3-amino-3-(pyridin-3-yl)propan-1-ol | 127025-91-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-amino-3-(pyridin-3-yl)propan-1-ol
• 英文别名: 3-amino-3-pyridin-3-ylpropan-1-ol
• CAS: 127025-91-6
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: MHDKZNTVSJLQHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-amino-3-(pyridin-3-yl)propan-1-ol 在 偶氮二甲酸二叔丁酯 、 三苯基膦 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 1-(3-Amino-3-pyridin-3-yl-propyl)-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
  参考文献：
  名称：

  Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists

  摘要：

  SAR studies of 1, 3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.038
• 作为产物：
  描述：

  3-吡啶甲醛 在 乙酸铵 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 16.0h， 生成 3-amino-3-(pyridin-3-yl)propan-1-ol
  参考文献：
  名称：

  Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists

  摘要：

  SAR studies of 1, 3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.038

文献信息

• Regioselectively Functionalized Pyridines from Sustainable Resources
  作者：Stefan Michlik、Rhett Kempe

  DOI：10.1002/anie.201301919

  日期：2013.6.10

  Ir‐catalyzed dehydrogenative condensation of alcohols and 1,3‐amino alcohol was used to construct pyridine derivatives regioselectively. This method provides access to unsymmetrically substituted pyridines and tolerates a wide variety of functional groups. Three equivalents of H2 are generated per pyridine unit formed and the alcohol substrates become completely deoxygenated.

  充分利用它！醇和1,3-氨基醇的Ir催化脱氢缩合反应用于区域选择性地构建吡啶衍生物。该方法提供了不对称取代的吡啶的途径，并能耐受多种官能团。每个形成的吡啶单元产生三当量的H 2，醇底物完全脱氧。
• TUBULIN INHIBITORS
  申请人：YM Biosciences Australia Pty Ltd. c/o Gilead Sciences, Inc.

  公开号：US20160031835A1

  公开（公告）日：2016-02-04

  Compounds of general formula (I), (II), (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also described. Further described are novel compounds of formula (II), (III) and (V).

  本文描述了通式(I)、(II)、(III)和(V)的化合物，用于调节微管聚合并治疗相关疾病状态。还描述了化合物(I)、(III)和(V)在治疗激酶相关疾病状态方面的应用。进一步描述了通式(II)、(III)和(V)的新化合物。
• US9732046B2
  申请人：——

  公开号：US9732046B2

  公开（公告）日：2017-08-15
• Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists
  作者：Zhiqiang Guo、Dongpei Wu、Yun-Fei Zhu、Fabio C. Tucci、Collin F. Regan、Martin W. Rowbottom、R. Scott Struthers、Qiu Xie、Shelby Reijmers、Susan K. Sullivan、Yang Sai、Chen Chen

  DOI：10.1016/j.bmcl.2005.05.038

  日期：2005.8

  SAR studies of 1, 3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM. (c) 2005 Elsevier Ltd. All rights reserved.