(2-(4-(4-methylthio)phenyl)-5-tosylphenyl)pyridine | 1571060-24-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-(4-(4-methylthio)phenyl)-5-tosylphenyl)pyridine
• 英文别名: 2-[5-(4-Methylphenyl)sulfonyl-2-(4-methylsulfanylphenyl)phenyl]pyridine；2-[5-(4-methylphenyl)sulfonyl-2-(4-methylsulfanylphenyl)phenyl]pyridine
• CAS: 1571060-24-6
• 化学式: C₂₅H₂₁NO₂S₂
• 分子量: 431.579
• InChiKey: MQNNQHZVBQGQGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  80.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(3-tosylphenyl)pyridine 在 四(三苯基膦)钯 、 1,2-二溴四氯乙烷 、 copper diacetate 、 potassium carbonate 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 36.0h， 生成 (2-(4-(4-methylthio)phenyl)-5-tosylphenyl)pyridine
  参考文献：
  名称：

  Sequential Chelation-Assisted Aromatic C–H Functionalisation via Catalytic meta Sulfonation

  摘要：

  The sequential functionalisation of 2-phenylpyridine is presented using selective ortho- and meta-directing processes. It was found that performing a reaction sequence with meta functionalisation first followed by ortho functionalisation provided novel reaction products in good yields and with complete regioselectivity.

  DOI：

  10.1055/s-0033-1340011

文献信息

• Sequential Chelation-Assisted Aromatic C–H Functionalisation via Catalytic meta Sulfonation
  作者：Christopher Frost、William Reynolds、Po Liu、Gabriele Kociok-Köhn

  DOI：10.1055/s-0033-1340011

  日期：——

  The sequential functionalisation of 2-phenylpyridine is presented using selective ortho- and meta-directing processes. It was found that performing a reaction sequence with meta functionalisation first followed by ortho functionalisation provided novel reaction products in good yields and with complete regioselectivity.