α-aminohexanephosphonic acid | 63207-60-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: α-aminohexanephosphonic acid
• 英文别名: (1-amino-hexyl)-phosphonic acid；1-Aminohexanphosphonsaeure；1-Ammonium-hexane-1-phosphonic acid anion；1-azaniumylhexyl(hydroxy)phosphinate
• CAS: 63207-60-3
• 化学式: C₆H₁₆NO₃P
• 分子量: 181.172
• InChiKey: ODMTWOKJHVPSLP-UHFFFAOYSA-N

物化性质

• 熔点：
  270-276 °C(lit.)
• 沸点：
  333.7±44.0 °C(Predicted)
• 密度：
  1.201±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• 海关编码：
  2931900090
• 安全说明：
  S26,S36

SDS

Name:	(1-Aminohexyl)phosphonic acid 97% Material Safety Data Sheet
Synonym:	None Known
CAS:	63207-60-3

Section 1 - Chemical Product MSDS Name:(1-Aminohexyl)phosphonic acid 97% Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
63207-60-3	(1-Aminohexyl)phosphonic acid	97%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 63207-60-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 265 - 268 deg C (de
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: C6H16NO3P
Molecular Weight: 181.17

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable. Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of phosphorus, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 63207-60-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
(1-Aminohexyl)phosphonic acid - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 63207-60-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 63207-60-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 63207-60-3 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为产物：
  描述：

  hexanoyl-phosphonic acid diethyl ester 在 盐酸 、 锌 作用下， 以 溶剂黄146 、 三氟乙酸 为溶剂， 反应 11.0h， 生成 α-aminohexanephosphonic acid
  参考文献：
  名称：

  Synthesis ofO,O-Dialkyl 1-Aminoalkanephosphonates

  摘要：

  DOI：

  10.1055/s-1980-29311

文献信息

• METHOD OF PRODUCING EPOXY COMPOUNDS
  申请人：Uchida Hiroshi

  公开号：US20110263882A1

  公开（公告）日：2011-10-27

  Provided is a method of efficiently producing an epoxy compound from an allyl ether having an aromatic ring under mild conditions by using hydrogen peroxide as an oxidizing agent without using an organic solvent. The method of producing an epoxy compound comprises reacting an allyl ether having an aromatic ring with hydrogen peroxide to epoxidize a carbon-carbon double bond of an allyl group to thereby produce a corresponding epoxy compound having an aromatic ring, wherein water only is used as a solvent without using an organic solvent, and a tungsten compound, and a tertiary amine and/or a quaternary ammonium salt, are used as a reaction catalyst.

  提供了一种在温和条件下使用过氧化氢作为氧化剂，而无需使用有机溶剂，从具有芳香环的烯丙基醚高效生产环氧化合物的方法。生产环氧化合物的方法包括将具有芳香环的烯丙基醚与过氧化氢反应，使烯丙基团的碳-碳双键环氧化，从而产生具有芳香环的相应环氧化合物，其中仅使用水作为溶剂，不使用有机溶剂，并且使用钨化合物、三级胺和/或季铵盐作为反应催化剂。
• Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20030105111A1

  公开（公告）日：2003-06-05

  The present invention is directed to a compound of Formula I: 1 wherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

  本发明涉及一种具有以下结构的化合物：其中A、R1和R2在此处被定义。本发明还涉及包含Formula I化合物的组合物、使用Formula I化合物的方法以及制备Formula I化合物的方法。
• Fluorescent nucleotide analogs and uses therefor
  申请人：Xu Yue

  公开号：US20070072196A1

  公开（公告）日：2007-03-29

  Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.

  在模板定向的核酸合成反应和其他核酸反应以及基于此的各种分析中，使用标记核苷酸模拟物代替自然存在的核苷三磷酸或其他类似物，包括DNA测序、单碱基识别、杂交检测等。
• EPOXIDIZED LOW-MOLECULAR-WEIGHT ETHYLENE POLYMER, MOLD-RELEASING AGENT FOR ELECTROPHOTOGRAPHIC TONER, AND ELECTROPHOTOGRAPHIC TONER FOR DEVELOPING ELECTROSTATIC IMAGE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1707579A1

  公开（公告）日：2006-10-04

  [PROBLEMS] The present invention provides a modifier for an electrophotographic toner which is excellent in adhesiveness with various inks, coating materials, aluminum or other metals, or the like, a release agent of the electrophotographic toner, and a modified electrophotographic toner. [MEANS FOR SOLVING PROBLEMS] A release agent for an electrophotographic toner, which comprises an epoxidized low-molecular-weight ethylene polymer (B) which contains an epoxy group in the polymer chain of a low-molecular-weight ethylene polymer (A), and has (i) a density of 870 to 1,050 kg/m3, (ii) a melting point of 70 to 130°C, and (iii) a number-average molecular weight (Mn) of 400 to 5,000, and a modified low-molecular-weight ethylene compound (C) obtained from the epoxidized low-molecular-weight ethylene polymer (B) and a carboxylic acid compound; and an electrophotographic toner for developing an electrostatic charge image, which comprises the modified low-molecular-weight ethylene compound (C).

  [问题]本发明提供了一种与各种油墨、涂层材料、铝或其他金属等粘合性极佳的电子照相调色剂的改性剂，一种电子照相调色剂的脱模剂，以及一种改性电子照相调色剂。 [解决问题的方法] 一种用于电子照相调色剂的脱模剂，它包括环氧化低分子量乙烯聚合物 (B)，该聚合物在低分子量乙烯聚合物 (A) 的聚合物链中含有环氧基团，并且 (i) 密度为 870 至 1、050 kg/m3，(ii) 熔点为 70 至 130°C，(iii) 数均分子量 (Mn) 为 400 至 5000，以及由环氧化低分子量乙烯聚合物 (B) 和羧酸化合物制得的改性低分子量乙烯化合物 (C)；以及用于显影静电荷图像的电子照相调色剂，其中包含改性低分子量乙烯化合物 (C)。
• PROCESS FOR PRODUCTION OF EPOXY COMPOUND
  申请人：Showa Denko K.K.

  公开号：EP2261219A1

  公开（公告）日：2010-12-15

  A novel process for producing a polyfunctional epoxy monomer is provided that facilitates separation of an aqueous layer catalyst from a reaction solution and has satisfactory hydrogen peroxide efficiency by reacting an aqueous hydrogen peroxide solution with a polyolefin without using an organic solvent and under mild conditions. The process as claimed in the present invention is a process for producing a corresponding epoxy compound by reacting an organic compound having a carbon-carbon double bond with hydrogen peroxide present in an aqueous hydrogen peroxide solution to epoxidate the double bond, wherein a tungsten compound and tertiary amine are used as reaction catalysts.

  本发明提供了一种生产多官能团环氧单体的新工艺，该工艺通过过氧化氢水溶液与聚烯烃在不使用有机溶剂和温和的条件下进行反应，便于从反应溶液中分离水层催化剂，并具有令人满意的过氧化氢效率。 本发明所述的工艺是通过使具有碳碳双键的有机化合物与存在于过氧化氢水溶液中的过氧化氢反应，使双键环氧化，从而生产相应的环氧化合物的工艺，其中使用钨化合物和叔胺作为反应催化剂。