ethyl (2E,4E)-5-[4-hydroxy-3-methoxyphenyl]penta-2,4-dienoate | 1093121-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: ethyl (2E,4E)-5-[4-hydroxy-3-methoxyphenyl]penta-2,4-dienoate
• 英文别名: ethyl (2E,4E)-5-(4-hydroxy-3-methoxyphenyl)penta-2,4-dienoate
• CAS: 1093121-07-3
• 化学式: C₁₄H₁₆O₄
• 分子量: 248.279
• InChiKey: PUJCEZJWDNZNSK-YDFGWWAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl (2E,4E)-5-[4-hydroxy-3-methoxyphenyl]penta-2,4-dienoate 在 氢氧化钾 、 水 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以90%的产率得到(2E,4E)-5-(4-hydroxy-3-methoxyphenyl)penta-2,4-dienoic acid
  参考文献：
  名称：

  Synthesis of New Avenalumic Carboxamide Derivatives in the Ferulic Series

  摘要：

  A seven-step synthesis of (2E,4E)-5-[4-hydroxy-3-methoxyphenyl]penta-2,4-dienoic acid from ferulic acid was developed. The use of a natural by-product found in rice bran as a raw material provided the ferulic acid vinylogous in an overall high yield. This compound will be useful for the preparation of a wide variety of avenalumic carboxamide derivatives.

  DOI：

  10.1080/00397910802238817
• 作为产物：
  描述：

  (2E,4E)-5-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]-penta-2,4-dienoate 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以93%的产率得到ethyl (2E,4E)-5-[4-hydroxy-3-methoxyphenyl]penta-2,4-dienoate
  参考文献：
  名称：

  Synthesis of New Avenalumic Carboxamide Derivatives in the Ferulic Series

  摘要：

  A seven-step synthesis of (2E,4E)-5-[4-hydroxy-3-methoxyphenyl]penta-2,4-dienoic acid from ferulic acid was developed. The use of a natural by-product found in rice bran as a raw material provided the ferulic acid vinylogous in an overall high yield. This compound will be useful for the preparation of a wide variety of avenalumic carboxamide derivatives.

  DOI：

  10.1080/00397910802238817

文献信息

• Synthesis of New Avenalumic Carboxamide Derivatives in the Ferulic Series
  作者：Marc-Antoine Bazin、Laïla El Kihel、Marie Jouanne、Jean-Charles Lancelot、Sylvain Rault

  DOI：10.1080/00397910802238817

  日期：2008.10.28

  A seven-step synthesis of (2E,4E)-5-[4-hydroxy-3-methoxyphenyl]penta-2,4-dienoic acid from ferulic acid was developed. The use of a natural by-product found in rice bran as a raw material provided the ferulic acid vinylogous in an overall high yield. This compound will be useful for the preparation of a wide variety of avenalumic carboxamide derivatives.