N-(8-氨基辛基)-1,8-辛烷二胺 | 39202-36-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(8-氨基辛基)-1,8-辛烷二胺
• 英文名称: N-(8-aminooctyl)-1,8-octanediamine
• 英文别名: 1,17-diamino-9-azaheptadecane；bis(8‐aminooctyl)amine；iminodi(octamethylene)diamine；dioctamethylene triamine；Bis(8-aminooctyl)amine；N'-(8-aminooctyl)octane-1,8-diamine
• CAS: 39202-36-3
• 化学式: C₁₆H₃₇N₃
• 分子量: 271.49
• InChiKey: ZWZITQBHEXYRNP-UHFFFAOYSA-N

物化性质

• 沸点：
  190 °C(Press: 3 Torr)
• 密度：
  0.879±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 危险等级：
  8
• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R34
• 包装等级：
  III
• 危险品运输编号：
  UN 3259

反应信息

• 作为反应物：
  描述：

  N-(8-氨基辛基)-1,8-辛烷二胺 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 32.0h， 生成 tert‐butyl N‐({[8‐({8‐[({[(tert‐butoxy)carbonyl]amino}({[(tert‐butoxy)carbonyl]imino})methyl)amino]octyl}amino)octyl]amino}({[(tert‐butoxy)carbonyl]imino})methyl)‐N‐methylcarbamate
  参考文献：
  名称：

  Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

  摘要：

  Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and the lack of new antibiotics is becoming a global emergency. Therefore, research in antibacterial fields is urgently needed to expand the currently available arsenal of drugs. We have recently reported an alkyl-guanidine derivative (2), characterized by a symmetrical dimeric structure, as a good candidate for further developments, with a high antibacterial activity against both Gram-positive and Gram-negative strains. In this study, starting from its chemical scaffold, we synthesized a small library of analogues. Moreover, biological and in vitro pharmacokinetic characterizations were conducted on some selected derivatives, revealing notable properties: broad-spectrum profile, activity against resistant clinical isolates, and appreciable aqueous solubility. Interestingly, 2 seems neither to select for resistant strains nor to macroscopically alter the membranes, but further studies are required to determine the mode of action.

  DOI：

  10.1021/acs.jmedchem.8b00619
• 作为产物：
  描述：

  1,8-辛二胺 在 钯 作用下， 反应 12.0h， 以73%的产率得到N-(8-氨基辛基)-1,8-辛烷二胺
  参考文献：
  名称：

  Catalytic alkyl group exchange reaction of primary and secondary amines

  摘要：

  DOI：

  10.1021/ja00353a025

文献信息

• [EN] NEW BORANOPHOSPHATE ANALOGUES OF CYCLIC NUCLEOTIDES<br/>[FR] NOUVEAUX ANALOGUES BORANOPHOSPHATES DE NUCLÉOTIDES CYCLIQUES
  申请人：BIOLOG LIFE SCIENCE INST FORSCHUNGSLABOR UND BIOCHEMICA VERTRIEB GMBH

  公开号：WO2012130829A1

  公开（公告）日：2012-10-04

  The present invention relates to novel boranophosphate analogues of cyclic nucleotides. The invention further relates to the use of such compounds as reagents for signal transduction research or as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and/or as hydrolysis- and oxidation-resistant ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces and/or as additive for organ transplantation storage solutions.

  本发明涉及新型硼磷酸酯类环核苷酸类似物。该发明进一步涉及将这类化合物用作信号转导研究的试剂或用作调节环核苷酸调控的结合蛋白和同工酶的调节剂，和/或用作亲和层析的水解和氧化抗性配体，用于抗体生产或诊断应用，例如在芯片表面，和/或作为器官移植保存溶液的添加剂。
• FUNCTIONALIZED MONOMERS AND POLYMERS
  申请人：DiBiase Stephen Augustine

  公开号：US20120245063A1

  公开（公告）日：2012-09-27

  This invention relates to a composition, comprising: an unsaturated functionalized monomer of from about 5 to about 30 carbon atoms, which is: (a) polymerized to form a functionalized polymer; (b) copolymerized with a comonomer to form a functionalized copolymer; or (c) reacted with an enophilic reagent to form a polyfunctionalized monomer. The polyfunctionalized monomer may be polymerized to form a polyfunctionalized polymer which may be further reacted with one or more additional reagents. The invention relates to lubricants, functional fluids, fuels, dispersants, detergents and polymeric resins.

  这项发明涉及一种组合物，包括：一个由约5至约30个碳原子的不饱和官能化单体组成，该单体：(a)聚合形成官能化聚合物；(b)与共聚单体共聚形成官能化共聚物；或(c)与亲亚烯试剂反应形成多官能单体。多官能单体可以聚合形成多官能聚合物，该聚合物可以进一步与一个或多个额外试剂反应。该发明涉及润滑剂、功能流体、燃料、分散剂、清洁剂和聚合树脂。
• Diamine and Triamine Analogs and Derivatives as Inhibitors of Deoxyhypusine Synthase: Synthesis and Biological Activity
  作者：Young Bok Lee、Myung Hee Park、J. E. Folk

  DOI：10.1021/jm00016a008

  日期：1995.8

  of this enzyme. The findings indicate that the long chain triamines 2a and 2b and their guanyl derivatives 3a, 3b, 4a, and 4b exert inhibition by binding to enzyme through only a portion of their structures at any one time. The inhibition exhibited by N-ethyl-1,7-diaminoheptane 20 and its guanyl derivative 21 supports this notion and is evidence for participation of the secondary amino group in binding

  在真核起始因子5A（eIF-5A）中，脱氧酪氨酸合酶催化翻译后形成氨基酸酪氨酸[N epsilon-（4-氨基-2-羟基丁基）赖氨酸]的起始步骤。据信eIF-5A及其乙酰尿素修饰对细胞生长至关重要。合成了许多与二胺和三胺有关的化合物，并测试了该酶的抑制剂。该发现表明，长链三胺2a和2b及其鸟苷衍生物3a，3b，4a和4b通过在任何时候仅通过其结构的一部分与酶结合而发挥抑制作用。N-乙基-1,7-二氨基庚烷20及其鸟苷衍生物21表现出的抑制作用支持了这一观点，并且是仲氨基参与与酶结合的证据。有初步证据表明，mid基和异硫脲鎓基团也可以作为与酶结合的基本中心。在此测试的化合物中，很少有一种能与1-胍基-7-氨基庚烷（GC7）（最有效的脱氧嘧啶合酶抑制剂）相媲美，在抑制中国仓鼠卵巢细胞中的酶方面，几乎没有一种化合物能与GC7媲美。因此，与GC7的抗增殖作用不同，GC7的抗增殖作用有证据证明是干扰
• CYCLIC DINUCLEOTIDES CONTAINING BENZIMIDAZOLE, METHOD FOR THE PRODUCTION OF SAME, AND USE OF SAME TO ACTIVATE STIMULATOR OF INTERFERON GENES (STING)-DEPENDENT SIGNALING PATHWAYS
  申请人：BIOLOG LIFE SCIENCE INSTITUTE FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH

  公开号：US20200040028A1

  公开（公告）日：2020-02-06

  Cyclic dinucleotides are described, which in contrast to their natural congeners carry lipophilic nucleobases and have higher membrane permeability and increased biological activity.

  描述了环状二核苷酸，与它们的天然同源体相比，它们携带亲脂性核碱基，具有更高的膜渗透性和增强的生物活性。
• Fungicidal Mixtres Based On 3-Monosubstituted N-Bipenyl-Pyrazolecarboxamides
  申请人：Dietz Jochen

  公开号：US20090233795A1

  公开（公告）日：2009-09-17

  Fungicidal mixtures comprising, as active components, 1) at least one 3-mono disubstituted N-biphenylpyrazolecarboxamide of the formula I in which X=oxygen or sulfur; R 1 =cyano, nitro, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, methoxy, difluoromethoxy, trifluoromethoxy, methylthio, difluoromethylthio or trifluoromethylthio; R 2 =halogen, C 1 -C 4 -alkyl or C 1 -C 4 -haloalkyl; R 3 =hydrogen or halogen; and 2) at least one active compound II selected from active compound groups A) to F): A) azoles; B) strobilurins; C) carboxamides; D) heterocyclic compounds; E) carbamates; F) other fungicides; in a synergistically effective amount, methods for controlling harmful fungi using mixtures of at least one compound I and at least one active compound II, the use of the compound(s) I with active compounds II for preparing such mixtures and also compositions and seed comprising these mixtures.

  含有杀真菌混合物，其活性成分为1) 至少一种具有以下化学式I的3-单二取代N-联苯基吡唑羧酰胺，其中X=氧或硫；R1=氰基、硝基、卤素、C1-C6-烷基、C1-C6-卤代烷基、甲氧基、二氟甲氧基、三氟甲氧基、甲硫氧基、二氟甲硫基或三氟甲硫基；R2=卤素、C1-C4-烷基或C1-C4-卤代烷基；R3=氢或卤素；以及2) 从活性化合物组A)至F)中选择的至少一种活性化合物II：A) 唑类；B) 叠氮酮；C) 联苯基胺；D) 杂环化合物；E) 氨基甲酸酯；F) 其他杀真菌剂；在协同作用有效量下的方法，使用至少一种化合物I和至少一种活性化合合物II的混合物来控制有害真菌，使用化合物I与活性化合合物II来制备这种混合物，以及包含这些混合物的组合物和种子。