N,N-二乙基-3-(3-苯基丙氧基)丙烷-1-胺 | 27078-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N,N-二乙基-3-(3-苯基丙氧基)丙烷-1-胺
• 英文名称: 3-(diethylamino)propyl 3-phenylpropyl ether
• 英文别名: 3-phenylpropyl 3-(N,N-diethylamino)propyl ether；N,N-Diethyl-3-(3-phenylpropoxy)propylamine；N,N-diethyl-3-(3-phenylpropoxy)propan-1-amine
• CAS: 27078-39-3
• 化学式: C₁₆H₂₇NO
• 分子量: 249.396
• InChiKey: GHSSEDHQUJRUBD-UHFFFAOYSA-N

物化性质

• 沸点：
  340.1±35.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为产物：
  描述：

  Natrium-(3-phenyl-propylat) 、 3-氯-1-二乙氨基丙烷 生成 N,N-二乙基-3-(3-苯基丙氧基)丙烷-1-胺
  参考文献：
  名称：

  Maillard,J. et al., Chimica Therapeutica, 1970, vol. 5, p. 1 - 9

  摘要：

  DOI：

文献信息

• Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
  申请人：——

  公开号：US20040220225A1

  公开（公告）日：2004-11-04

  Use of a compound of formula (A), wherein: 1 W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用式(A)的化合物，其中：1W是一个残基，当附加在咪唑环的4(5)位时，赋予组合物在组胺H3受体上的拮抗和/或激动活性；R1和R2可以相同也可以不同，分别独立地表示较低的烷基或环烷基，或者与它们所连接的氮原子一起，表示饱和的含氮环(i)、非芳香性不饱和含氮环(ii)、吗啡环或N-取代哌嗪环，用于制备在组胺H3受体上作为拮抗剂和/或激动剂的药物。
• Non-imidazole alkylamines as histamine H3- receptor ligands and their therapeutic applications
  申请人：Schwartz Jean-Charles

  公开号：US20060247223A1

  公开（公告）日：2006-11-02

  Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用公式（A）中的化合物，其中： W是一个残留物，当附加到咪唑环的4（5）位时，赋予组织胺H3受体的拮抗和/或激动活性； R1和R2可以相同也可以不同，并且独立地表示较低的烷基或环烷基，或者与它们附着的氮原子一起，表示饱和的含氮环（i）如定义，非芳香性不饱和含氮环（ii）如定义，吗啉基或N-取代的哌嗪基，如定义，用于制备作为组织胺H3受体的拮抗剂和/或激动剂的药物。
• NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：SCHWARTZ Jean-Charles

  公开号：US20110281844A1

  公开（公告）日：2011-11-17

  Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用公式（A）中的化合物，其中： W是一个残基，当连接到咪唑环的4（5）位置时，赋予组合物在组胺H3受体上的拮抗和/或激动活性；R1和R2可能相同也可能不同，且分别独立地代表较低的烷基或环烷基，或者与它们连接的氮原子一起，代表饱和的含氮环（i），如所定义，非芳香性不饱和含氮环（ii），如所定义，吗啡啶基团，或所定义的N-取代哌嗪基团，以制备在组胺H3受体上作为拮抗剂和/或激动剂的药物。
• Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications
  申请人：BIOPROJET

  公开号：EP1428820A1

  公开（公告）日：2004-06-16

  The present invention provides new non-imidazole alkylamine derivatives, and their use for preparing medicaments acting as antagonists and/or agonists at the H3-receptors of histamine.

  本发明提供了新的非咪唑烷基胺衍生物，以及它们在制备用作组胺 H3 受体拮抗剂和/或激动剂的药物中的用途。
• Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands
  申请人：BIOPROJET

  公开号：EP1707203A1

  公开（公告）日：2006-10-04

  The present invention provides new method of treatment of Parkinson's disease, obstructive sleep apnea, dementia with Lewy bodies, vascular dementia with non-imidazole alkylamine derivatives that constitute antagonists of the H3-receptors of histamine.

  本发明提供了用构成组胺 H3 受体拮抗剂的非咪唑类烷基胺衍生物治疗帕金森病、阻塞性睡眠呼吸暂停、路易体痴呆、血管性痴呆的新方法。