氢溴化N-(2-溴乙基)苯胺 | 1005-66-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 氢溴化N-(2-溴乙基)苯胺
• 中文别名: N-(2-溴乙基)苯胺氢溴酸盐
• 英文名称: N-(β-bromoethyl)aniline hydrobromide
• 英文别名: N-(2-Brom-aethyl)-anilin; Hydrobromid；N-<2-Brom-aethyl>-anilid；N-(2-bromo-ethyl)-aniline; hydrobromide；N-(2-bromoethyl)anilinium bromide；N-(2-Bromoethyl)aniline hydrobromide；N-(2-bromoethyl)aniline;hydrobromide
• CAS: 1005-66-9
• 化学式: BrH*C₈H₁₀BrN
• 分子量: 280.99
• InChiKey: MXNALQRSXHOIEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.72
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  16.6
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  氢溴化N-(2-溴乙基)苯胺 在 硫化氢 作用下， 生成 2-(苯基氨基)-乙硫醇
  参考文献：
  名称：

  Rossi,S. et al., Gazzetta Chimica Italiana, 1962, vol. 92, p. 1367 - 1378

  摘要：

  DOI：

文献信息

• Syntheses of N-(2-hexahydropyrimidinoethyl)propionanilides.
  作者：JUTARO OKADA、MASAHARU SHIMABAYASHI

  DOI：10.1248/cpb.28.3310

  日期：——

  N-(2-Hexahydropyrimidinoethyl) anilines (6a-f) were prepared by the condensation of N-(β-bromoethyl) aniline hydrobromide and hexahydropyrimidines. They were further converted to N-(2-hexahydropyrimidinoethyl) propionanilides by N-propionylation. The analgesic activities of the twelve compounds thus obtained were examined by subcutaneous administration to mice. Among the propionanilides, the N-isopropyl- and N-benzylhexahydropyrimidine derivatives (7c, e) possessed ca. 1/3 and 1/6 of the analgesic effect of pentazocine, respectively, and 7e showed a lower toxicity. On the other hand, the N-phenethyl derivative (7f) was inactive.

  N-(2-六氢嘧啶乙基)苯胺（6a-f）是由 N-(β-溴乙基)苯胺氢溴酸盐和六氢嘧啶缩合而成。它们通过 N-丙酰化进一步转化为 N-（2-六氢嘧啶乙基）丙酰苯胺。通过给小鼠皮下注射，对由此获得的 12 种化合物的镇痛活性进行了检测。在丙酰苯胺类化合物中，N-异丙基和 N-苄基六氢嘧啶衍生物（7c 和 7e）的镇痛效果分别约为喷他佐辛的 1/3 和 1/6，而且 7e 的毒性较低。另一方面，N-苯乙基衍生物（7f）没有活性。
• Radiation-protective Agents.I. Studies on N-Alkylated-2-(2-aminoethyl)thiopseudoureas and 1, 1-(Dithioethylene)diguanidines
  作者：Tohru Hino、Katsuko Tana-ami、Kazuko Yamada、Sanya Akaboshi

  DOI：10.1248/cpb.14.1193

  日期：——

  Ten kinds of N-substituted-2-(2-aminoethyl)thiopseudoureas (AETs) were prepared. 1'-Phenyl-AET (VI) gave 2-aminothiazoline derivative (XXIII) with one equivalent of alkali, while other AETs having at least one hydrogen atom at the amino nitrogen underwent intramolecular rearrangement to give MEGs. GEDs were prepared from these MEGs by mild oxidation. The NMR and IR spectra of these compounds were also discussed.

  制备了十种 N-取代的-2-(2-氨基乙基)硫代假脲类化合物（AET）。1'-Phenyl-AET (VI) 与一个当量的碱反应生成 2-氨基噻唑啉衍生物 (XXIII)，而其他在氨基氮上至少有一个氢原子的 AET 则发生分子内重排反应生成 MEG。用这些 MEG 通过温和氧化制备出 GED。此外，还讨论了这些化合物的核磁共振和红外光谱。
• Nitro-derivatives of the benzene series and their use in the dyeing of
  申请人：L'Oreal

  公开号：US04470826A1

  公开（公告）日：1984-09-11

  The invention provides novel nitro-paraphenylenediamine derivatives of the formula: ##STR1## in which R.sub.1 denotes an alkyl group, a monohydroxy- or polyhydroxy-alkyl group or an aminoalkyl group, the amino group of which is optionally monosubstituted or disubstituted by an alkyl group, and R.sub.2 denotes an alkyl group, or a cosmetically acceptable salt thereof. These derivatives are useful as direct dyes, especially for dyeing human hair.

  该发明提供了新的硝基对苯二胺衍生物，其化学式为：##STR1## 其中R.sub.1表示烷基，单羟基或多羟基烷基或氨基烷基，其氨基可以选择性地被烷基单取代或双取代，而R.sub.2表示烷基，或其化妆品可接受的盐。这些衍生物可用作直接染料，特别适用于染发。
• Tinctorial composition for keratin fibres, based on nitrated benzene
  申请人：L'Oreal

  公开号：US04637821A1

  公开（公告）日：1987-01-20

  A process for dyeing keratin fibres is disclosed which involved applying: (a) at least one dyestuff of the formula: ##STR1## in which R.sub.1 and R.sub.2 independently designate hydrogen, amino, alkylamino, --NH--aliphatic--(X).sub.m, dialkylamino or --N--(aliphatic-(X).sub.m).sub.2, R.sub.3 designates hydrogen, OH, alkoxy or --O--aliphatic-(X).sub.m "aliphatic" designates an aliphatic radical having 2 to 4 free valencies, m designates an integer from 1 to 3 such that if m=1 X represents OH, Cl, OCH.sub.3 or OCH.sub.2 CH.sub.2 OH, or, if m designates 2 or 3, X designates OH, and R.sub.4 designates hydrogen, alkyl or halogen, with the proviso that at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen, and that, if R.sub.1 and R.sub.2 are both other than hydrogen, R.sub.3 designates hydrogen, (b) at least one dyestuff of the formula: ##STR2## in which R.sub.5 designates hydrogen, amino, aminoalkyl, NH-aliphatic-(X).sub.m, N-(alkyl).sub.2, N-(aliphatic(X).sub.m).sub.2, or NHCH.sub.2 CH.sub.2 NH.sub.2, R.sub.6 designates hydrogen, OH, alkoxy, O-aliphatic(X).sub.m or O(CH.sub.2).sub.n NH.sub.2, R.sub.7 designates hydrogen, alkyl or halogen, A designates-Y-(CH.sub.2)--.sub.n, --OCH.sub.2 CHOH--CH.sub.2 -- or ##STR3## where R.sub.8 designates hydrogen or methyl, Y designates oxygen or --NH-- and n is an integer from 2 to 4, and m "aliphatic" and X are as defined above, with the proviso that, if Y designates --NH-- and R.sub.6 is other than hydrogen, R.sub.5 designates hydrogen, and, if Y is an oxygen atom, R.sub.6 designates hydrogen, the shade and chromaticity of the color obtained with the dyestuff(s) of formula (I) and the shade and chromaticity of the color obtained with the dyestuff(s) of formula (II) being such that .DELTA.H+.DELTA.C is less than or equal to 4.5

  揭示了一种染色角蛋白纤维的方法，其中涉及应用：(a)至少一种公式为：##STR1## 其中R.sub.1和R.sub.2分别代表氢，氨基，烷基氨基，--NH--脂肪基--(X).sub.m，二烷基氨基或--N--(脂肪基-(X).sub.m).sub.2，R.sub.3代表氢，OH，烷氧基或--O--脂肪基-(X).sub.m，“脂肪基”代表具有2至4个自由价的脂肪基，m代表整数1至3，使得如果m=1，X代表OH，Cl，OCH.sub.3或OCH.sub.2 CH.sub.2 OH，或如果m代表2或3，X代表OH，R.sub.4代表氢，烷基或卤素，但前提是R.sub.1，R.sub.2和R.sub.3中至少有一个不是氢，且如果R.sub.1和R.sub.2都不是氢，则R.sub.3代表氢，(b)至少一种公式为：##STR2## 其中R.sub.5代表氢，氨基，氨基烷基，NH-脂肪基-(X).sub.m，N-(烷基).sub.2，N-(脂肪基(X).sub.m).sub.2或NHCH.sub.2 CH.sub.2 NH.sub.2，R.sub.6代表氢，OH，烷氧基，O-脂肪基(X).sub.m或O(CH.sub.2).sub.n NH.sub.2，R.sub.7代表氢，烷基或卤素，A代表-Y-(CH.sub.2)--.sub.n，--OCH.sub.2 CHOH--CH.sub.2--或##STR3## 其中R.sub.8代表氢或甲基，Y代表氧或--NH--，n为2至4的整数，m“脂肪基”和X如上所定义，但前提是，如果Y代表--NH--且R.sub.6不是氢，则R.sub.5代表氢，如果Y是一个氧原子，则R.sub.6代表氢，使用公式(I)和公式(II)的染料的色调和色度以满足.DELTA.H + .DELTA.C小于或等于4.5。
• Derivatives of (4-(piperazin-1-yl-phenyloxymethyl)-1.3-dioxolan-2-ylmethyl)-1H-imidazoles and -1H-1.2.4-triazoles, their preparation and use as fungicides and bactericides
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0006722A1

  公开（公告）日：1980-01-09

  Compounds having the formula: and the pharmaceutically acceptable acid addition salts and stersochemically isomeric forms thersof, wherein: Q is a member selected from the group consisting of N and CH; Ar is a member selected from the group consisting of thienyl, halothienyl, phenyl and substituted phenyl; and Y is a member selected from the group consisting of a) SO2R1, wherein R' is trifluormethyl and aryl and b) substituted alkyl and alkenyl. The compounds are useful as antifungal and antibacterial agents.

  具有以下式子的化合物：及其药学上可接受的酸加成盐和异构体，其中：Q 是选自 N 和 CH 组成的组的成员；Ar 是选自噻吩基、卤代噻吩基、苯基和取代苯基组成的组的成员；Y 是选自 a) SO2R1（其中 R' 为三氟甲基和芳基）和 b) 取代烷基和烯基组成的组的成员。 这些化合物可用作抗真菌剂和抗菌剂。