5,6,7-三甲基-1,8-萘啶-2-胺 | 69587-84-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 5,6,7-三甲基-1,8-萘啶-2-胺
• 中文别名: 2-氨基-5,6,7-三甲基-1,8-萘啶
• 英文名称: 2-amino-5,6,7-trimethyl-1,8-naphthyridine
• 英文别名: ATMND；5,6,7-trimethyl-[1,8]naphthyridin-2-ylamine；5,6,7-trimethyl-1,8-naphthyridin-2-amine
• CAS: 69587-84-4
• 化学式: C₁₁H₁₃N₃
• mdl: MFCD08262809
• 分子量: 187.244
• InChiKey: ZZZNDZVOGHOUET-UHFFFAOYSA-N

物化性质

• 熔点：
  >230℃
• 溶解度：
  甲醇（少量溶解）、水（少量，加热）

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5,6,7-三甲基-1,8-萘啶-2-胺 在 硫酸 、 sodium nitrite 、 三氯氧磷 作用下， 反应 12.0h， 生成 2-chloro-5,6,7-trimethyl-1,8-naphthyridine
  参考文献：
  名称：

  小分子，环境敏感染料偶联物的比率荧光信号，可检测DNA中的单碱基突变

  摘要：

  绑定！基于DNA结合配体与对环境敏感的染料缀合以探测DNA螺旋的疏水沟的比例荧光探针被开发出来。产生的共轭物ATMND–DBD可以与对无碱基（AP）位点相对的孤核碱基结合，对嘧啶碱基具有很高的选择性和亲和力（见图）。

  DOI：

  10.1002/chem.201200219
• 作为产物：
  描述：

  2,6-二氨基吡啶 、 3-甲基-2,4-戊烷二酮 在 磷酸 作用下， 反应 13.0h， 以48%的产率得到5,6,7-三甲基-1,8-萘啶-2-胺
  参考文献：
  名称：

  小分子，环境敏感染料偶联物的比率荧光信号，可检测DNA中的单碱基突变

  摘要：

  绑定！基于DNA结合配体与对环境敏感的染料缀合以探测DNA螺旋的疏水沟的比例荧光探针被开发出来。产生的共轭物ATMND–DBD可以与对无碱基（AP）位点相对的孤核碱基结合，对嘧啶碱基具有很高的选择性和亲和力（见图）。

  DOI：

  10.1002/chem.201200219

文献信息

• Substituted naphthyridinones, processes for their preparations and therapeutical applications
  申请人：Merck & Co., Inc.

  公开号：EP0000490A1

  公开（公告）日：1979-02-07

  Compounds of formula wherein X is sulfur, oxygen or imino; n is an integer of from 2 to 6 such that the length of the carbon chain connecting the two nitrogen atoms is not less than 2; R1,R2,R3,R4 and R5 are independently hydrogen, loweralkyl, loweralkoxy, amino, haloloweralkyl, or phenyl; or any two adjacent substituents may be joined to form a benzo substituent; R6 and R7 are independently hydrogen, phenyl-loweralkyl, N-Loweralkylcarbamoyl N-loweralkylthiocarbamoyl; or R6 and R, may be joined to form a morpholino ring or R6 and R7 may be an alkylene linkage of 4 or 5 carbon atoms to form a pyrrolidine or piperidine group which may be substituted with loweralkyl, oxo or benzo substituents; and the broken line in the 3,4 position of the naphthyridine molecule indicates that the bond may be either a single or a double bond; and the acid addition and quaternary ammonium salts thereof, provided that when n is 2, R3, R5, R6, and R7 are all methyl groups, X is oxygen and the 3,4-position is unsaturated at least one of R1, R2 or R4 is other than hydrogen are disclosed. These compounds inhibit gastric secretions in the gastro-intestinal tract.

  式的化合物 式中 X 是硫、氧或亚氨基； n 是 2 到 6 的整数，连接两个氮原子的碳链长度不小于 2； R1、R2、R3、R4 和 R5 独立地是氢、低级烷基、低级烷氧基、氨基、卤代低级烷基或苯基；或任意两个相邻取代基可连接形成苯并取代基； R6 和 R7 独立地为氢、苯基-低级烷基、N-低级烷基氨基甲酰基 N-低级烷基硫代氨基甲酰基；或 R6 和 R，可连接形成吗啉环，或 R6 和 R7 可为 4 或 5 个碳原子的亚烷基连接，形成可被低级烷基、氧代或苯并取代基取代的吡咯烷或哌啶基；萘啶分子 3,4 位上的断线表示该键可以是单键或双键；公开了其酸加成盐和季铵盐，条件是当 n 为 2，R3、R5、R6 和 R7 均为甲基，X 为氧，且 3,4 位为不饱和位时，R1、R2 或 R4 中至少有一个不是氢。 这些化合物可抑制胃肠道的胃液分泌。
• Materials and methods for rapid and sensitive detection of small-molecule targets
  申请人：Xiao Yi

  公开号：US10550395B2

  公开（公告）日：2020-02-04

  The subject invention provides methods, assays and products for detecting small-molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target in a sample comprises providing a sample, contacting the sample with an aptamer-based sensor selective for the small-molecule target, and sensitively and rapidly detecting the small-molecule target in the sample. Specifically, the method utilizes EATR-amplified small-molecule sensors based on cooperative binding split aptamers (CBSAs).

  本发明提供了特别是在临床和现场环境中检测样品中的小分子的方法、检测方法和产品。检测样品中的小分子目标物的方法包括提供样品，将样品与对小分子目标物有选择性的基于适配体的传感器接触，灵敏而快速地检测样品中的小分子目标物。具体地说，该方法利用了基于合作结合分裂拟合物（CBSA）的 EATR 扩增小分子传感器。
• Methods for generating structure-switching aptamers and uses thereof
  申请人：Xiao Yi

  公开号：US11162960B2

  公开（公告）日：2021-11-02

  The subject invention provides methods, assays, and products for detecting small-molecule targets in a complex sample in both clinical and field settings. The subject invention provides aptamer-based sensors and methods of use thereof. The subject invention provides exonuclease-based methods for generating structure-switching aptamers from fully folded or pre-folded aptamers and developing aptamer-based sensors for small-molecule detection. The method for detecting one or more small-molecule targets in a sample comprises contacting the sample with one or more aptamer-based sensor selective for each of the small-molecule targets, and detecting the small-molecule target in the sample.

  本发明提供了在临床和现场环境中检测复杂样本中的小分子靶标的方法、检测方法和产品。本发明提供了基于适配体的传感器及其使用方法。本发明提供了基于外切核酸酶的方法，用于从完全折叠或预折叠的适配体生成结构转换适配体，并开发基于适配体的小分子检测传感器。检测样品中一种或多种小分子靶标的方法包括将样品与一种或多种对每种小分子靶标具有选择性的基于适配体的传感器接触，并检测样品中的小分子靶标。
• APTAMERS FOR TOPICAL DELIVERY
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：EP3119435A1

  公开（公告）日：2017-01-25
• LABEL-FREE FUNCTIONAL NUCLEIC ACID SENSORS FOR DETECTING TARGET AGENTS
  申请人：Lu Yi

  公开号：US20120252128A1

  公开（公告）日：2012-10-04

  A general methodology to design label-free fluorescent functional nucleic acid sensors using a vacant site approach and an abasic site approach is described. In one example, a method for designing label-free fluorescent functional nucleic acid sensors (e.g., those that include a DNAzyme, aptamer or aptazyme) that have a tunable dynamic range through the introduction of an abasic site (e.g., dSpacer) or a vacant site into the functional nucleic acids. Also provided is a general method for designing label-free fluorescent aptamer sensors based on the regulation of malachite green (MG) fluorescence. A general method for designing label-free fluorescent catalytic and molecular beacons (CAMBs) is also provided. The methods demonstrated here can be used to design many other label-free fluorescent sensors to detect a wide range of analytes. Sensors and methods of using the disclosed sensors are also provided.