(羟氨基)甲醇 | 115750-71-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (羟氨基)甲醇
• 英文名称: oxymethyl hydroxylamine
• 英文别名: N-(2-hydroxylethylamine)；Methanol, (hydroxyamino)-；(hydroxyamino)methanol
• CAS: 115750-71-5
• 化学式: CH₅NO₂
• 分子量: 63.0562
• InChiKey: OUGMWBAPHWXBFS-UHFFFAOYSA-N

物化性质

• 沸点：
  266.1±35.0 °C(Predicted)
• 密度：
  1.290±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  4
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-溴-2,3-二氟苯甲醛 、 (羟氨基)甲醇 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以91%的产率得到
  参考文献：
  名称：

  一种环状氨基嘧啶衍生物及其抑制激酶的活 性和用途

  摘要：

  一种环状氨基嘧啶衍生物及其抑制激酶的活性和用途本发明公开了一种环状氨基嘧啶衍生物，具有通式（Ⅰ）结构，其药学上可接受的盐、酯或溶剂化合物，所述衍生物能抑制激酶的活性，是多种激酶抑制剂，可更广泛地用于癌症的治疗，具有巨大的临床应用前景。通式（I）。

  公开号：

  CN111269245B

文献信息

• Cytotoxicity of New Selenoimine, Selenonitrone and Nitrone Derivatives Against Human Breast Cancer MDA-MB231 Cells
  作者：Batool Haddad、Ali Al-Shawi

  DOI：10.21608/ejchem.2020.31747.2675

  日期：2020.7.13

  A series of new nitrone, selenoimine and selenonitrone derivatives were synthesized. Nitrone and selenonitrone derivatives were synthesized through the condensation reaction between N-mono substitutedhydroxylamine and carbonyl compounds substituted with electron donating groups, such as di(4-methoxy)benzoyl diselenide, 4-(N, N-dimethylamino) benzoyl selenonitrile and 4, 4'-di(N, N- dimethylamino)benzil, afforded a variety of new nitrone and selenonitrone compounds. Selenoimine derivative was synthesized through the condensation reaction between tert-butyl amine and (4-methoxybenzoyl selenonitrile). The yield of synthesized compounds (N-1, N-2, N-3, N-4 and N-5 were (66, 60, 61, 62 and 45) %, respectively. The structures of the synthesized compounds were characterized by FT-IR, H-1-NMR, C-13-NMR, and mass spectra. Cytotoxicity of selenonitrone (N-1) and selenoimine (N-3) derivatives against breast cancer cells (MDA-MB231) were evaluated for 24 and 48 h via MTT assay. The IC50 value of compound N-1 was 1.714 and 1.897 mu M for 24 h and 48 h, respectively. The IC50 value of compound N-3 was 1.438 and 2.469 mu M for 24 h and 48 h, respectively. The results suggested selenonitrone (N-1) and selenoimine (N-3) as anti-breast cancer potential lead compound with future merit investigations.