6-trans-styryl-nicotinic acid methyl ester | 10165-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-trans-styryl-nicotinic acid methyl ester
• 英文别名: 6-trans-Styryl-nicotinsaeure-methylester；methyl 6-[(E)-2-phenylethenyl]pyridine-3-carboxylate
• CAS: 10165-85-2
• 化学式: C₁₅H₁₃NO₂
• 分子量: 239.274
• InChiKey: YSGRTJCNQLDUPU-VQHVLOKHSA-N

物化性质

• 沸点：
  373.5±21.0 °C(Predicted)
• 密度：
  1.174±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 6-trans-styryl-nicotinic acid methyl ester
  参考文献：
  名称：

  Plieninger et al., Chemische Berichte, 1958, vol. 91, p. 1898,1902

  摘要：

  DOI：

文献信息

• Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
  申请人：——

  公开号：US20030064979A1

  公开（公告）日：2003-04-03

  This invention relates to oxalylamide inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al, Proc Natl Acad Sci USA 87: 2735-2789 (1989)) and a method of inhibiting such PTPases by exposing the enzyme to inhibitor compounds of formula 1 1 This invention also relates to (I) the design and selection of inhibitors, which bind to the active site of PTP1B and/or TC-PTP and/or PTPases having an aspartic acid (Asp) in position 48 (II) the synthesis of said inhibitors, methods for their preparation and (III) to compositions comprising the inhibitor compounds.

  这项发明涉及草酸酰胺抑制剂蛋白酪氨酸磷酸酶1B（PTP1B）和/或T细胞蛋白酪氨酸磷酸酶（TC-PTP）和/或蛋白酪氨酸磷酸酶（PTPases），在第48位具有天冬氨酸（Asp）（PTP1B编号，Chernoff等人，Proc Natl Acad Sci USA87: 2735-2789（1989）），以及通过将酶暴露于化合物11的抑制剂来抑制这些PTPases的方法。这项发明还涉及（I）设计和选择结合PTP1B和/或TC-PTP和/或在第48位具有天冬氨酸（Asp）的PTPases活性位点的抑制剂，（II）合成所述抑制剂，其制备方法和（III）包含抑制剂化合物的组合物。
• Vinyl phenyl derivatives as GLK activators
  申请人：Hayter Raymond Barry

  公开号：US20070093535A1

  公开（公告）日：2007-04-26

  The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R 1 , R 2 , R 3 , n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

  该发明涉及公式（I）的新化合物或其盐，溶剂化合物或前药，其中A，R1，R2，R3，n和m如规范中所述，可用于治疗通过葡萄糖激酶（GLK）介导的疾病或症状，例如2型糖尿病。该发明还涉及制备公式（I）化合物的方法以及它们作为药物在治疗通过葡萄糖激酶介导的疾病中的使用。
• METHOD OF INHIBITING PTP 1B AND/OR T-CELL PTP AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48
  申请人：Novo Nordisk A/S

  公开号：EP1404682A1

  公开（公告）日：2004-04-07
• US7199140B2
  申请人：——

  公开号：US7199140B2

  公开（公告）日：2007-04-03
• [EN] METHOD OF INHIBITING PTP 1B AND/OR T-CELL PTP AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48<br/>[FR] PROCEDE PERMETTANT D'INHIBER PTP1B ET / OU PTP DE LYMPHOCYTE T ET / OU D'AUTRES PTPASES A RESTE ASP EN POSITION 48
  申请人：NOVO NORDISK AS

  公开号：WO2003002569A1

  公开（公告）日：2003-01-09

  This invention relates to oxalylamide inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al., Proc. Natl. Acad. Sci. USA 87: 2735-2789 (1989)) and a method of inhibiting such PTPases by exposing the enzyme to inhibitor compounds of formula 1. This invention also relates to (I) the design and selection of inhibitors, which bind to the active site of PTP1B and/or TC-PTP and/or PTPases having an aspartic acid (Asp) in position 48 (II) the synthesis of said inhibitors, methods for their preparation and (III) to compositions comprising the inhibitor compounds.