3β,16α,17β-triacetoxy-androst-5-ene | 94703-18-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β,16α,17β-triacetoxy-androst-5-ene
• 英文别名: 3β,16α,17β-Triacetoxy-androst-5-en；(10R)-3c,16t,17c-Triacetoxy-10r,13c-dimethyl-(8cH,9tH,14tH)-Δ⁵-tetradecahydro-1H-cyclopenta[a]phenanthren；Androsten-(5)-triyl-(3β,16α,17β)-triacetat；Androst-5-en-3β,16α,17β-triol-triacetat；[(3S,8R,9S,10R,13S,14S,16R,17R)-16,17-diacetyloxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
• CAS: 94703-18-1
• 化学式: C₂₅H₃₆O₆
• 分子量: 432.557
• InChiKey: DGPZKDQQKGWWSJ-DWKSCWABSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3β,16α,17β-triacetoxy-androst-5-ene 在 氢氧化钾 作用下， 生成 5-雄甾烯-3b,16a,17b-三醇
  参考文献：
  名称：

  Huffmann; Lott, Journal of Biological Chemistry, 1946, vol. 164, p. 785

  摘要：

  DOI：
• 作为产物：
  描述：

  3β-acetoxy-5α,6β-dichloro-androsta-17-one 在 硫酸 、 溶剂黄146 、 锌 作用下， 生成 3β,16α,17β-triacetoxy-androst-5-ene
  参考文献：
  名称：

  16氧化ANDROST-5-EN-3-BETA-OL衍生物的合成。

  摘要：

  约有16种含氧的雄甾-5-烯类固醇，它们均为类固醇代谢物，是通过3β-乙酰氧基-5α, 6β-二氯雄甾烷-17-酮制备的。

  DOI：

  10.1248/cpb.12.808

文献信息

• Microwave induced selective enolization of steroidal ketones and efficient acetylation of sterols in semisolid state
  作者：Padma Marwah、Ashok Marwah、Henry A. Lardy

  DOI：10.1016/s0040-4020(03)00207-2

  日期：2003.3

  Under microwave irradiation steroidal enones, more specifically, position three carbonyls were efficiently and selectively converted to the corresponding enol acetates in the presence of additional enolizable carbonyl functions at other positions, using acetic anhydride and a catalytic amount of toluene-p-sulfonic acid. Acetylation of hydroxyl groups of the sterols, including those at the hindered

  在微波辐射下，更具体地，使用乙酸酐和催化量的甲苯-对磺酸，在其他位置存在另外的可烯丙基的羰基官能团的情况下，在其他位置上，将三个位置的羰基化合物有效且选择性地转化为相应的烯醇乙酸酯。固醇的羟基的乙酰化，包括在受阻位置的羟基，几乎是定量的。严格的无水条件不是乙酰化的前提条件，反应系统很容易耐受高达10％（v / v）的水分。
• Hirschmann, Journal of Biological Chemistry, 1943, vol. 150, p. 363,373
  作者：Hirschmann

  DOI：——

  日期：——
• Reconnaissance mapping and management of salt-affected soils using satellite images
  作者：R. C. Sharma、R. K. Saxena、K. S. Verma

  DOI：10.1080/014311600750019831

  日期：2000.1

  The Indo-Gangetic alluvial plain is subjected to large scale soil alkalization. In order to map and characterize salt-affected soils, with the aim of applying management techniques, Etah district in Uttar Pradesh, located between 26 degrees 45' to 28 degrees 02' N and 78 degrees 15' to 79 degrees 20' E was selected. Multidate, high resolution, IRS-LISS II, geocoded FCC images on 1:50 000 scale were used. Integrating visual image interpretation, physiographic analysis, ground data and laboratory analysis of soil samples, a legend for mapping salt-affected soils ( SAS) was formulated. Based on variations in physicochemical properties: nature, intensity and depth wise distribution of salts, five categories of SAS requiring specific reclamation measures were identified. Soil categories S2, S3 and S4 have a gypsum requirement ( GR) of 20, 12 and 4 t/ha(-1) respectively. Reclamation of medium to heavy textured highly alkali soils requires the addition of amendments and a rice-wheat rotation for the initial 3-4 years. Under resource constraints, pit planting of Prosopis juliflora can bring about slow but effective reclamation. The soil category S5 is slightly alkali in the substratum, needing only biological reclamation by growing salt tolerant varieties of rice and wheat crops. Soils of category S1 are saline and need management by hydrological treatments. Incorporation of village boundaries on a map showing SAS would facilitate decision taking in planning reclamation projects and accelarate management operations directly at village level.
• Marrian; Butler, Biochemical Journal, 1944, vol. 38, p. 322,324
  作者：Marrian、Butler

  DOI：——

  日期：——
• Adams et al., Journal of the Chemical Society, 1956, p. 297,299
  作者：Adams et al.

  DOI：——

  日期：——