1-(3-butyl-3-butenyl)benzene | 115045-60-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-butyl-3-butenyl)benzene
• 英文别名: 2-(2-phenylethyl)-1-hexene；3-Methylideneheptylbenzene
• CAS: 115045-60-8
• 化学式: C₁₄H₂₀
• 分子量: 188.313
• InChiKey: YPLGJTYAYCWEMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  正丁基硼酸 、 (3-bromobut-3-en-1-yl)benzene 在 dicyclohexyl(2,4,6-trimethoxyphenyl)phosphonium tetrafluoroborate 、 palladium diacetate 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 5.5h， 以8%的产率得到1-(3-butyl-3-butenyl)benzene
  参考文献：
  名称：

  LB-Phos·HBF4在2-Bromoalken-3-ols与烷基硼酸Suzuki偶联反应中的应用

  摘要：

  LB-Phos·HBF4用于2-bromoalken-3-ols与烷基硼酸的Suzuki偶联反应，以中等至良好的产率得到偶联产物。取代基如苄基、苯基、烯丙基和烷基在 2-溴链烯-3-醇的 1-和 3-位是可耐受的。伯烷基硼酸和仲烷基硼酸的反应均顺利进行。

  DOI：

  10.1002/ejoc.201200350

文献信息

• Synthesis of 1,1-Disubstituted Ethenes by Means of Sequential Cross-Coupling Reactions
  作者：V. Fiandanese、G. Marchese、F. Naso、L. Ronzini

  DOI：10.1055/s-1987-28164

  日期：——

  A variety of 1-alkenes are synthesized in 63-91% yields by means of sequential cross-coupling reactions of Grignard reagents with readily available or commercial starting materials, in the presence of transition-metal catalysts.

  通过过渡金属催化剂的存在下，一系列的1-烯烃以63-91%的产率被合成，这是通过易于获得的或商品化的起始材料与格氏试剂的连续交叉偶联反应实现的。
• Direct preparation of substituted olefins from epoxides utilizing lithium tetraalkylcerate
  作者：Yutaka Ukaji、Tamotsu Fujisawa

  DOI：10.1016/s0040-4039(00)80709-1

  日期：1988.1

  Alkylated olefins were directly synthesized in good yields by the deoxygenation reaction of epoxides with concomitant introduction of the alkyl group using lithium tetraalkylcerate. Styreneoxide and (1-naphthyl)ethyleneoxide gave terminal olefins, while ethyleneoxide replaced by aliphatic substituent, 1,2-epoxy-4-phenyl butane, afforded internal olefin. The utility of the present method was demonstrated

  通过环氧化物的脱氧反应并同时使用四烷基铈酸锂引入烷基，可以高收率直接合成烷基化烯烃。苯乙烯氧化物和（1-萘基）环氧乙烷产生末端烯烃，而环氧乙烷被脂肪族取代基1,2-环氧-4-苯基丁烷代替，得到内烯烃。本方法的实用性在倍半萜烯，脱氢-α-姜黄素的一步合成中得到了证明。
• New Carbonyl Olefination Using Thioacetals
  作者：Yasuo Horikawa、Mikako Watanabe、Tooru Fujiwara、Takeshi Takeda

  DOI：10.1021/ja962240d

  日期：1997.2.1
• Selective mono- and polymethylene homologations of copper reagents using (iodomethyl)zinc iodide
  作者：AchyuthaRao Sidduri、Michael J. Rozema、Paul Knochel

  DOI：10.1021/jo00062a010

  日期：1993.5

  A wide range of unsaturated aryl-, alkenyl-, alkynylcopper compounds can be selectively homologated by a methylene unit using (iodomethyl)zinc iodide or bis(iodomethyl)zinc. These reactions allow the generation of mixed allylic zinc-copper compounds which can be efficiently trapped with carbonyl compounds. An application to a general preparation of functionalized alpha-methylene-gamma-butyrolactones is described. The homologation of alkynylcoppers with (iodomethyl)zinc iodide allows a one-pot preparation of propargylic copper reagents which in the presence of a carbonyl compound provide various homopropargylic alcohols in excellent yields. In the absence of an electrophile, a clean quadruple methylene homologation of alkynylcoppers occurs to furnish dienic copper reagents. The homologation of other types of copper reagents is also possible, and carbanions at the alpha-position to amines as well as homoenolates of aldehydes or ketones can also be prepared by this method.
• FIANDANESE, V.;MARCHESE, G.;NASO, F.;RONZINI, L., SYNTHESIS,(1987) N 11, 1034-1036
  作者：FIANDANESE, V.、MARCHESE, G.、NASO, F.、RONZINI, L.

  DOI：——

  日期：——