N-(4-叔丁基环己基)苯甲酰胺 | 31865-32-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-叔丁基环己基)苯甲酰胺
• 英文名称: N-(4-(tert-butyl)cyclohexyl)benzamide
• 英文别名: N-(4-tert-Butylcyclohexyl)benzamide
• CAS: 31865-32-4
• 化学式: C₁₇H₂₅NO
• 分子量: 259.392
• InChiKey: WYGMRNJUINLKMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(4-tert-butylcyclohexylidene)hydroxylamine 在 sodium 、 三乙胺 作用下， 以 乙醇 、 苯 为溶剂， 生成 N-(4-叔丁基环己基)苯甲酰胺
  参考文献：
  名称：

  Synthesis of N-[4-(alkyl)cyclohexyl]-substituted benzamides with anti-inflammatory and analgesic activities

  摘要：

  Two series of N-[4-(alkyl)cyclohexyl]-substituted benzamides, i.e. a series of N-[4-(relf-butyl)cyclohexyl]-substituted benzamides and a series of N-[4-(ethyl)cyclohexyl]-substituted benzamides, were synthesised and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability. (C) 1999 Elsevier Science S.A, All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00057-9

文献信息

• Direct Amidation of Carboxylic Acids through an Active α-Acyl Enol Ester Intermediate
  作者：Xianjun Xu、Huangdi Feng、Liliang Huang、Xiaohui Liu

  DOI：10.1021/acs.joc.8b00819

  日期：2018.8.3

  The development of a highly efficient and simple protocol for the direct amidation of carboxylic acids is described employing ynoates as novel coupling reagents. The transformation proceeds in good to excellent yields via in situ α-acyl enol ester intermediates formation under mild reaction conditions. This useful method has been demonstrated for a range of substrates to provide a succinct access to

  描述了使用壬酸酯作为新型偶联剂来开发用于羧酸的直接酰胺化的高效且简单的方案。通过在温和的反应条件下原位形成α-酰基烯醇酯中间体，可将转化率以良好至极好的收率进行。已经证明了这种有用的方法可用于多种底物，以提供对结构多样的酰胺的简洁访问，包括格列本脲，替阿必利盐酸盐和那格列奈的关键中间体，并且可以以摩尔规模进行。
• PYRIMIDINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150065505A1

  公开（公告）日：2015-03-05

  The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

  本发明提供了公式（I）所定义的化合物，以及包含任何此类新型化合物的组合物。这些化合物是内皮细胞脂肪酶抑制剂，可用作药物。
• US9199946B2
  申请人：——

  公开号：US9199946B2

  公开（公告）日：2015-12-01
• Synthesis of N-[4-(alkyl)cyclohexyl]-substituted benzamides with anti-inflammatory and analgesic activities
  作者：Amedeo Pau、Gianpiero Boatto、Michele Palomba、Battistina Asproni、Riccardo Cerri、Francesco Palagiano、Walter Filippelli、Giuseppe Falcone、Giulia Motola

  DOI：10.1016/s0014-827x(99)00057-9

  日期：1999.8

  Two series of N-[4-(alkyl)cyclohexyl]-substituted benzamides, i.e. a series of N-[4-(relf-butyl)cyclohexyl]-substituted benzamides and a series of N-[4-(ethyl)cyclohexyl]-substituted benzamides, were synthesised and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability. (C) 1999 Elsevier Science S.A, All rights reserved.