3-hydroxy-5-[3-(tert-butyldimethylsilyloxy)propyloxy]benzyl alcohol | 324077-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-hydroxy-5-[3-(tert-butyldimethylsilyloxy)propyloxy]benzyl alcohol
• CAS: 324077-14-7
• 化学式: C₁₆H₂₈O₄Si
• 分子量: 312.481
• InChiKey: ZEPJHNAIUVKBRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  21.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3-hydroxy-5-[3-(tert-butyldimethylsilyloxy)propyloxy]benzyl alcohol 在 18-冠醚-6 、 potassium carbonate 、 三乙胺 、 lithium bromide 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 74.0h， 生成 3-(3-phenoxy)propyloxy-5-[3-(tert-butyldimethylsilyloxy)propyloxy]-benzyl bromide
  参考文献：
  名称：

  Dendrimeric Organochalcogen Catalysts for the Activation of Hydrogen Peroxide:  Improved Catalytic Activity through Statistical Effects and Cooperativity in Successive Generations

  摘要：

  Dendrimeric polyphenylsulfides, -selenides, and -tellurides are prepared in high yield using propyloxy spacers to connect the phenylchalcogeno groups to the dendrimeric core. The selenides and tellurides catalyze the oxidation of bromide with hydrogen peroxide to give positive bromine species that can be captured by cyclohexene in two-phase systems. The corresponding sulfides show no catalytic activity. The increase in the rate of catalysis followed statistical effects for 1, 6, and 12 phenyltelluro groups. However, the increase in the rate of catalysis exceeds statistical contributions for the first few generations with 1, 3, 6, and 12 phenylseleno groups and suggested cooperativity among phenylseleno groups. The increase in catalytic rate was lost upon replacing all but one phenylseleno group with phenoxy groups. On the basis of H2O2 consumed, the dendrimer with 12 phenylseleno groups has a turnover number of >60 000 mol of H2O2 consumed per mole of catalyst.

  DOI：

  10.1021/ja002649+
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 4-二甲氨基吡啶 、 18-冠醚-6 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 66.0h， 生成 3-hydroxy-5-[3-(tert-butyldimethylsilyloxy)propyloxy]benzyl alcohol
  参考文献：
  名称：

  Dendrimeric Organochalcogen Catalysts for the Activation of Hydrogen Peroxide:  Improved Catalytic Activity through Statistical Effects and Cooperativity in Successive Generations

  摘要：

  Dendrimeric polyphenylsulfides, -selenides, and -tellurides are prepared in high yield using propyloxy spacers to connect the phenylchalcogeno groups to the dendrimeric core. The selenides and tellurides catalyze the oxidation of bromide with hydrogen peroxide to give positive bromine species that can be captured by cyclohexene in two-phase systems. The corresponding sulfides show no catalytic activity. The increase in the rate of catalysis followed statistical effects for 1, 6, and 12 phenyltelluro groups. However, the increase in the rate of catalysis exceeds statistical contributions for the first few generations with 1, 3, 6, and 12 phenylseleno groups and suggested cooperativity among phenylseleno groups. The increase in catalytic rate was lost upon replacing all but one phenylseleno group with phenoxy groups. On the basis of H2O2 consumed, the dendrimer with 12 phenylseleno groups has a turnover number of >60 000 mol of H2O2 consumed per mole of catalyst.

  DOI：

  10.1021/ja002649+