benzyl-(1,1,3,3-tetramethyl-butyl)-amine | 3598-75-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl-(1,1,3,3-tetramethyl-butyl)-amine
• 英文别名: N-benzyl-2,4,4-trimethylpentan-2-amine；Benzyl-(1,1,3,3-tetramethyl-butyl)-amin；2-Benzylamino-2,4,4-trimethyl-pentan
• CAS: 3598-75-2
• 化学式: C₁₅H₂₅N
• mdl: MFCD07410701
• 分子量: 219.37
• InChiKey: SRNCZQHDQZRJHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  环氧乙烷 、 benzyl-(1,1,3,3-tetramethyl-butyl)-amine 生成 2-[benzyl-(1,1,3,3-tetramethyl-butyl)-amino]-ethanol
  参考文献：
  名称：

  Local Anesthetics. VII. Monoalkylamino-4-alkoxy-3-aminobenzoates and 3-Alkoxy-4-aminobenzoates¹

  摘要：

  DOI：

  10.1021/ja01549a051
• 作为产物：
  描述：

  叔辛胺 在 镍 作用下， 生成 benzyl-(1,1,3,3-tetramethyl-butyl)-amine
  参考文献：
  名称：

  Local Anesthetics. VII. Monoalkylamino-4-alkoxy-3-aminobenzoates and 3-Alkoxy-4-aminobenzoates¹

  摘要：

  DOI：

  10.1021/ja01549a051

文献信息

• Cesium Effect:  High Chemoselectivity in Direct N-Alkylation of Amines
  作者：Ralph Nicholas Salvatore、Advait S. Nagle、Kyung Woon Jung

  DOI：10.1021/jo010643c

  日期：2002.2.1

  A novel method for the mono-N-alkylation of primary amines, diamines, and polyamines was developed using cesium bases in order to prepare secondary amines efficiently. A cesium base not only promoted alkylation of primary amines but also suppressed overalkylations of the produced secondary amines. Various amines, alkyl bromides, and alkyl sulfonates were examined, and the results demonstrated this

  为了有效地制备仲胺，使用铯碱开发了一种用于伯胺，二胺和多胺的单N-烷基化的新方法。铯碱不仅促进伯胺的烷基化，而且抑制产生的仲胺的过度烷基化。检查了各种胺，烷基溴化物和烷基磺酸盐，结果表明该方法具有较高的化学选择性，比单烷基化更有利于单-N-烷基化。特别地，使用空间要求高的底物或氨基酸衍生物可专门提供仲胺，在拟肽合成中具有广泛的应用。
• Reductive amination using ammonia borane
  作者：P. Veeraraghavan Ramachandran、Pravin D. Gagare、Kaumba Sakavuyi、Paul Clark

  DOI：10.1016/j.tetlet.2010.04.014

  日期：2010.6

  A variety of primary, secondary, and tertiary amines were prepared in 84–95% yields using ammonia borane for the reductive amination of aldehydes and ketones in the presence of titanium isopropoxide.

  在异丙醇钛存在下，使用氨硼烷对醛和酮进行还原胺化反应，制得了各种伯胺，仲胺和叔胺，产率为84–95％。
• Ruthenium-Catalyzed Synthesis of Secondary Alkylamines: Selective Alkylation with Aliphatic Amines
  作者：Sebastian Bähn、Dirk Hollmann、Annegret Tillack、Matthias Beller

  DOI：10.1002/adsc.200800353

  日期：2008.9.5

  N-alkylation of tert-alkylamines applying aliphatic amines is described for the first time. In the presence of the Shvo catalyst 1, tert-octylamine 4 and 1-adamantylamine 5 are alkylated using primary, secondary, and even tertiary amines to give the corresponding monoalkylated tert-alkylamine in moderate to very good yields and excellent selectivity. This novel reaction proceeds without an additional

  首次描述了应用脂肪族胺的叔烷基胺的化学选择性N-烷基化。在Shvo催化剂的存在下1，叔-octylamine 4和1-金刚烷基胺5使用伯，仲，和甚至叔胺，得到烷基化的单烷基化对应的叔烷基胺在中度至非常好的产率和良好的选择性。这种新颖的反应无需额外的氢源即可进行，并且氨是唯一的副产物。
• Organic thiosulphates and thiosulphonates useful as stabilising agents for rubber vulcanisates
  申请人：MONSANTO EUROPE S.A.

  公开号：EP0070143A1

  公开（公告）日：1983-01-19

  Additives for rubber compositions, giving vulcanisates having improved retention of optimum physical properties, are compounds containing two or more groups of the formula -S-S02R linked by an organic bridging group, or polymers containing two or more groups of the formula -S-S02R attached to an organic polymer chain, where R represents (a) a radical OM where M is a monovalent metal, the equivalent of a multivalent metal, a monovalent ion derived by the addition of a proton to a nitrogenous base, or the equivalent of a multivalent ion derived by the addition of two or more protons to a nitrogenous base, or (b) an organic radical selected from aliphatic, cycloaliphatic, aromatic and heterocyclic radicals, and radicals which are combinations of any two or more such radicals.

  用于橡胶组合物的添加剂，使硫化胶能更好地保持最佳物理性能，这些添加剂是含有两个或两个以上由有机桥基连接的式-S-S02R 的化合物，或含有两个或两个以上连接到有机聚合物链上的式-S-S02R 的聚合物，其中 R 代表 (a) 自由基 OM，其中 M 是一价金属、(b) 选自脂肪族、环脂族、芳香族和杂环族的有机自由基，以及由任意两个或多个此类 自由基组合而成的自由基。
• Vulcanisable rubber composition and compounds useful as stabilising agents for rubber vulcanisates
  申请人：MONSANTO EUROPE S.A.

  公开号：EP0129527A2

  公开（公告）日：1984-12-27

  Additives tor rubber compositions, giving vulcanisates having improved retention of optimum physical properties, are compounds having the formula R-S-B-S-R where B is an organic bridging group and R is an electron-withdrawing group, for example CN, CCl3, a radical containing an activated methylene group linked to the sulphur atom or the enolic tautomer of a keto-activated methylene group. Also useful as stabilising agents are oligomeric analogues of such compounds.

  具有 R-S-B-S-R 式的化合物是橡胶组合物的添加剂，可使硫化胶更好地保持最佳物理性能，其中 B 是有机桥基，R 是抽电子基团，例如 CN、CCl3、含有与硫原子相连的活化亚甲基的自由基或酮活化亚甲基的烯醇同系物。 这类化合物的低聚类似物也可用作稳定剂。