3-(1-Hexenyl)-5-methyl-2-(5h)-furanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 3-(1-Hexenyl)-5-methyl-2-(5h)-furanone
• 英文别名: 4-hex-1-enyl-2-methyl-2H-furan-5-one
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: OVEBWDPQALSVNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (R)-methyl 4-hydroxypent-2-ynoate 、 1-hexenylboronic acid 在 palladium diacetate 三叔丁基膦 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 3-(1-Hexenyl)-5-methyl-2-(5h)-furanone 、 3-hex-1-enyl-2-methyl-2H-furan-5-one
  参考文献：
  名称：

  Regioselective Pd-catalyzed alkylative lactonizations of 4-hydroxy-2-alkynecarboxylates with organoboronic acids

  摘要：

  The palladium-catalyzed addition of aryl- and alkenylboronic acids to 4-hydroxy-2-alkynecarboxylates and in situ lactonization would constitute a novel methodology for the synthesis of various butenolides with an excellent stereoselectivity and a high control of regioselectivity. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2004.07.129

文献信息

• Regioselective Pd-catalyzed alkylative lactonizations of 4-hydroxy-2-alkynecarboxylates with organoboronic acids
  作者：Chang Ho Oh、Su Jin Park、Jin Hyang Ryu、Arun Kumar Gupta

  DOI：10.1016/j.tetlet.2004.07.129

  日期：2004.9

  The palladium-catalyzed addition of aryl- and alkenylboronic acids to 4-hydroxy-2-alkynecarboxylates and in situ lactonization would constitute a novel methodology for the synthesis of various butenolides with an excellent stereoselectivity and a high control of regioselectivity. (C) 2004 Published by Elsevier Ltd.