JNMS-38 | 1027037-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: JNMS-38
• 英文别名: 4-(4-(Thiiran-2-ylmethylsulfonyl)phenoxy)phenyl methanesulfonate；[4-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenyl] methanesulfonate
• CAS: 1027037-37-1
• 化学式: C₁₆H₁₆O₆S₃
• 分子量: 400.497
• InChiKey: IEHSRERHOYOHOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  129
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-[4-(Thiiran-2-ylmethylsulfonyl)phenoxy]phenol 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以84%的产率得到JNMS-38
  参考文献：
  名称：

  Sulfonate-Containing Thiiranes as Selective Gelatinase Inhibitors

  摘要：

  Matrix metalloproteinases (MMPs) are important zinc-dependent endopeptidases. Two members of this family of enzymes called gelatinases (MMP-2 and MMP-9) have been implicated in a number of human diseases, including cancer, neurological and cardiovascular diseases, and inflammation to name a few. We describe in this report the preparation and evaluation of two structural types of thiirane inhibitors that show selectivity toward gelatinases. The biphenyl series targets both gelatinases, whereas the monophenyl analogues exhibit potent inhibition of only MMP-2. The latter structural type also exhibits improved water solubility and metabolic stability, both traits desirable for progress of these molecules forward in gelatinase-dependent animal models of disease.

  DOI：

  10.1021/ml100254e

文献信息

• [EN] ACCELERATION OF DIABETIC WOUND HEALING<br/>[FR] ACCÉLÉRATION DE LA CICATRISATION DES PLAIES DIABÉTIQUES
  申请人：UNIV NOTRE DAME DU LAC

  公开号：WO2016044844A1

  公开（公告）日：2016-03-24

  The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with the enzyme MMP-8, or the topical treatment of the wound with MMP-8 in combination with administration of an MMP-9 inhibitor, to accelerate the healing of the wound.

  本发明提供了化合物、组成物和方法，以改善或加速伤口的愈合。在各种实施例中，该方法可以包括使用酶MMP-8局部治疗伤口，或者使用MMP-8与MMP-9抑制剂的联合局部治疗伤口，以加速伤口的愈合。
• Inhibitors of Matrix Metallaproteinases
  申请人：Lee Mijoon

  公开号：US20090005420A1

  公开（公告）日：2009-01-01

  The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.

  本发明提供了式I-IX的新化合物，如本文所述。还提供了式I-IX化合物的组合物，制备式I-IX化合物的方法以及使用式I-IX化合物的方法。本发明中的化合物可用于抑制基质金属蛋白酶，并可用于治疗与之相关的疾病和症状。
• INHIBITORS OF MATRIX METALLOPROTEINASES
  申请人：Lee Mijoon

  公开号：US20110224275A1

  公开（公告）日：2011-09-15

  The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.

  本发明提供了如公式I-IX所述的新化合物。还提供了公式I-IX化合物的组合物、制备公式I-IX化合物的方法以及使用公式I-IX化合物的方法。本发明的化合物可用于抑制基质金属蛋白酶，并可用于治疗与之相关的疾病和病症。
• Acceleration of diabetic wound healing
  申请人：University of Notre Dame du Lac

  公开号：US10357546B2

  公开（公告）日：2019-07-23

  The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with the enzyme MMP-8, or the topical treatment of the wound with MMP-8 in combination with administration of an MMP-9 inhibitor, to accelerate the healing of the wound.

  本发明提供了改善或加速伤口愈合的化合物、组合物和方法。在各种实施方案中，这些方法可包括用 MMP-8 酶局部治疗伤口，或用 MMP-8 结合 MMP-9 抑制剂局部治疗伤口，以加速伤口愈合。
• WO2006/125208
  申请人：——

  公开号：——

  公开（公告）日：——