3-(tert-butyl)cyclopentanamine | 61888-95-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(tert-butyl)cyclopentanamine
• 英文别名: 3-tert-Butylcyclopentan-1-amine
• CAS: 61888-95-7
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: FTNCLUXXFWNCTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Carbamic acid,[[4-[2-[(2-methoxy-5-methylbenzoyl)amino]ethyl]phenyl]sulfonyl]-, methylester 、 3-(tert-butyl)cyclopentanamine 生成 Benzamide,N-[2-[4-[[[[[3-(1,1-dimethylethyl)cyclopentyl]amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-5-methyl-
  参考文献：
  名称：

  DE1793072

  摘要：

  公开号：
• 作为产物：
  描述：

  3-(叔丁基)环戊酮 在 palladium on activated charcoal 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 52.5h， 生成 3-(tert-butyl)cyclopentanamine
  参考文献：
  名称：

  Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

  摘要：

  Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against T. cruzi. The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series.

  DOI：

  10.1021/acs.jmedchem.9b01852

文献信息

• [EN] TREATMENT OF CHAGAS DISEASE<br/>[FR] TRAITEMENT DE LA MALADIE DE CHAGAS
  申请人：UNIV DUNDEE

  公开号：WO2015189595A1

  公开（公告）日：2015-12-17

  The invention provides compounds of the formula: wherein L1 and L2 are independently selected from O and S; R1 is C3-C6straight or branched alkyl, C3-C7cycloalkyl, C5-C7cycloalkenyl, adamantly, phenyl or saturated heterocyclyl, any of which being optionally substituted; R2 is H, methyl or ethyl; R5 is NRxCORy, NRxRy, CH2COCH3, CH2C≡N, or a 5- or 6-membered heteroaryl group which is optionally substituted; X, Y and Z are independently N or CH; Rx is independently H or C1-C4alkyl; Ry is independently H, CrC4alkyl, phenyl or benzyl, either of which is optionally substituted; n is 0-3; salts, hydrates and N-oxides, wherein the optional substituents are further defined in the claims. The compounds have utility in the prophylaxis or treatment of trypanosomal diseases, such as T. cruzi (Chagas disease).

  该发明提供了以下式的化合物：其中L1和L2分别选自O和S；R1为C3-C6直链或支链烷基，C3-C7环烷基，C5-C7环烯基，脱氢胆固醇，苯基或饱和杂环烷基，其中任一可选择地被取代；R2为H，甲基或乙基；R5为NRxCORy，NRxRy，CH2COCH3，CH2C≡N，或者是可选择地被取代的5-或6-成员杂芳基团；X、Y和Z分别为N或CH；Rx分别为H或C1-C4烷基；Ry分别为H，CrC4烷基，苯基或苄基，其中任一可选择地被取代；n为0-3；盐、水合物和N-氧化物，其中可选择的取代基在权利要求中进一步定义。这些化合物在预防或治疗锥虫病等锥虫病方面具有用途。
• Carbacyclin analogues
  申请人：THE UPJOHN COMPANY

  公开号：EP0159784A1

  公开（公告）日：1985-10-30

  A compound of the formula and intermediates useful in preparing same.

  一种化合物的公式及其制备过程中有用的中间体。
• Sulfonamide Compounds and Uses Thereof
  申请人：Saunders O. Jeffrey

  公开号：US20070270473A1

  公开（公告）日：2007-11-22

  Compounds that modulate GHS-R are described, for examples compounds formula (I)

  描述了调节GHS-R的化合物，例如化合物公式（I）。
• SULFONAMIDE COMPOUNDS AND USES THEREOF
  申请人：Saunders Jeffrey O.

  公开号：US20110152232A1

  公开（公告）日：2011-06-23

  Compounds that modulate GHS-R are described, for examples compounds formula (I)

  调节GHS-R的化合物已被描述，例如化合物公式(I)。
• 9-Substituted carbacyclin analogues
  申请人：THE UPJOHN COMPANY

  公开号：EP0086611A1

  公开（公告）日：1983-08-24

  Novel compounds of the following general formula: wherein R is -CN; -CH2X wherein X is chloro or bromo; -CH=CH2; -CHO; -CH20H; -C≡CH; -C≡C-CF3; -C≡C-CnH2nCH3 wherein n is zero, one, 2 or 3; cis-CH=CHCnH2nCH3 or trans -CH=CHCnH2nCH3 wherein n is zero, one, 2 or 3; -CH=C(X')2 wherein X' is fluoro, chloro, or bromo; cis-CH=CHX' or trans-CH=CHX' wherein X' is fluoro, chloro, or bromo;-C≡C-C≡CR1 wherein R1 is hydrogen, methyl, or ethyl; -C≡COR2 wherein R2 is methyl or ethyl; and intermediates for their preparation.

  以下通式的新型化合物： 其中 R 是 -CN；- X，其中 X 是氯或溴；-CH=CH2；-CHO；- 0H；-C≡CH；-C≡C-CF3；-C≡C-CnH2nCH3，其中 n 是零、1、2 或 3；顺式-CH=CHCnH2nCH3 或反式-CH=CHCnH2nCH3，其中 n 是零、1、2 或 3；顺式-CH=C(X')2，其中 X'为氟、氯或溴；顺式-CH=CHX'或反式-CH=CHX'，其中 X'为氟、氯或溴；-C≡C-C≡CR1，其中 R1 为氢、甲基或乙基；-C≡COR2，其中 R2 为甲基或乙基；以及用于制备它们的中间体。