3-(Bromomethyl)-2-nitrobenzoic acid | 920760-14-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(Bromomethyl)-2-nitrobenzoic acid
• CAS: 920760-14-1
• 化学式: C₈H₆BrNO₄
• 分子量: 260.044
• InChiKey: FOMMPVJYOGJALW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(Bromomethyl)-2-nitrobenzoic acid 、 (7S)-7-氨基-1,2,3-三甲氧基-10-甲硫基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-(bromomethyl)-2-nitro-N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]benzamide
  参考文献：
  名称：

  Design, synthesis and identification of novel colchicine-derived immunosuppressant

  摘要：

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.054
• 作为产物：
  描述：

  3-(溴甲基)-2-硝基苯甲酸甲酯 在 水 作用下， 以 甲醇 为溶剂， 生成 3-(Bromomethyl)-2-nitrobenzoic acid 、 3-(hydroxymethyl)-2-nitrobenzoic acid
  参考文献：
  名称：

  Design, synthesis and identification of novel colchicine-derived immunosuppressant

  摘要：

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.054

文献信息

• Novel tricyclic derivatives and their use
  申请人：Chang Dong Jo

  公开号：US20070021427A1

  公开（公告）日：2007-01-25

  The present invention relates to tricyclic colchicine derivatives represented by the formulas (I) or (II), pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an anti-inflammatory effect or a method for treating cancer comprising administering to a patient an effective amount of one or more colchicine derivatives:

  本发明涉及三环秋水仙素衍生物，其公式表示为(I)或(II)，以及其药学上可接受的盐，以及提供免疫抑制或免疫调节作用、抗增殖作用、抗炎作用或治疗癌症的方法，包括向患者施用一种或多种秋水仙素衍生物的有效量。
• US5482719A
  申请人：——

  公开号：US5482719A

  公开（公告）日：1996-01-09
• US5565324A
  申请人：——

  公开号：US5565324A

  公开（公告）日：1996-10-15
• US7622612B2
  申请人：——

  公开号：US7622612B2

  公开（公告）日：2009-11-24
• [EN] CROP-SELECTIVE HERBICIDAL SULFONAMIDES
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：WO1991015478A1

  公开（公告）日：1991-10-17

  (EN) This invention relates to novel sulfonamides and their use as crop selective herbicides. Compounds of the instant invention have demonstrated excellent control of weeds coupled with corn safety.(FR) Nouveaux sulfonamides et leur emploi en tant qu'herbicides sélectifs. Les composés de l'invention présentent une excellente maîtrise des mauvaises herbes sans constituer de danger pour les céréales.