benzyl 2,4,5-trichlorophenyl sulfide | 96460-46-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: benzyl 2,4,5-trichlorophenyl sulfide
• 英文别名: benzyl-(2,4,5-trichloro-phenyl)-sulfide；Benzyl-(2,4,5-trichlor-phenyl)-sulfid；1-benzylsulfanyl-2,4,5-trichlorobenzene
• CAS: 96460-46-7
• 化学式: C₁₃H₉Cl₃S
• 分子量: 303.639
• InChiKey: AGDFAVPMRFUMSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.94
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  2,4,5-三氯苯硫醇 在 四氯化锡 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 benzyl 2,4,5-trichlorophenyl sulfide
  参考文献：
  名称：

  Tamura, Yasumitsu; Annoura, Hirokazu; Fuji, Masahiro, Chemical and pharmaceutical bulletin, 1986, vol. 34, # 2, p. 540 - 549

  摘要：

  DOI：

文献信息

• An Innovative Approach to Clinical Communication in Schizophrenia: The Approaches to Schizophrenia Communication Checklists
  作者：Sharon G. Dott、Peter Weiden、Penelope Hopwood、A. George Awad、Jonathan S.E. Hellewell、John Knesevich、Lili Kopala、Alexander Miller、Carl Salzman

  DOI：10.1017/s1092852900022045

  日期：2001.11

  Side effects from antipsychotic medications can have a profound effect on patients' lives and may adversely affect their willingness to comply with treatment. Identification of side effects through improved communication between psychiatrists, other members of the healthcare team, and their patients might increase treatment compliance. The Approaches to Schizophrenia Communication (ASC) Steering Group developed two simple, practical checklists for use in the busy clinical setting. The ASC–Self-Report (ASC-SR) checklist is completed by the patient and comprises a list of the more common or clinically important side effects of antipsychotic treatment. The ASC-Clinic (ASC-C) checklist is completed by both clinician and patient together, being used as the basis for a semi-structured interview. In a multicenter pilot study set up to evaluate the utility of checklists, 86% of patients responding considered the ASC-SR to be useful in communicating their problems to psychiatrists and other members of the healthcare team. All healthcare team respondents found both checklists to be helpful when discussing side effect problems with their patients. Moreover, 41% and 47% of healthcare team respondents reported that the ASC-SR and ASC-C, respectively, had assisted them in identifying side-effect problems not previously acknowledged. Preliminary evaluation of the ASC-SR and ASC-C in this multicenter pilot study suggests that both tools were user-friendly, encouraged communication between patients and healthcare professionals about antipsychotic drug side effects, and could readily integrated into everyday clinical practice.

  摘要抗精神病药物的副作用会对患者的生活产生深远的影响，并可能对他们遵从治疗的意愿产生不利影响。通过改善精神科医生、医疗团队其他成员和患者之间的沟通来识别副作用，可能会提高治疗依从性。精神分裂症沟通方法（ASC）指导小组开发了两份简单实用的核对表，可在繁忙的临床环境中使用。ASC-自我报告（ASC-SR）核对表由患者填写，包含一份抗精神病治疗中较为常见或临床上较为重要的副作用清单。ASC-临床（ASC-C）核对表由临床医生和患者共同完成，作为半结构化访谈的基础。在一项为评估核对表效用而设立的多中心试点研究中，86%的受访患者认为 ASC-SR 有助于向精神科医生和医疗团队的其他成员传达他们的问题。所有医疗团队的受访者都认为这两份核对表有助于他们与患者讨论副作用问题。此外，分别有 41% 和 47% 的医疗团队受访者表示，ASC-SR 和 ASC-C 有助于他们发现之前没有意识到的副作用问题。这项多中心试点研究对ASC-SR和ASC-C的初步评估表明，这两种工具对用户都很友好，能鼓励患者和医护人员就抗精神病药物的副作用进行交流，并能很容易地融入日常临床实践中。
• TAMURA, YASUMITSU;ANNOURA, HIROKAZU;FUJI, MASAHIRO;OKURA, MASAMI;ISHIBASH+, CHEM. AND PHARM. BULL., 1986, 34, N 2, 540-549
  作者：TAMURA, YASUMITSU、ANNOURA, HIROKAZU、FUJI, MASAHIRO、OKURA, MASAMI、ISHIBASH+

  DOI：——

  日期：——