(2'R,4'S)-2',4'-dichloro-2'l5,4l5,4'l5-spiro[dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine-4,6'-2,5,8,11,14-pentaoxa-1(2,4)-triazatriphosphininacyclotetradecaphane] | 1285527-91-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2'R,4'S)-2',4'-dichloro-2'l5,4l5,4'l5-spiro[dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine-4,6'-2,5,8,11,14-pentaoxa-1(2,4)-triazatriphosphininacyclotetradecaphane]
• CAS: 1285527-91-4
• 化学式: C₂₈H₂₈Cl₂N₃O₇P₃
• 分子量: 682.374
• InChiKey: GXCTXNICRPVKAF-ZRKBJOGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.86
• 重原子数：
  43.0
• 可旋转键数：
  0.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  101.69
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  (2'R,4'S)-2',4'-dichloro-2'l5,4l5,4'l5-spiro[dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine-4,6'-2,5,8,11,14-pentaoxa-1(2,4)-triazatriphosphininacyclotetradecaphane] 、 N-tosyl L-tyrosine methyl ester 在 sodium carbonate 作用下， 以 乙腈 为溶剂， 反应 96.0h， 以88%的产率得到methyl (2S)-3-[4-(15'-chlorospiro[12,14-dioxa-13-phosphoniapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene-13,17'-2,5,8,11,14-pentaoxa-18-aza-16,19-diazanida-1lambda5-phospha-15,17-diphosphoniabicyclo[13.3.1]nonadec-1(18)-ene]-1'-yl)oxyphenyl]-2-[(4-methylphenyl)sulfonylamino]propanoate
  参考文献：
  名称：

  Selective O-functionalization of phenolic α-amino acids with crown ethers bearing cyclophosphazene sub-units

  摘要：

  Cyclophosphazenes (CyP) containing a crown ether and an alpha-amino acid unit have been prepared starting from diphosphaza[16]crown-6 (PNP16C6). Nucleophilic substitution of one (or both) residual ansa-chlorine atom(s) of bis-spiro substituted PNP16C6 by alpha-arylsulfonamido esters containing a phenolic function leads to the target compounds. These new polyfunctionalized CyP are lariat ethers, potentially useful as starting materials for the preparation of 'pH-controlled active ion carriers' in liquid membranes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.053
• 作为产物：
  描述：

  三缩四乙二醇 在 六氯环三磷腈 、 sodium hydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙腈 、 mineral oil 为溶剂， 反应 24.0h， 生成 (2'R,4'S)-2',4'-dichloro-2'l5,4l5,4'l5-spiro[dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine-4,6'-2,5,8,11,14-pentaoxa-1(2,4)-triazatriphosphininacyclotetradecaphane]
  参考文献：
  名称：

  Selective O-functionalization of phenolic α-amino acids with crown ethers bearing cyclophosphazene sub-units

  摘要：

  Cyclophosphazenes (CyP) containing a crown ether and an alpha-amino acid unit have been prepared starting from diphosphaza[16]crown-6 (PNP16C6). Nucleophilic substitution of one (or both) residual ansa-chlorine atom(s) of bis-spiro substituted PNP16C6 by alpha-arylsulfonamido esters containing a phenolic function leads to the target compounds. These new polyfunctionalized CyP are lariat ethers, potentially useful as starting materials for the preparation of 'pH-controlled active ion carriers' in liquid membranes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.053