1-[4-(5-hydroxy-2-naphthyl)phenyl]ethanone | 1268826-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[4-(5-hydroxy-2-naphthyl)phenyl]ethanone
• 英文别名: 1-[4-(5-Hydroxynaphthalen-2-yl)phenyl]ethanone
• CAS: 1268826-23-8
• 化学式: C₁₈H₁₄O₂
• 分子量: 262.308
• InChiKey: MIMUZYPRSGFIFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-羟基-1-四氢萘酮 在 吡啶 、 盐酸 、 四(三苯基膦)钯 、 溴 、 lithium carbonate 、 caesium carbonate 、 lithium bromide 作用下， 以 四氯化碳 、 乙二醇二甲醚 、 乙醚 、 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 1-[4-(5-hydroxy-2-naphthyl)phenyl]ethanone
  参考文献：
  名称：

  17β-HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffold

  摘要：

  17 beta-Hydroxysteroid dehydrogenase type 2 (17 beta-HSD2) catalyses the conversion of active 17 beta-hydroxysteroids into the less active 17-ketosteroids thereby controlling the availability of biologically active estrogens (E2) and androgens (T) in the tissues. The skeletal disease osteoporosis occurs mainly in post-menopausal women and in elderly men when the levels of estrogens and androgens, respectively, decrease. Since 17 beta-HSD2 is present in osteoblasts, inhibition of this enzyme may provide a new and promising approach to prevent the onset of osteoporosis, keeping a certain level in estrogens and androgens in bone cells of ageing people. Hydroxynaphthyl, hydroxyphenyl and hydroxymethylphenyl-substituted moieties were synthesised as mimetics of the steroidal substrate. Compound 8 has been identified as promising scaffold for 17 beta-HSD2 inhibitors displaying high activity and good selectivity toward 17 beta-HSD1, ER alpha and ER beta. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.013