2,4,5-涕酸丁氧基乙酯 | 2545-59-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4,5-涕酸丁氧基乙酯
• 中文别名: 2,4,5-涕酸丁氧乙酯；2,4,5-T-丁氧基乙酯
• 英文名称: (2,4,5-trichloro-phenoxy)-acetic acid-(2-butoxy-ethyl ester)
• 英文别名: (2,4,5-Trichlor-phenoxy)-essigsaeure-(2-butoxy-aethylester)；2-butoxyethyl 2,4,5-trichlorophenoxyacetate；2,4,5-trichlorophenoxyacetic acid, butoxy-ethanol ester；2,4,5-T butoxyethyl ester；2-butoxyethyl 2-(2,4,5-trichlorophenoxy)acetate
• CAS: 2545-59-7
• 化学式: C₁₄H₁₇Cl₃O₄
• 分子量: 355.646
• InChiKey: GLDWASBMYWLQGG-UHFFFAOYSA-N

物化性质

• 沸点：
  163-166 °C
• 密度：
  1.280 g/cm3
• 闪点：
  265-420 °F (OPEN CUP) /2,4,5-T ESTERS/
• 溶解度：
  Insol in water, sol in oils
• 蒸汽压力：
  1.5X10-6 mm Hg at 25 °C
• 腐蚀性：
  May attack some forms of plastics /2,4,5-T esters/

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

代谢

氯苯氧基化合物...不会广泛代谢，但会被积极排泄...。/氯苯氧基除草剂/

CHLOROPHENOXY CMPD ... ARE NOT EXTENSIVELY METAB BUT ARE ACTIVELY EXCRETED ... . /CHLOROPHENOXY HERBICIDES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

致癌性分类：1）人类的证据：有限；对人类致癌风险的总评估为2B组：该物质可能对人类致癌。/氯苯氧基除草剂；来自表格/

Classification of carcinogenicity: 1) evidence in humans: limited; Overall summary evaluation of carcinogenic risk to humans is Group 2B: The agent is possibly carcinogenic to humans. /Chlorophenoxy herbicides; From table/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A4；不可分类为人类致癌物。/2,4,5-T/

A4; Not classifiable as a human carcinogen. /2,4,5-T/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒病例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

使用肥皂和水洗澡和洗头以去除皮肤和头发上的化学品。如果出现持续刺激，请寻求医疗治疗。患有慢性皮肤病或对这些除草剂已知敏感的个人应避免使用它们，或采取严格预防措施以避免接触（如使用呼吸器、手套等）。用大量清水冲洗受污染的眼睛10-15分钟。如果刺激持续，请寻求医疗治疗。/氯苯氧基化合物/

Bath and shampoo with soap and water to remove chemicals from skin and hair. Obtain medical treatment if irritation persists. Individuals with chronic skin disease or known sensitivity to these herbicides should either avoid using them or take strict precautions to avoid contact (respirator, gloves, etc). FLUSH contaminating chemicals from eyes and copious amounts of clean water for 10-15 minutes. If irritation persists, obtain medical treatment. /Chlorophenoxy compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

如果在吸入喷雾期间或之后出现任何疾病症状，请将受害者与该物质接触至少2-3天。只有在实践有效的呼吸防护的情况下，才允许随后接触氯苯氧基化合物。/氯苯氧基化合物/

If any symptoms of illness occur during or following inhalation of spray, remove victim from contact with the material for at least 2-3 days. Allow subsequent contact with chlorophenoxy compounds only if effective respiratory protection is practiced. /Chlorophenoxy compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

给绵羊口服2,4,5-T醋酸酯25毫克/公斤，3-4小时后在其血浆中发现了10PPM的峰值浓度；在72小时内，从尿液中回收了86%的给药剂量，且形式未变，1.4%以自由酸形式存在。组织中2,4,5-T的含量不到0.1PPM，但是，在反复服用2,4,5-T中毒的绵羊组织中，其含量为368PPM。/2,4,5-T醋酸酯/

IN SHEEP GIVEN ORAL DOSE OF 25 MG/KG OF 2,4,5-T ESTER PEAK PLASMA CONCN OF 10 PPM ... FOUND 3-4 HR LATER; 86% OF ADMIN DOSE WAS RECOVERED FROM URINE IN UNALTERED FORM, & 1.4% AS FREE ACID, WITHIN 72 HR. THERE WAS LESS THAN 0.1 PPM OF 2,4,5-T IN TISSUES, BUT IN SHEEP POISONED BY REPEATED DOSES OF 2,4,5-T TISSUE LEVELS WERE 368 PPM. /2,4,5-T ESTERS/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

氯苯氧基化合物通过肠道壁、肺和皮肤吸收。它们不会显著储存在脂肪中。排泄几乎完全通过尿液进行。/氯苯氧基除草剂/

The chlorophenoxy compounds are absorbed across the gut wall, lung, and skin. They are not significantly fat storable. Excretion occurs almost entirely by way of the urine. /Chlorophenoxy herbicides/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  Xn,N
• 安全说明：
  S24,S60,S61
• 危险类别码：
  R22,R36/37/38,R50/53
• 海关编码：
  2918990090

反应信息

• 作为产物：
  描述：

  乙二醇单丁醚 、 2,4,5-涕 生成 2,4,5-涕酸丁氧基乙酯
  参考文献：
  名称：

  Herbicidal compositions containing esters of chlorinated phenoxyacetic acids

  摘要：

  公开号：

  US02543397A1

文献信息

• Microfibrillated cellulose as rheology modifier in high ionic strength agricultural formulations
  申请人：AMVAC Chemical Corporation

  公开号：US11358905B2

  公开（公告）日：2022-06-14

  Described herein, inter alia, is a concentrate including a high ionic strength liquid and a microfibrillated cellulose, and methods of making the same.

  本文特别描述了一种浓缩物，包括一种高离子强度液体和一种微纤维化纤维素，以及制造这种浓缩物的方法。
• PRODUCE PRESERVATION BY MEMBRANOUS COATING PROCESS
  申请人：INTERNATIONAL APPLIED SCIENCES, INC.

  公开号：EP0462987A1

  公开（公告）日：1992-01-02
• PARTIALLY ENCAPSULATED PLANT CUTTINGS
  申请人：Dümmen Group B.V.

  公开号：EP3302023A1

  公开（公告）日：2018-04-11
• METHOD FOR IMPROVING THE VIGOUR OF PLANT CUTTINGS AND PARTIALLY ENCAPSULATED PLANT CUTTINGS
  申请人：Dümmen Group B.V.

  公开号：EP3302023B1

  公开（公告）日：2021-07-07
• PESTICIDE FORMULATION COMPRISING MFC AS RHEOLOGY MODIFIER
  申请人：AMVAC Hong Kong Limited

  公开号：EP3914075A1

  公开（公告）日：2021-12-01

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