1,4-bis(aminomethyl)naphthalene | 108629-58-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,4-bis(aminomethyl)naphthalene
• 英文别名: 1,4-Di-(aminomethyl)-naphthalin；1,4-Bis-aminomethyl-naphthalin；1,4-Di-aminomethyl-naphthalin；[4-(Aminomethyl)naphthalen-1-yl]methanamine
• CAS: 108629-58-9
• 化学式: C₁₂H₁₄N₂
• mdl: MFCD06213867
• 分子量: 186.257
• InChiKey: BVYVWIWVKIKNOU-UHFFFAOYSA-N

物化性质

• 熔点：
  51-52 °C(Solv: ligroine (8032-32-4))
• 沸点：
  158-165 °C(Press: 0.3 Torr)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-bis(aminomethyl)naphthalene 在 lithium hydroxide 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 121.0h， 生成
  参考文献：
  名称：

  Generation and in Situ Evaluation of Libraries of Poly(acrylic acid) Presenting Sialosides as Side Chains as Polyvalent Inhibitors of Influenza-Mediated Hemagglutination

  摘要：

  This paper describes a simple, microscale method for generating and evaluating libraries of derivatives of poly(acrylic acid) (pAA) that present mixtures of side chains that influence their biological activity. The method is based on the one-step conversion of poly(acrylic anhydride) (pAAn) to linear polymers presenting multiple units of R on side chains, pAA(R): the polymers are obtained by ultrasonication of a suspension of pAAn and aqueous RNH2 contained in a 250-mu L well of a microtiter plate. Using this method, derivatives of pAA having N-acetylneuraminic acid (NeuAc-L-NH2) as a side chain, pAA(NeuAc-L), were generated and assayed for ability to inhibit hemagglutination (HAI) of chicken erythrocytes by influenza virus A (X-31); the constant (KHAT) describing this inhibition is calculated on the basis of the concentration of NeuAc groups in solution, rather than the concentration of polymer molecules. Go-polymeric pAA(NeuAc-L-n; L-n=different linking groups) with a range of mole fractions of NeuAc-L-NH2 (chi(NeuAc-L)=0.02-0.11) exhibited HAI activities with K-i(HAI) values between 27 and 0.30 mu M. Using combinations of NeuAc-L-NH2 and one of 26 different primary amines RNH2, a variety of ter-polymeric pAA(NeuAc-L; R) (chi(Neu-Ac-L)similar to 0.05; chi(R) similar to 0.06) were also generated and assayed. Certain ter-polymers yielded values of K-i(HAI) that were lower by a factor of similar to 10(4) than that of the parent co-polymeric pAA(NeuAc-L): the most active inhibitor was pAA(NeuAc-L; L-3-(2'-naphthyl)alanine)) (K(i)(HAI)approximate to 0.05 mM). Typically, the incorporation of hydrophobic-especially aromatic-side chains enhanced activities. These polymers (pAA(NeuAc-L; R)) belong to a new class of polymeric, polyvalent sialosides that are potent inhibitors of the adsorption of influenza virus to erythrocytes. They were active with only low to moderate levels of incorporation of functional groups into the side chains: chi(NeuAc-L)similar to 0.05; chi(R) similar to 0.06.

  DOI：

  10.1021/ja963519x
• 作为产物：
  描述：

  1,4-双(溴甲基)萘 在 palladium on activated charcoal sodium azide 、 氢气 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 生成 1,4-bis(aminomethyl)naphthalene
  参考文献：
  名称：

  Generation and in Situ Evaluation of Libraries of Poly(acrylic acid) Presenting Sialosides as Side Chains as Polyvalent Inhibitors of Influenza-Mediated Hemagglutination

  摘要：

  This paper describes a simple, microscale method for generating and evaluating libraries of derivatives of poly(acrylic acid) (pAA) that present mixtures of side chains that influence their biological activity. The method is based on the one-step conversion of poly(acrylic anhydride) (pAAn) to linear polymers presenting multiple units of R on side chains, pAA(R): the polymers are obtained by ultrasonication of a suspension of pAAn and aqueous RNH2 contained in a 250-mu L well of a microtiter plate. Using this method, derivatives of pAA having N-acetylneuraminic acid (NeuAc-L-NH2) as a side chain, pAA(NeuAc-L), were generated and assayed for ability to inhibit hemagglutination (HAI) of chicken erythrocytes by influenza virus A (X-31); the constant (KHAT) describing this inhibition is calculated on the basis of the concentration of NeuAc groups in solution, rather than the concentration of polymer molecules. Go-polymeric pAA(NeuAc-L-n; L-n=different linking groups) with a range of mole fractions of NeuAc-L-NH2 (chi(NeuAc-L)=0.02-0.11) exhibited HAI activities with K-i(HAI) values between 27 and 0.30 mu M. Using combinations of NeuAc-L-NH2 and one of 26 different primary amines RNH2, a variety of ter-polymeric pAA(NeuAc-L; R) (chi(Neu-Ac-L)similar to 0.05; chi(R) similar to 0.06) were also generated and assayed. Certain ter-polymers yielded values of K-i(HAI) that were lower by a factor of similar to 10(4) than that of the parent co-polymeric pAA(NeuAc-L): the most active inhibitor was pAA(NeuAc-L; L-3-(2'-naphthyl)alanine)) (K(i)(HAI)approximate to 0.05 mM). Typically, the incorporation of hydrophobic-especially aromatic-side chains enhanced activities. These polymers (pAA(NeuAc-L; R)) belong to a new class of polymeric, polyvalent sialosides that are potent inhibitors of the adsorption of influenza virus to erythrocytes. They were active with only low to moderate levels of incorporation of functional groups into the side chains: chi(NeuAc-L)similar to 0.05; chi(R) similar to 0.06.

  DOI：

  10.1021/ja963519x

文献信息

• NOVEL MONOMERS FROM BIOMASS
  申请人：SIBI Mukund P.

  公开号：US20170233325A1

  公开（公告）日：2017-08-17

  Compounds derived from biomass, e.g., cellulose and lignins, methods of forming such compounds and polymers and products formed using such compounds.

  从生物质中提取的化合物，例如纤维素和木质素，以及形成这些化合物和聚合物以及使用这些化合物形成的产品的方法。
• CURABLE EPOXY RESIN COMPOSITION
  申请人：ASAHI DENKA KOGYO KABUSHIKI KAISHA

  公开号：EP0870790A1

  公开（公告）日：1998-10-14

  Curable epoxy resin composition comprising (a) epoxy resin (A), (b) curing agent (B) for the epoxy resin, selected from the group consisting of amine compound (B-1) and its denatured products (B-2) and polythiol compound (B-3), (c) absorbent or adsorbent (C), and optionally (d) catalyst (D) for accelerating a reaction between epoxy group and mercapto group, which is used optionally when the amine compound (B-1) and its denatured products (B-2) is not used as the curing agent (B). The composition can contain absorbent or adsorbent (C) a proportion of 10 to 200 parts by weight with respect to 100 parts by weight of the epoxy resin (A) to produce absorptive-adsorptive cured article.

  可固化环氧树脂组合物，包括(a)环氧树脂(A)，(b)环氧树脂固化剂(B)，选自由胺化合物(B-1)及其变性产物(B-2)和聚硫醇化合物(B-3)组成的组、(c) 吸收剂或吸附剂 (C)，以及 (d) 催化剂 (D)，用于加速环氧基团和巯基之间的反应，当胺化合物 (B-1) 及其变性产物 (B-2) 不用作固化剂 (B) 时，可选择使用催化剂 (D)。相对于 100 重量份的环氧树脂（A），该组合物可含有 10 至 200 重量份的吸收剂或吸附剂 （C），以生产吸收-吸附固化物。
• CURABLE EPOXY RESIN COMPOSITION WHICH GIVES FLEXIBLE CURED ARTICLE
  申请人：ASAHI DENKA KOGYO KABUSHIKI KAISHA

  公开号：EP0872504A1

  公开（公告）日：1998-10-21

  A curable epoxy resin composition for producing hardened product having flexibility,.comprising (a) epoxy resin (A), (b) monothiol compound (B) having one mercapto group, (c) curing agent (C) for the epoxy resin, selected from the group consisting of of amine compound (C-1) and its denatured products (C-2) and polythiol compound (C-3), and optionally (d) catalyst (D) for accelerating a reaction between epoxy group and mercapto group, which is used optionally when the amine compound (C-1) or its denatured products (C-2) is not used as the curing agent (C).

  一种用于生产具有柔韧性的硬化产品的可固化环氧树脂组合物。包括 (a) 环氧树脂 (A)；(b) 具有一个巯基的单硫醇化合物 (B)；(c) 环氧树脂固化剂 (C)，选自胺化合物 (C-1) 及其变性产物 (C-2) 和聚硫醇化合物 (C-3) 组成的组、以及 (d) 催化剂 (D)，用于加速环氧基团和巯基之间的反应，当胺化合物 (C-1) 或其变性产物 (C-2) 不用作固化剂 (C) 时，可选择使用催化剂 (D)。
• POLYAMIDE RESIN COMPOSITION
  申请人：UBE Industries, Ltd.

  公开号：EP3412731A1

  公开（公告）日：2018-12-12

  Provided is a polyamide resin composition which comprises a polyamide resin (A) and an impact-resistant material (B), wherein the polyamide resin (A) comprises an aliphatic copolyamide (A-1) comprising three or more types of monomers and an aliphatic polyamide (A-2), wherein the content of the aliphatic copolyamide (A-1) in the polyamide resin composition is 1% by mas to 30% by mass.

  本发明提供了一种聚酰胺树脂组合物，它由聚酰胺树脂（A）和抗冲击材料（B）组成，其中聚酰胺树脂（A）包括由三种或三种以上单体组成的脂肪族共聚多酰胺（A-1）和脂肪族聚酰胺（A-2），脂肪族共聚多酰胺（A-1）在聚酰胺树脂组合物中的含量为 1%（质量分数）至 30%（质量分数）。
• MULTILAYER TUBE
  申请人：UBE Industries, Ltd.

  公开号：EP3437850A1

  公开（公告）日：2019-02-06

  A multilayer tube is provided which includes a layer including a specific aliphatic polyamide composition and a layer including a semi-aromatic polyamide composition including a semi-aromatic polyamide with a specific structure, these layers being adjacent to each other, wherein the aliphatic polyamide composition includes an aliphatic polyamide having a specific ratio of the number of methylene groups to the number of amide groups, a polyamide having a specific difference in absolute value of solubility parameter SP from the aliphatic polyamide, and an elastomer polymer including a structural unit derived from an unsaturated compound having a carboxyl group and/or an acid anhydride group.

  本发明提供了一种多层管，其中包括一层脂肪族聚酰胺组合物和一层半芳香族聚酰胺组合物，半芳香族聚酰胺组合物包括具有特定结构的半芳香族聚酰胺，这些层彼此相邻、其中脂肪族聚酰胺组合物包括具有亚甲基数与酰胺基数的特定比率的脂肪族聚酰胺、与脂肪族聚酰胺的溶解度参数SP的绝对值有特定差异的聚酰胺，以及弹性体聚合物，其中弹性体聚合物包括从具有羧基和/或酸酐基的不饱和化合物衍生的结构单元。