ethyl 3-bromo-4-oxochromene-2-carboxylate | 87930-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: ethyl 3-bromo-4-oxochromene-2-carboxylate
• 英文别名: ethyl 3-bromo-4-oxochromen-2-carboxylate；3-Bromo-2-ethoxycarbonylchromone
• CAS: 87930-53-8
• 化学式: C₁₂H₉BrO₄
• 分子量: 297.105
• InChiKey: OJIFHUZLFUXZLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 3-bromo-4-oxochromene-2-carboxylate 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 3.5h， 以63.5%的产率得到3-bromo-4-oxochromene-2-carboxylic acid
  参考文献：
  名称：

  Bevan, Peter S.; Ellis, Gwynn P.; Hudson, Henrietta V., Journal of the Chemical Society. Perkin transactions I, 1986, p. 1643 - 1650

  摘要：

  DOI：
• 作为产物：
  描述：

  2'-乙酰氧基苯乙酮 在 硫酸 、 溴 、 sodium ethanolate 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 ethyl 3-bromo-4-oxochromene-2-carboxylate
  参考文献：
  名称：

  Bevan, Peter S.; Ellis, Gwynn P., Journal of the Chemical Society. Perkin transactions I, 1983, # 8, p. 1705 - 1709

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS<br/>[FR] DERIVES DE PIPERIDINE ET DE PIPERAZINE SUBSTITUES UTILISES EN TANT QUE MODULATEURS DU RECEPTEUR DE LA MELANOCORTINE-4
  申请人：MYOCONTRACT LTD

  公开号：WO2004083208A1

  公开（公告）日：2004-09-30

  The present invention relates to novel substituted piperidine and piperazine derivatives as melanocortin-4 receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders, where the regulation of the MC-4R is involved, can be treated with the compounds of the invention.

  本发明涉及一种新型的替代哌啶和哌嗪衍生物，作为黑色素皮质素-4受体（MC-4R）调节剂。本发明的MC-4R激动剂可用于治疗肥胖、糖尿病和性功能障碍等疾病，而MC-4R拮抗剂可用于治疗癌症恶病质、肌肉消耗、厌食症、焦虑和抑郁等疾病。所有涉及MC-4R调节的疾病和障碍均可使用本发明的化合物治疗。
• Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators
  申请人：MyoContract Ltd.

  公开号：EP1460073A1

  公开（公告）日：2004-09-22

  The present invention relates to novel substituted piperidine and piperazine derivatives as melanocortin-4 receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes, and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.

  本发明涉及作为黑色素皮质素-4受体（MC-4R）调节剂的新型取代哌啶和哌嗪衍生物。本发明的MC-4R激动剂可用于治疗肥胖、糖尿病和性功能障碍等疾病，而MC-4R拮抗剂可用于治疗癌症恶病质、肌肉消耗、厌食症、焦虑和抑郁等疾病。所有涉及MC-4R调节的疾病和障碍均可通过本发明的化合物进行治疗。
• Substituted cyclohexyl and piperidinyl derivatives as melanocortin-4 receptor modulators
  申请人：MyoContract Ltd.

  公开号：EP1460069A1

  公开（公告）日：2004-09-22

  The present invention relates to novel substituted cyclohexyl and piperidinyl derivatives as melanocortin-4 receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.

  本发明涉及新型取代环己基和哌啶基衍生物，作为黑色素皮质激素-4受体（MC-4R）调节剂。本发明的MC-4R激动剂可用于治疗肥胖、糖尿病和性功能障碍等疾病，而MC-4R拮抗剂可用于治疗癌症恶病质、肌肉消耗、厌食症、焦虑和抑郁等疾病。所有需要MC-4R调节的疾病和障碍都可以用本发明的化合物进行治疗。
• [EN] SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS<br/>[FR] DERIVES A SUBSTITUTION PIPERIDINE ET PIPERAZINE AGISSANT COMME MODULATEURS DU RECEPTEUR DE LA MELANOCORTINE 4
  申请人：MYOCONTRACT LTD

  公开号：WO2004083199A1

  公开（公告）日：2004-09-30

  The present invention relates to novel substituted piperidine and piperazine derivatives as melanocortin-4 receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes, and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.

  本发明涉及一种新型的取代哌啶和哌嗪衍生物，作为黑色素皮质素-4受体（MC-4R）调节剂。本发明中的MC-4R激动剂可用于治疗肥胖症、糖尿病和性功能障碍等疾病和疾病，而MC-4R拮抗剂则可用于治疗癌症恶病质、肌肉萎缩、厌食、焦虑和抑郁等疾病和疾病。所有涉及MC-4R调节的疾病和疾病都可以用本发明中的化合物进行治疗。
• Substituted cyclohexyl and piperidinyl derivates as melanocortin-4 receptor modulators
  申请人：Soeberdt Michael

  公开号：US20070155783A1

  公开（公告）日：2007-07-05

  The present invention relates to novel substituted cyclohexyl and piperidinyl derivatives as melanocortin-4. receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.

  本发明涉及一种新型的取代环己基和哌啶基衍生物，作为黑色素皮质素-4受体（MC-4R）调节剂。本发明中的MC-4R激动剂可用于治疗肥胖症、糖尿病和性功能障碍等疾病和疾病，而MC-4R拮抗剂则可用于治疗癌症消瘦、肌肉消耗、厌食、焦虑和抑郁等疾病和疾病。所有涉及MC-4R调节的疾病和疾病均可使用本发明中的化合物进行治疗。