2-[(dimethylamino)methyl]furo[2,3-c]isoquinolin-5(4H)-one hydrochloride | 1201832-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-[(dimethylamino)methyl]furo[2,3-c]isoquinolin-5(4H)-one hydrochloride
• 英文别名: 2-[(dimethylamino)methyl]-4H-furo[2,3-c]isoquinolin-5-one;hydrochloride
• CAS: 1201832-12-3
• 化学式: C₁₄H₁₄N₂O₂*ClH
• 分子量: 278.738
• InChiKey: FHALNYAIKZCRCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.76
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  45.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-Phenyl-2-furoyl chloride 在 sodium azide 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 、 邻二氯苯 、 乙腈 为溶剂， 反应 10.0h， 生成 2-[(dimethylamino)methyl]furo[2,3-c]isoquinolin-5(4H)-one hydrochloride
  参考文献：
  名称：

  [EN] THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM
  [FR] THIÉNYL-ISOQUINOLINONES ET FURANYL-ISOQUINOLINONES, ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  本发明涉及替代噻吩基和呋喃基异喹啉酮，例如作为多聚腺苷二磷酸核糖聚合酶（PARP）的调节剂。本发明还涉及替代噻吩基和呋喃基异喹啉酮的制备方法，以及它们在治疗各种疾病和疾病中的应用。

  公开号：

  WO2009155413A1

文献信息

• THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM
  申请人：Pellicciari Roberto

  公开号：US20090325951A1

  公开（公告）日：2009-12-31

  The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及替代噻吩基和呋吩基异喹啉酮，例如作为聚(ADP-核糖)聚合酶(PARP)调节剂。本发明还涉及制备替代噻吩基和呋吩基异喹啉酮的过程，以及它们在治疗各种疾病和疾病方面的用途。
• Thienyl- and furanyl-isoquinolinones and methods for using them
  申请人：Pellicciari Roberto

  公开号：US09079915B2

  公开（公告）日：2015-07-14

  The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及取代的噻吩基和呋吩基异喹啉酮，例如作为多聚(ADP-核糖)聚合酶(PARP)调节剂。本发明还涉及制备取代的噻吩基和呋吩基异喹啉酮的方法，以及它们在治疗各种疾病和障碍方面的应用。
• Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them
  申请人：Pellicciari Roberto

  公开号：US20140107117A1

  公开（公告）日：2014-04-17

  The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及替代的噻吩基和呋喃基异喹啉酮，例如作为聚(ADP-核糖)聚合酶（PARP）的调节剂。本发明还涉及制备替代的噻吩基和呋喃基异喹啉酮的方法以及它们在治疗各种疾病和疾患中的应用。
• Thienyl-and furanyl-isoquinolinones and methods for using them
  申请人：Pellicciari Roberto

  公开号：US08633215B2

  公开（公告）日：2014-01-21

  The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及取代噻吩基和呋吩基异喹啉酮，例如作为多聚(ADP-核糖)聚合酶(PARP)调节剂。本发明还涉及制备取代噻吩基和呋吩基异喹啉酮的方法，以及它们在治疗各种疾病和疾患中的用途。
• THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM
  申请人：Pellicciari, Roberto

  公开号：EP2313418B1

  公开（公告）日：2016-03-30