4-(4-bromophenyl)-6-(4-chlorophenyl)-2,2'-bipyridine | 1384168-24-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(4-bromophenyl)-6-(4-chlorophenyl)-2,2'-bipyridine
• 英文别名: 4-(4-bromophenyl)-2-(4-chlorophenyl)-6-pyridin-2-ylpyridine
• CAS: 1384168-24-4
• 化学式: C₂₂H₁₄BrClN₂
• 分子量: 421.724
• InChiKey: LJOBFAOMMLNASJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  sodium tetrachloropalladate(II) 、 4-(4-bromophenyl)-6-(4-chlorophenyl)-2,2'-bipyridine 在 HCl 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Interaction of palladium(II) coordination compounds with calf thymus DNA and their antibacterial activity

  摘要：

  The palladium(II) complexes of the formulations [Pd(clpbpy)Cl-2], [Pd(clcpbpy)Cl-2], [Pd(brcpbpy)Cl-2], [Pd(clmpbpy)Cl-2] {clpbpy=4-(4-chlorophenyl)-6-phenyl-2,2'-bipyridine (L-1), clcpbpy=4,6-bis(4-chlorophenyl)-2,2'-bipyridine (L-2), brcpbpy=4-(4-bromophenyl)-6-(4-chlorophenyl)-2,2'-bipyridine (L-3) and clmpbpy=6-(4-chlorophenyl)-4-p-tolyl-2,2'-bipyridine (L-4)} have been synthesized and characterized using elemental analysis, electronic spectra. IR and mass spectra. The study on the interaction of the palladium complexes with calf thymus DNA (CT DNA) has been performed using absorption titration, viscosity measurements and thermal denaturation techniques. The study suggests the intercalative mode of DNA binding. Gel electrophoresis assay demonstrates the ability of the complexes to cleave the pUC19 DNA. The antibacterial activity of complexes has been screened against two Gram((+ve)) and three Gram((-ve)) microorganisms. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2012.04.011
• 作为产物：
  描述：

  4-氯苯甲醛 在 ammonium acetate 作用下， 以 甲醇 为溶剂， 生成 4-(4-bromophenyl)-6-(4-chlorophenyl)-2,2'-bipyridine
  参考文献：
  名称：

  联吡啶的方形平面钯 (II) 配合物：合成、表征和生物学研究

  摘要：

  一系列方形平面单核钯 (II) 配合物，[Pd(L n )(OMe)2]（其中 L n = 4-(4-氯苯基)-6-苯基-2,2'-联吡啶，4,6 -双(4-氯苯基)-2,2'-联吡啶、4-(4-溴苯基)-6-(4-氯苯基)-2,2'-联吡啶和6-(4-氯苯基)-4-p -tolyl-2,2'-bipyridine)，已被合成和表征。钯配合物与 DNA 的相互作用已通过电子吸收光谱、粘度测量和 DNA 熔解温度技术进行了研究。金属络合物-DNA 相互作用产生低色度和红度色，表明嵌入结合。粘度数据支持结合的插层模式。钯 (II) 复合物促进质粒 pUC19 DNA 从超螺旋形式切割为开环形式。还评估了复合物对五种病原菌的抗菌活性。抗菌测试结果表明，与配体和金属盐相比，所有化合物对革兰氏 (-ve) 和革兰 (+ve) 细菌物种均具有良好的抗菌活性。

  DOI：

  10.1080/00958972.2012.727207

文献信息

• Square planar palladium(II) complexes of bipyridines: synthesis, characterization, and biological studies
  作者：Mohan N. Patel、Promise A. Dosi、Bhupesh S. Bhatt

  DOI：10.1080/00958972.2012.727207

  日期：2012.11.10

  2′-bipyridine, and 6-(4-chlorophenyl)-4-p-tolyl-2,2′-bipyridine), have been synthesized and characterized. Interaction of palladium complexes with DNA has been investigated by electronic absorption spectra, viscosity measurements and DNA melting temperature techniques. The metal complex-DNA interaction produced hypochromism and bathochromism, suggesting intercalative binding. Viscosity data support the

  一系列方形平面单核钯 (II) 配合物，[Pd(L n )(OMe)2]（其中 L n = 4-(4-氯苯基)-6-苯基-2,2'-联吡啶，4,6 -双(4-氯苯基)-2,2'-联吡啶、4-(4-溴苯基)-6-(4-氯苯基)-2,2'-联吡啶和6-(4-氯苯基)-4-p -tolyl-2,2'-bipyridine)，已被合成和表征。钯配合物与 DNA 的相互作用已通过电子吸收光谱、粘度测量和 DNA 熔解温度技术进行了研究。金属络合物-DNA 相互作用产生低色度和红度色，表明嵌入结合。粘度数据支持结合的插层模式。钯 (II) 复合物促进质粒 pUC19 DNA 从超螺旋形式切割为开环形式。还评估了复合物对五种病原菌的抗菌活性。抗菌测试结果表明，与配体和金属盐相比，所有化合物对革兰氏 (-ve) 和革兰 (+ve) 细菌物种均具有良好的抗菌活性。
• Interaction of palladium(II) coordination compounds with calf thymus DNA and their antibacterial activity
  作者：Mohan N. Patel、Promise A. Dosi、Bhupesh S. Bhatt

  DOI：10.1016/j.inoche.2012.04.011

  日期：2012.7

  The palladium(II) complexes of the formulations [Pd(clpbpy)Cl-2], [Pd(clcpbpy)Cl-2], [Pd(brcpbpy)Cl-2], [Pd(clmpbpy)Cl-2] clpbpy=4-(4-chlorophenyl)-6-phenyl-2,2'-bipyridine (L-1), clcpbpy=4,6-bis(4-chlorophenyl)-2,2'-bipyridine (L-2), brcpbpy=4-(4-bromophenyl)-6-(4-chlorophenyl)-2,2'-bipyridine (L-3) and clmpbpy=6-(4-chlorophenyl)-4-p-tolyl-2,2'-bipyridine (L-4)} have been synthesized and characterized using elemental analysis, electronic spectra. IR and mass spectra. The study on the interaction of the palladium complexes with calf thymus DNA (CT DNA) has been performed using absorption titration, viscosity measurements and thermal denaturation techniques. The study suggests the intercalative mode of DNA binding. Gel electrophoresis assay demonstrates the ability of the complexes to cleave the pUC19 DNA. The antibacterial activity of complexes has been screened against two Gram((+ve)) and three Gram((-ve)) microorganisms. (C) 2012 Elsevier B.V. All rights reserved.