(4S,1'R)-1',7',7'-trimethyl-spiro[imidazolidine-4,2'-norbornane]-2,5-dione | 17138-06-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4S,1'R)-1',7',7'-trimethyl-spiro[imidazolidine-4,2'-norbornane]-2,5-dione
• 英文别名: (4S,1'R)-1',7',7'-Trimethyl-spiro[imidazolidin-4,2'-norbornan]-2,5-dion；(1R,2S,4R)-1,7,7-trimethylspiro[bicyclo[2.2.1]heptane-2,5'-imidazolidine]-2',4'-dione
• CAS: 17138-06-6
• 化学式: C₁₂H₁₈N₂O₂
• 分子量: 222.287
• InChiKey: ZNLWSSZADRGRKU-NZXMKCKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.41
• 重原子数：
  16.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  58.2
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (4S,1'R)-1',7',7'-trimethyl-spiro[imidazolidine-4,2'-norbornane]-2,5-dione 在 sodium hydroxide 作用下， 生成 (1R)-2-amino-1,7,7-trimethyl-norbornane-2exo-carboxylic acid
  参考文献：
  名称：

  Magma evolution in the Purico ignimbrite complex, northern Chile: evidence for zoning of a dacitic magma by injection of rhyolitic melts following mafic recharge

  摘要：

  The 1.3 Ma Purico complex is part of an extensive Neogene-Pleistocene ignimbrite province in the central Andes. Like most other silicic complexes in the province, Purico is dominated by monotonous intermediate ash-flow sheets and has volumetrically minor lava domes. The Purico ignimbrites (total volume 80-100 km(3)) are divided into a Lower Purico Ignimbrite (LPI) with two extensive flow units, LPI I and LPI II; and a smaller Upper Purico Ignimbrite (UPI) unit. Crystal-rich dacite is the dominant lithology in all the Purico ignimbrites and in the lava domes. It is essentially the only lithology present in the first LPI flow unit (LPI I) and in the Upper Purico Ignimbrite, but the LPI II flow unit is unusual for its compositional diversity. It constitutes a stratigraphic sequence with a basal fall-out deposit containing rhyolitic pumice (68-74 wt% SiO2) overlain by ignimbrite with dominant crystal-rich dacitic pumice (64-66 wt% SiO2). Rare andesitic and banded pumice (60-61 wt% SiO2) are also present in the uppermost part of the flow unit. The different compositional groups of pumice in LPI II flow unit (rhyolite, andesite, dacite) have initial Nd and Sr isotopic compositions that are indistinguishable from each other and from the dominant dacitic pumice (epsilon Nd = -6.7 to -7.2 and Sr-87/Sr-86 = 0.7085-0.7090). However, two lines of evidence show that the andesite, dacite and rhyolite pumices do not represent a simple fractionation series. First, melt inclusions trapped in sequential growth zones of zoned plagioclase grains in the rhyolite record fractionation trends in the melt that diverge from those shown by dacite samples. Second, mineral equilibrium geothermometry reveals that dacites from all ignimbrite flow units and from the domes had relatively uniform and moderate pre-eruptive temperatures (780-800 degreesC), whereas the rhyalites and andesites yield consistently higher temperatures (850-950 degreesC). Hornblende geobarometry and pressure constraints from H2O and CO2 contents in melt inclusions indicate upper crustal (4-8 km) magma storage conditions. The petrologic evidence from the LPI II system thus indicates an anomalously zoned magma chamber with a rhyolitic cap that was hotter than, and chemically unrelated to, the underlying dacite. We suggest that the hotter rhyolite and andesite magmas are both related to an episode of replenishment in the dacitic Purico magma chamber. Rapid and effective crystal fractionation of the fresh andesite produced a hot rhyolitic melt whose low density and viscosity permitted ascent through the chamber without significant thermal and chemical equilibration with the resident dacite. Isotopic and compositional variations in the Purico system are typical of those seen throughout the Neogene ignimbrite complexes of the Central Andes. These characteristics were generated at moderate crustal depths (< 30 km) by crustal melting, mixing and homogenization involving mantle-derived basalts. For the Purico system, assimilation of at least 30% mantle-derived material is required.

  DOI：

  10.1007/s004100000214
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 碳酸氢铵 作用下， 生成 camphor-2-spirohydantoin 、 (4S,1'R)-1',7',7'-trimethyl-spiro[imidazolidine-4,2'-norbornane]-2,5-dione
  参考文献：
  名称：

  Magma evolution in the Purico ignimbrite complex, northern Chile: evidence for zoning of a dacitic magma by injection of rhyolitic melts following mafic recharge

  摘要：

  The 1.3 Ma Purico complex is part of an extensive Neogene-Pleistocene ignimbrite province in the central Andes. Like most other silicic complexes in the province, Purico is dominated by monotonous intermediate ash-flow sheets and has volumetrically minor lava domes. The Purico ignimbrites (total volume 80-100 km(3)) are divided into a Lower Purico Ignimbrite (LPI) with two extensive flow units, LPI I and LPI II; and a smaller Upper Purico Ignimbrite (UPI) unit. Crystal-rich dacite is the dominant lithology in all the Purico ignimbrites and in the lava domes. It is essentially the only lithology present in the first LPI flow unit (LPI I) and in the Upper Purico Ignimbrite, but the LPI II flow unit is unusual for its compositional diversity. It constitutes a stratigraphic sequence with a basal fall-out deposit containing rhyolitic pumice (68-74 wt% SiO2) overlain by ignimbrite with dominant crystal-rich dacitic pumice (64-66 wt% SiO2). Rare andesitic and banded pumice (60-61 wt% SiO2) are also present in the uppermost part of the flow unit. The different compositional groups of pumice in LPI II flow unit (rhyolite, andesite, dacite) have initial Nd and Sr isotopic compositions that are indistinguishable from each other and from the dominant dacitic pumice (epsilon Nd = -6.7 to -7.2 and Sr-87/Sr-86 = 0.7085-0.7090). However, two lines of evidence show that the andesite, dacite and rhyolite pumices do not represent a simple fractionation series. First, melt inclusions trapped in sequential growth zones of zoned plagioclase grains in the rhyolite record fractionation trends in the melt that diverge from those shown by dacite samples. Second, mineral equilibrium geothermometry reveals that dacites from all ignimbrite flow units and from the domes had relatively uniform and moderate pre-eruptive temperatures (780-800 degreesC), whereas the rhyalites and andesites yield consistently higher temperatures (850-950 degreesC). Hornblende geobarometry and pressure constraints from H2O and CO2 contents in melt inclusions indicate upper crustal (4-8 km) magma storage conditions. The petrologic evidence from the LPI II system thus indicates an anomalously zoned magma chamber with a rhyolitic cap that was hotter than, and chemically unrelated to, the underlying dacite. We suggest that the hotter rhyolite and andesite magmas are both related to an episode of replenishment in the dacitic Purico magma chamber. Rapid and effective crystal fractionation of the fresh andesite produced a hot rhyolitic melt whose low density and viscosity permitted ascent through the chamber without significant thermal and chemical equilibration with the resident dacite. Isotopic and compositional variations in the Purico system are typical of those seen throughout the Neogene ignimbrite complexes of the Central Andes. These characteristics were generated at moderate crustal depths (< 30 km) by crustal melting, mixing and homogenization involving mantle-derived basalts. For the Purico system, assimilation of at least 30% mantle-derived material is required.

  DOI：

  10.1007/s004100000214

文献信息

• Some terpene and steroid hydantoins
  作者：R. J. W. Cremlyn、Mary Chisholm

  DOI：10.1039/j39670001762

  日期：——

  3β-Hydroxy-5α-androstan-17-one, (+)-camphor, and (–)-menthone have been converted into the corresponding spiro-hydantoins by the Bucherer synthesis. The reaction failed with cholestan-7-one, cholest-4-en-3-one, and 17α,21-dihydroxy-5α-pregnane-3,11,20-tri-one 3,20-disemicarbazone. Efforts to obtain steroid dihydantoins were unsuccessful. Deamination of camphane and menthane amino-acids provides evidence

  通过Bucherer合成，将3β-Hydroxy-5α-androstan-17-one，（+）-樟脑和（-）-薄荷酮转化为相应的螺乙内酰脲。反应失败的是胆甾烷7-1，胆甾烯4-en-3-one和17α，21-二羟基-5α-孕烯-3,11,20-三酮3,20-双半碳zone。获得类固醇二乙内酰脲的努力未成功。樟脑和薄荷烷氨基酸的脱氨基提供了其构型的证据。