N-ethyl-N-(2-hydroxyethyl)benzamide | 21010-54-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-N-(2-hydroxyethyl)benzamide
• 英文别名: N-(2-Hydroxy-ethyl)-N-ethyl-benzamid；N-β-Hydroxyethyl-N-Ethylbenzamid；N-Aethyl-N-(2-hydroxy-aethyl)-benzamid
• CAS: 21010-54-8
• 化学式: C₁₁H₁₅NO₂
• mdl: MFCD11916095
• 分子量: 193.246
• InChiKey: DEQCOBZTSSIPMT-UHFFFAOYSA-N

物化性质

• 沸点：
  138 °C(Press: 0.05 Torr)
• 密度：
  1.102±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-ethyl-N-(2-hydroxyethyl)benzamide 在 戴斯-马丁氧化剂 、 sodium sulfite 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  WO2007/19234

  摘要：

  公开号：
• 作为产物：
  描述：

  N-(2-Chlor-ethyl)-N-ethyl-benzamid 在 水 作用下， 生成 N-ethyl-N-(2-hydroxyethyl)benzamide
  参考文献：
  名称：

  Nerdel,F. et al., Justus Liebigs Annalen der Chemie, 1968, vol. 716, p. 127 - 134

  摘要：

  DOI：

文献信息

• Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation
  作者：Nikolai A. Sitte、Markus Bursch、Stefan Grimme、Jan Paradies

  DOI：10.1021/jacs.8b12997

  日期：2019.1.9

  reductant is introduced. The reaction proceeds via the hydrogen splitting by B(2,6-F2-C6H3)3 in combination with chloride as the Lewis base. Density functional theory calculations support the unprecedented role of halides as active Lewis base components in the frustrated Lewis pair mediated hydrogen activation. The reaction displays broad substrate scope for tertiary benzoic acid amides and α-branched carboxamides

  介绍了一种以草酰氯为活化剂、氢气为最终还原剂的羧酸酰胺无金属还原方法。该反应通过 B(2,6-F2-C6H3)3 与作为路易斯碱的氯化物组合进行氢分解而进行。密度泛函理论计算支持卤化物作为活性路易斯碱组分在受挫的路易斯对介导的氢活化中的前所未有的作用。该反应对叔苯甲酸酰胺和 α-支链甲酰胺显示出广泛的底物范围。
• Ionic Liquids for Separation of Olefin-Paraffin Mixtures
  申请人：Dai Sheng

  公开号：US20110015461A1

  公开（公告）日：2011-01-20

  The invention is directed to an ionic liquid comprising (i) a cationic portion containing a complex of a silver (I) ion and one or more neutral ligands selected from organoamides, organoamines, olefins, and organonitriles, and (ii) an anionic portion having the chemical formula wherein m and n are independently 0 or an integer of 1 or above, and p is 0 or 1, provided that when p is 0, the group —N—SO 2 —(CF 2 ) n CF 3 subtended by p is replaced with an oxide atom connected to the shown sulfur atom. The invention is also directed to a method for separating an olefin from an olefin-paraffin mixture by passing the mixture through a layer of the ionic liquid described above.

  该发明涉及一种离子液体，包括（i）含有银（I）离子的阳离子部分，该离子与来自有机酰胺、有机胺、烯烃和有机腈中选择的一个或多个中性配体形成的络合物，以及（ii）具有化学式的阴离子部分，其中m和n独立地为0或大于1的整数，p为0或1，但当p为0时，由p支撑的基团—N—SO2—(CF2)nCF3将被连接到所示硫原子的氧原子替代。该发明还涉及一种从烯烃烷烃混合物中分离烯烃的方法，通过将混合物经过上述离子液体的一层来实现。
• Aminoethane Sulfonamide Orexin Receptor Antagonists
  申请人：Coleman Paul J.

  公开号：US20090258903A1

  公开（公告）日：2009-10-15

  The present invention is directed to aminoethane sulfonamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及氨基乙磺酰胺化合物，其是促进睡眠的荷尔蒙受体拮抗剂，可用于治疗或预防神经和精神障碍以及涉及荷尔蒙受体的疾病。该发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及荷尔蒙受体的疾病中使用这些化合物和组合物。
• Arteriovenous hemangioma involving submandibular salivary gland
  作者：P. P. Singh、Neelima Gupta、Mona Jain

  DOI：10.1007/bf02910983

  日期：2001.1

  We present a case of an arteriovenous hemangioma involving the submandibular salivary gland in a 20 year old girl. Hemangiomas in this region are rare. Out of the reported cases most have been cavernous hemangiomas. The rarity of an arteriovenous malformation in the submandibular salivary gland prompted us to report this case.
• IONIC LIQUIDS FOR SEPARATION OF OLEFIN-PARAFFIN MIXTURES
  申请人：UT-Battelle, LLC

  公开号：US20130338389A1

  公开（公告）日：2013-12-19

  The invention is directed to an ionic liquid comprising (i) a cationic portion containing a complex of a silver (I) ion and one or more neutral ligands selected from organoamides, organoamines, olefins, and organonitriles, and (ii) an anionic portion having the chemical formula wherein m and n are independently 0 or an integer of 1 or above, and p is 0 or 1, provided that when p is 0, the group —N—SO 2 —(CF 2 ) n CF 3 subtended by p is replaced with an oxide atom connected to the shown sulfur atom. The invention is also directed to a method for separating an olefin from an olefin-paraffin mixture by passing the mixture through a layer of the ionic liquid described above.