20120015905A1

  公开（公告）日：2012-01-19

  The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.

  本公开涉及化合物，这些化合物有助于调节载脂蛋白A-I（ApoA-I）的表达，并可用于治疗和预防心血管疾病及相关疾病状态，包括胆固醇或脂质相关疾病，例如动脉粥样硬化。
• 4(3H)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds
  申请人：Ishikawa, Masayuki

  公开号：EP0056637A1

  公开（公告）日：1982-07-28

  4(3H)-quinazolinones of formula wherein R1 and R3, independently from each other, represent a lower alkyl group; R2 represents a lower alkoxycarbonyl group; Q represents a phenyl group or a substituted phenyl group R4 represents a hydrogen atom or a lower alkyl group; R5 represents a member selected from the group consisting of a hydrogen atom, lower alkyl groups, lower halogenoalkyl groups, lower alkenyl groups, (lower)alkoxy-(lower)alkyl groups, hydroxy(lower)alkyl groups, (lower) alkylthio(lower)alkyl groups, (lower)alkylsulfinyl(lower) alkyl groups, (lower)alkylsulfonyl(lower)alkyl groups, di(lower)-alkylamino(lower)alkyl groups, a benzyl group, a phenethyl group, pyridyl(lower)alkyl groups, furfuryl groups, a phenyl group, and substituted phenyl groups. Z, and Z2, independently from each other, represent an oxygen or sulfur atom; and an acid addition salts thereof, are useful as hypotensive agents. There is also disclosed a process for the production of these derivatives and pharmaceutical compositions comprising said compounds.

  式中的 4(3H)-喹唑啉酮 式中 R1 和 R3 各自代表一个低级烷基 R2 代表低级烷氧基羰基 Q 代表苯基或取代苯基 R4 代表氢原子或低级烷基 R5 代表选自由氢原子、低级烷基、低级卤代烷基、低级烯基、(低级)烷氧基-(低级)烷基、羟基(低级)烷基、(低级)烷硫基(低级)烷基组成的组、(低级)烷基亚磺酰(低级)烷基、(低级)烷基磺酰基、二(低级)烷基氨基(低级)烷基、苄基、苯乙基、吡啶基(低级)烷基、糠基、苯基和取代苯基。 Z和Z2相互独立地代表氧原子或硫原子；其酸加成盐可用作降血压剂。还公开了一种生产这些衍生物和包含上述化合物的药物组合物的工艺。
• PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)
  申请人：Janssen Sciences Ireland UC

  公开号：EP3230287B1

  公开（公告）日：2018-10-10
• SUBSTITUTED QUINAZOLINE COMPOUNDS AND PREPARATION AND USES THEREOF
  申请人：Sunshine Lake Pharma Co., Ltd.

  公开号：US20180215737A1

  公开（公告）日：2018-08-02

  The present invention relates quinazolinone compounds of Formula (I), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses; wherein the compounds or pharmaceutical compositions disclosed herein can be used for antagonizing the orexin receptor. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing neurological and psychiatric disorders and diseases of the central nervous system in mammals, especially in humans.