5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid) | 905267-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid)
• 英文别名: 5-[2-[3-Carboxy-4-[2-(2-methoxyethoxy)ethoxy]phenyl]ethynyl]-2-[2-(2-methoxyethoxy)ethoxy]benzoic acid；5-[2-[3-carboxy-4-[2-(2-methoxyethoxy)ethoxy]phenyl]ethynyl]-2-[2-(2-methoxyethoxy)ethoxy]benzoic acid
• CAS: 905267-24-5
• 化学式: C₂₆H₃₀O₁₀
• 分子量: 502.518
• InChiKey: CPSAAVIUAIOLDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  36
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N-(5-amino-2,4-dimethoxyphenyl)-4-(2-(2-methoxyethoxy)ethoxy)nicotinic acid 、 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid) 在 4-二甲氨基吡啶 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以86%的产率得到N-(5-(5-((3-(2,4-dimethoxy-5-(4-(2-(2-methoxyethoxy)ethoxy)nicotinamido)phenylcarbamoyl)-4-(2-(2-methoxyethoxy)ethoxy)phenyl)ethynyl)-2-(2-(2-methoxyethoxy)ethoxy)benzamido)-2,4-dimethoxyphenyl)-N-(2-(2-methoxyethoxy)ethoxy)nicotinamide
  参考文献：
  名称：

  ‘Two-point’-bound supramolecular complexes from semi-rigidified dipyridine receptors and zinc porphyrins

  摘要：

  Two linear compounds 1 and 2 have been designed and synthesized as new receptors for zinc porphyrins. Both compounds consist of two folded aromatic amide moieties, which are connected with an acetylene linker in 1 or directly in 2. The rigid conformations of their folded moieties are stabilized by intramolecular tri-centered hydrogen bonding, while the whole molecule adopts a 'S'- or 'C'-styled conformation depending on the relative orientation of the two rigid moieties. Two pyridine units are introduced at the ends of I and 2 for the complexation of zinc porphyrin guests. Although the H-1 NMR investigation indicated that both compounds can bind two zinc porphyrin guests at high concentrations (>= 5 mM) in chloroform, the UV-vis studies revealed that, at low concentration of 1 and 2 (4 mu M), both compounds complex one zinc porphyrin guest to form structurally unique 'two-point'-bound 1: 1 complexes. The association constants of the 1: 1 complexes have been determined with the UV-vis titration experiments. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.04.082
• 作为产物：
  描述：

  methyl 5-iodo-2-(2-(2-methoxyethoxy)ethoxy)benzoate 在 四(三苯基膦)钯 哌啶 、 sodium hydroxide 、 copper(l) iodide 作用下， 以 甲醇 、 水 为溶剂， 反应 4.33h， 生成 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid)
  参考文献：
  名称：

  ‘Two-point’-bound supramolecular complexes from semi-rigidified dipyridine receptors and zinc porphyrins

  摘要：

  Two linear compounds 1 and 2 have been designed and synthesized as new receptors for zinc porphyrins. Both compounds consist of two folded aromatic amide moieties, which are connected with an acetylene linker in 1 or directly in 2. The rigid conformations of their folded moieties are stabilized by intramolecular tri-centered hydrogen bonding, while the whole molecule adopts a 'S'- or 'C'-styled conformation depending on the relative orientation of the two rigid moieties. Two pyridine units are introduced at the ends of I and 2 for the complexation of zinc porphyrin guests. Although the H-1 NMR investigation indicated that both compounds can bind two zinc porphyrin guests at high concentrations (>= 5 mM) in chloroform, the UV-vis studies revealed that, at low concentration of 1 and 2 (4 mu M), both compounds complex one zinc porphyrin guest to form structurally unique 'two-point'-bound 1: 1 complexes. The association constants of the 1: 1 complexes have been determined with the UV-vis titration experiments. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.04.082

文献信息

• ‘Two-point’-bound supramolecular complexes from semi-rigidified dipyridine receptors and zinc porphyrins
  作者：Chang-Zhi Li、Jiang Zhu、Zong-Quan Wu、Jun-Li Hou、Chuang Li、Xue-Bin Shao、Xi-Kui Jiang、Zhan-Ting Li、Xiang Gao、Quan-Rui Wang

  DOI：10.1016/j.tet.2006.04.082

  日期：2006.7

  Two linear compounds 1 and 2 have been designed and synthesized as new receptors for zinc porphyrins. Both compounds consist of two folded aromatic amide moieties, which are connected with an acetylene linker in 1 or directly in 2. The rigid conformations of their folded moieties are stabilized by intramolecular tri-centered hydrogen bonding, while the whole molecule adopts a 'S'- or 'C'-styled conformation depending on the relative orientation of the two rigid moieties. Two pyridine units are introduced at the ends of I and 2 for the complexation of zinc porphyrin guests. Although the H-1 NMR investigation indicated that both compounds can bind two zinc porphyrin guests at high concentrations (>= 5 mM) in chloroform, the UV-vis studies revealed that, at low concentration of 1 and 2 (4 mu M), both compounds complex one zinc porphyrin guest to form structurally unique 'two-point'-bound 1: 1 complexes. The association constants of the 1: 1 complexes have been determined with the UV-vis titration experiments. (c) 2006 Elsevier Ltd. All rights reserved.