1,5-anhydro-4,6-di-O-pivaloyl-2-(adenine-9-yl)-2,3-dideoxy-D-glucitol | 383859-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1,5-anhydro-4,6-di-O-pivaloyl-2-(adenine-9-yl)-2,3-dideoxy-D-glucitol
• CAS: 383859-46-9
• 化学式: C₂₁H₃₁N₅O₅
• 分子量: 433.508
• InChiKey: IPCDKAWCHDYLGW-HZSPNIEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  31.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  131.45
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  1,5-anhydro-4,6-di-O-pivaloyl-2-(adenine-9-yl)-2,3-dideoxy-D-glucitol 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以55%的产率得到1,5-anhydro-2-(adenin-9-yl)-2,3-dideoxy-D-glucitol
  参考文献：
  名称：

  Hybridization between “Six-Membered” Nucleic Acids:  RNA as a Universal Information System

  摘要：

  [GRAPHICS]Within the polyA:polyT recognition system, cross-pairing between several nucleic acids with a phosphorylated six-membered carbohydrate (mimic) as repeating unit in the backbone structure has been observed. All investigated nucleic acids (except for beta -homo-DNA) hybridize with RNA, leaving RNA as a versatile biopolymer for informational transfer.

  DOI：

  10.1021/ol016183r
• 作为产物：
  描述：

  1,5-anhydro-2-O-tosyl-3-deoxy-D-mannitol 在 吡啶 、 12-冠醚-4 、 lithium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 1,5-anhydro-4,6-di-O-pivaloyl-2-(adenine-9-yl)-2,3-dideoxy-D-glucitol
  参考文献：
  名称：

  Hybridization between “Six-Membered” Nucleic Acids:  RNA as a Universal Information System

  摘要：

  [GRAPHICS]Within the polyA:polyT recognition system, cross-pairing between several nucleic acids with a phosphorylated six-membered carbohydrate (mimic) as repeating unit in the backbone structure has been observed. All investigated nucleic acids (except for beta -homo-DNA) hybridize with RNA, leaving RNA as a versatile biopolymer for informational transfer.

  DOI：

  10.1021/ol016183r