tert-butyl N-[1-(4-methylbenzoyl)piperidin-4-yl]carbamate | 1310458-31-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[1-(4-methylbenzoyl)piperidin-4-yl]carbamate
• CAS: 1310458-31-1
• 化学式: C₁₈H₂₆N₂O₃
• 分子量: 318.416
• InChiKey: OTXJQERKXQYTID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[1-(4-methylbenzoyl)piperidin-4-yl]carbamate 在 三氟乙酸 、 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 生成 (4-Amino-1-piperidinyl)(4-methylphenyl)methanone
  参考文献：
  名称：

  Discovery of novel isopropanolamine inhibitors against MoTPS1 as potential fungicides with unique mechanisms

  摘要：

  DOI：

  10.1016/j.ejmech.2023.115755
• 作为产物：
  描述：

  对甲基苯甲酰氯 、 4-叔丁氧羰基氨基哌啶 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以92%的产率得到tert-butyl N-[1-(4-methylbenzoyl)piperidin-4-yl]carbamate
  参考文献：
  名称：

  The (1-methyl)cyclopropyloxycarbonyl (MPoc) carbamate: a new protecting group for amines

  摘要：

  The (1-methyl)cyclopropyl carbamate (MPoc) group represents a new and useful protecting group for amines. It adds relatively little molecular weight and has a simple (1)H NMR spectrum. It is orthogonal to the commonly used BOC, Cbz, Alloc, and FMOC groups. MPoc protected amines are resistant to extremes of pH, amines, halogens, many oxidizing agents, and to hydrogenation at ambient temperature. The MPoc group is cleaved by exposure to hypobromous acid or upon hydrogenolysis over palladium at 80 degrees C. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.027

文献信息

• The (1-methyl)cyclopropyloxycarbonyl (MPoc) carbamate: a new protecting group for amines
  作者：Erik J. Snider、Stephen W. Wright

  DOI：10.1016/j.tetlet.2011.04.027

  日期：2011.6

  The (1-methyl)cyclopropyl carbamate (MPoc) group represents a new and useful protecting group for amines. It adds relatively little molecular weight and has a simple (1)H NMR spectrum. It is orthogonal to the commonly used BOC, Cbz, Alloc, and FMOC groups. MPoc protected amines are resistant to extremes of pH, amines, halogens, many oxidizing agents, and to hydrogenation at ambient temperature. The MPoc group is cleaved by exposure to hypobromous acid or upon hydrogenolysis over palladium at 80 degrees C. (C) 2011 Elsevier Ltd. All rights reserved.
• [EN] NAMPT MODULATORS<br/>[FR] MODULATEURS DE NAMPT
  申请人：CYTOKINETICS INC

  公开号：WO2021226276A2

  公开（公告）日：2021-11-11

  Provided are compounds of Formula (II): or a pharmaceutically acceptable salt thereof, wherein R1, n, and Y1 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.
• Discovery of novel isopropanolamine inhibitors against MoTPS1 as potential fungicides with unique mechanisms
  作者：Zhiyang Jiang、Dongmei Shi、Yitong Chen、Huilin Li、Jin'e Wang、Xinrui Lv、Yunjiang Zi、Dongli Wang、Zhijian Xu、Jiaxing Huang、Junfeng Liu、Hongxia Duan

  DOI：10.1016/j.ejmech.2023.115755

  日期：2023.11