jacareubin | 3811-29-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: jacareubin
• 英文别名: jacareubine；xanthone v1；5,9,10-trihydroxy-2,2-dimethyl-2H-pyrano[3,2-b]xanthen-6-one；5,9,10-trihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one；5,9,10-trihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one
• CAS: 3811-29-8
• 化学式: C₁₈H₁₄O₆
• 分子量: 326.306
• InChiKey: UCLUVPCGXYTYEK-UHFFFAOYSA-N

物化性质

• 熔点：
  256-257 °C (decomp)(Solv: methanol (67-56-1))
• 沸点：
  553.1±50.0 °C(Predicted)
• 密度：
  1.493±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide 、 jacareubin 在 sodium hydroxide 、 丙酮 作用下， 生成 7-hydroxy-10,10-dimethyl-10H-[1,3]dioxolo[4,5-h]pyrano[3,2-b]xanthen-6-one
  参考文献：
  名称：

  King et al., Journal of the Chemical Society, 1953, p. 3932,3935

  摘要：

  DOI：
• 作为产物：
  描述：

  9,10-Dihydroxy-5-methoxy-2,2-dimethyl-2H-pyrano[3,2-b]xanthen-6-one 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 生成 jacareubin
  参考文献：
  名称：

  New Linear Pyranoxanthones from Calophyllum apetalum

  摘要：

  The investigation of chemical constituents in stem bark and root of Calophyllum apetalum (Guttiferae) led to isolate sixteen xanthones and two coumarin derivatives. Among them, two linear pyranoxanthones [caloxanthones I (1) and J (2)] from the stem bark, and two xanthones [caloxanthone K (10) and 1,3,6,8-trihydroxy-2-methoxyxanthone (12)] from the root were new ones. The respective structures were determined by the spectral analysis.

  DOI：

  10.3987/com-96-7652

文献信息

• LIGAND REGULATED PROTEIN-PROTEIN INTERACTION SYSTEM
  申请人：St. Anna Kinderkrebsforschung

  公开号：EP3502130A1

  公开（公告）日：2019-06-26

  Disclosed is a ligand regulated protein-protein interaction system based on a lipocalin-fold molecule comprising: (a) a lipocalin-fold molecule (b) a lipocalin-fold ligand with a low molecular weight of 1500 Da or below, and (c) a lipocalin-fold binding interaction partner, wherein the lipocalin-fold molecule can bind to the lipocalin-fold ligand; and wherein the lipocalin-fold molecule bound to the lipocalin-fold ligand binds to the lipocalin-fold binding interaction partner with an affinity which is at least 10-fold higher than the affinity of the lipocalin-fold molecule not bound to the lipocalin-fold ligand, and wherein the lipocalin-fold binding interaction partner is not a naturally occurring protein which has an affinity of <10 µM to any naturally occurring lipocalin-fold molecule in the presence of any lipocalin-fold ligand.

  所公开的是一种基于脂钙蛋白折叠分子的配体调节蛋白质-蛋白质相互作用系统，该系统包括 (a) 脂钙蛋白折叠分子 (b) 低分子量为 1500 Da 或以下的脂钙蛋白-折叠配体，以及 (c) 脂钙蛋白-折叠结合相互作用伙伴、 其中脂钙素折叠分子可与脂钙素折叠配体结合；以及 其中与脂钙蛋白配体结合的脂钙蛋白-折叠分子与脂钙蛋白-折叠结合相互作用伙伴结合的亲和力比未与脂钙蛋白-折叠配体结合的脂钙蛋白-折叠分子的亲和力至少高 10 倍、 其中脂钙蛋白-折叠结合相互作用伙伴不是天然存在的蛋白质，它在任何脂钙蛋白-折叠配体存在下对任何天然存在的脂钙蛋白-折叠分子的亲和力小于10 µM。
• Coating solution for preventing adhesion of polymer scale and method for its use
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0496349B1

  公开（公告）日：1996-04-10
• JPH04154804A
  申请人：——

  公开号：JPH04154804A

  公开（公告）日：1992-05-27
• A GROUP OF CHIMERIC ANTIGEN RECEPTORS (CARS)
  申请人：ST. ANNA KINDERKREBSFORSCHUNG

  公开号：US20210386781A1

  公开（公告）日：2021-12-16

  A group of chimeric antigen receptors (CARs) having two, three or four CAR molecules, wherein the members of the group of CARs can be different in their amino acid sequences, and wherein each of the CAR molecules of the group includes at least a transmembrane domain and an ectodomain comprising either an antigen binding moiety or a binding site to which another polypeptide is able to bind, wherein the polypeptide comprises an antigen binding moiety; wherein each CAR molecule of the group includes at least one dimerization domain, wherein this dimerization of a pair of dimerization domains is either induced by a regulating molecule and optionally reduced by another regulating molecule, or occurs in the absence of a regulating molecule and is reduced by a regulating molecule, and wherein the antigen binding moieties of the CAR molecules of the group specific for one target antigen.
• US5241022A
  申请人：——

  公开号：US5241022A

  公开（公告）日：1993-08-31