2-(cholestan-3β-yl)ethanamine | 1031890-68-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-(cholestan-3β-yl)ethanamine
• 英文别名: 3β-aminoethyl-5α-cholestane；2-[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]ethanamine
• CAS: 1031890-68-2
• 化学式: C₂₉H₅₃N
• 分子量: 415.747
• InChiKey: BNICBSRNZPZLHZ-LKHYOGBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(cholestan-3β-yl)ethanamine 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 3β-aminoethyl-5α-cholestane hydrochloride
  参考文献：
  名称：

  WO2008/68037

  摘要：

  公开号：
• 作为产物：
  描述：

  5-Alpha-胆甾烷-3-酮 在 lithium aluminium tetrahydride 、 palladium on activated charcoal 、 氢气 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 9.0h， 生成 2-(cholestan-3β-yl)ethanamine
  参考文献：
  名称：

  Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents

  摘要：

  The influenza A virus (IFV) possesses a highly ordered cholesterol-rich lipid envelope. A specific composition and structure of this membrane raft envelope are essential for viral entry into cells and virus budding. Several steroidal amines were investigated for antiviral activity against IFV. Both, a positively charged amino function and the highly hydrophobic (ClogP >= 5.9) ring system are required for IC50 values in the low mu M range. An amino substituent is preferential to an azacyclic A-ring. We showed that these compounds either disrupt or augment membrane rafts and in some cases inactivate the free virus. Some of the compounds also interfere with virus budding. The antiviral selectivity improved in the series 3-amino, 3-aminomethyl, 3-aminoethyl, or by introducing an OH function in the A-ring. Steroidal amines show a new mode of antiviral action in directly targeting the virus envelope and its biological functions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.07.015

文献信息

• WO2008/68037
  申请人：——

  公开号：——

  公开（公告）日：——
• Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents
  作者：Sameer Agarwal、Cornelia Schroeder、Georg Schlechtingen、Tobias Braxmeier、Gary Jennings、Hans-Joachim Knölker

  DOI：10.1016/j.bmcl.2013.07.015

  日期：2013.9

  The influenza A virus (IFV) possesses a highly ordered cholesterol-rich lipid envelope. A specific composition and structure of this membrane raft envelope are essential for viral entry into cells and virus budding. Several steroidal amines were investigated for antiviral activity against IFV. Both, a positively charged amino function and the highly hydrophobic (ClogP >= 5.9) ring system are required for IC50 values in the low mu M range. An amino substituent is preferential to an azacyclic A-ring. We showed that these compounds either disrupt or augment membrane rafts and in some cases inactivate the free virus. Some of the compounds also interfere with virus budding. The antiviral selectivity improved in the series 3-amino, 3-aminomethyl, 3-aminoethyl, or by introducing an OH function in the A-ring. Steroidal amines show a new mode of antiviral action in directly targeting the virus envelope and its biological functions. (C) 2013 Elsevier Ltd. All rights reserved.