2,4-bis-acetylamino-benzaldehyde | 25199-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-bis-acetylamino-benzaldehyde
• 英文别名: 2,4-Bis-acetylamino-benzaldehyd；2.4-Bis-acetamino-benzaldehyd；N-(5-acetamido-2-formylphenyl)acetamide；N-(3-acetamido-4-formylphenyl)acetamide
• CAS: 25199-25-1
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.228
• InChiKey: LQXSPVUIIJUBIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-bis-acetylamino-benzaldehyde 生成 2,4-bis-acetylamino-benzaldehyde phenylhydrazone
  参考文献：
  名称：

  THE PREPARATION OF o- AND p-ACETAMINOBENZALDEHYDES

  摘要：

  N,N-二乙酰-o-甲苯胺经N-溴代琥珀酰亚胺处理，随后水解中间二溴化合物，得到o-乙酰氨基苯甲醛。该反应成功应用于N,N-二乙酰-p-甲苯胺，N,N-二乙酰-4-氯-o-甲苯胺，2,4-双(二乙酰氨基)甲苯和4-乙酰氧基-N,N-二乙酰-o-甲苯胺。

  DOI：

  10.1139/v55-226
• 作为产物：
  描述：

  2,4-二乙酰基氨基甲苯 在 四氯化碳 、 N-溴代丁二酰亚胺(NBS) 作用下， 生成 2,4-bis-acetylamino-benzaldehyde
  参考文献：
  名称：

  THE PREPARATION OF o- AND p-ACETAMINOBENZALDEHYDES

  摘要：

  N,N-二乙酰-o-甲苯胺经N-溴代琥珀酰亚胺处理，随后水解中间二溴化合物，得到o-乙酰氨基苯甲醛。该反应成功应用于N,N-二乙酰-p-甲苯胺，N,N-二乙酰-4-氯-o-甲苯胺，2,4-双(二乙酰氨基)甲苯和4-乙酰氧基-N,N-二乙酰-o-甲苯胺。

  DOI：

  10.1139/v55-226

文献信息

• USE OF PIPERIDINE DERIVATIVES FOR PROMOTING ANGIOGENESIS
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1708705B1

  公开（公告）日：2009-02-18
• PHARMACEUTICAL COMPOSITION FOR PROMOTING ANGIOGENESIS
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1708705A1

  公开（公告）日：2006-10-11
• Pharmaceutical composition for promoting angiogenesis
  申请人：Hashimoto Ayako

  公开号：US20090187025A1

  公开（公告）日：2009-07-23

  The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R 1 represents a hydrogen atom or a lower alkyl group; and R 2 represents a phenyl lower alkyl group).
• US8445516B2
  申请人：——

  公开号：US8445516B2

  公开（公告）日：2013-05-21
• [EN] PHARMACEUTICAL COMPOSITION FOR PROMOTING ANGIOGENESIS<br/>[FR] COMPOSITION PHARMACEUTIQUE FAVORISANT L'ANGIOGENESE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005072734A1

  公开（公告）日：2005-08-11

  The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R1 represents a hydrogen atom or a lower alkyl group; and R2 represents a phenyl lower alkyl group).