4-[2-[Tert-butyl-bis(4-methylphenyl)silyl]oxyethyl]phenol | 1394170-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-[2-[Tert-butyl-bis(4-methylphenyl)silyl]oxyethyl]phenol
• 英文别名: 4-[2-[tert-butyl-bis(4-methylphenyl)silyl]oxyethyl]phenol
• CAS: 1394170-53-6
• 化学式: C₂₆H₃₂O₂Si
• 分子量: 404.624
• InChiKey: XHEOMUVGKSGDRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.13
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  六氟异丙醇 、 4-[2-[Tert-butyl-bis(4-methylphenyl)silyl]oxyethyl]phenol 在 碘苯二乙酸 作用下， 反应 0.02h， 以51%的产率得到1-(2-((tert-butyl((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)(p-tolyl)silyl)oxy)ethyl)-4'-methyl-[1,1'-biphenyl]-4(1H)-one
  参考文献：
  名称：

  Oxidative ipso-Rearrangement Performed by a Hypervalent Iodine Reagent and Its Application

  摘要：

  An oxidative ipso-rearrangement mediated by a hypervalent iodine reagent that enables rapid generation of a functionalized dienone system containing a quaternary carbon center connected to several sp(2) centers has been developed. The process occurs through transfer of an aryl group from a silyl segment present on the lateral chain. As an illustration of the potential of this transformation, a total synthesis of sceletenone, a small alkaloid, is described.

  DOI：

  10.1021/jo301408j
• 作为产物：
  描述：

  2-(4{[tert-butyl(dimethyl)silyl]oxy}phenyl)ethanol 在 咪唑 、 甲醇 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-[2-[Tert-butyl-bis(4-methylphenyl)silyl]oxyethyl]phenol
  参考文献：
  名称：

  Oxidative ipso-Rearrangement Performed by a Hypervalent Iodine Reagent and Its Application

  摘要：

  An oxidative ipso-rearrangement mediated by a hypervalent iodine reagent that enables rapid generation of a functionalized dienone system containing a quaternary carbon center connected to several sp(2) centers has been developed. The process occurs through transfer of an aryl group from a silyl segment present on the lateral chain. As an illustration of the potential of this transformation, a total synthesis of sceletenone, a small alkaloid, is described.

  DOI：

  10.1021/jo301408j

文献信息

• Oxidative <i>ipso</i>-Rearrangement Performed by a Hypervalent Iodine Reagent and Its Application
  作者：Guillaume Jacquemot、Sylvain Canesi

  DOI：10.1021/jo301408j

  日期：2012.9.7

  An oxidative ipso-rearrangement mediated by a hypervalent iodine reagent that enables rapid generation of a functionalized dienone system containing a quaternary carbon center connected to several sp(2) centers has been developed. The process occurs through transfer of an aryl group from a silyl segment present on the lateral chain. As an illustration of the potential of this transformation, a total synthesis of sceletenone, a small alkaloid, is described.