N-(1-methyl-piperidin-4-yl)-N-phenyl-propionamide | 22261-99-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-methyl-piperidin-4-yl)-N-phenyl-propionamide
• 英文别名: N-(1-methyl-4-piperidinyl)-N-phenylpropionamide；N-Methylfentanyl；N-(1-methylpiperidin-4-yl)-N-phenylpropanamide
• CAS: 22261-99-0
• 化学式: C₁₅H₂₂N₂O
• 分子量: 246.352
• InChiKey: PCMUWYHREXSXFM-UHFFFAOYSA-N

物化性质

• 沸点：
  353.5±35.0 °C(Predicted)
• 密度：
  1.065±0.06 g/cm3(Predicted)
• 保留指数：
  2018

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-methyl-piperidin-4-yl)-N-phenyl-propionamide 在 双氧水 作用下， 以 甲醇 为溶剂， 生成 1-甲基-4-(N-苯基丙酰胺基)哌啶1-氧化物
  参考文献：
  名称：

  Groutas, W.C.; Essawi, M.; Portoghese, P.S., Synthetic Communications, 1980, vol. 10, # 7, p. 495 - 502

  摘要：

  DOI：

文献信息

• NOVEL VANILLOID RECEPTOR LIGANDS AND USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS
  申请人：Lee Jeewoo

  公开号：US20070105861A1

  公开（公告）日：2007-05-10

  The present invention relates to novel vanilloid receptor ligands, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use of these compounds for the production of pharmaceutical preparations.

  本发明涉及新型辣椒素受体配体，以及用于其生产的方法，含有这些化合物的药物制剂以及利用这些化合物生产药物制剂的用途。
• Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
  申请人：Randox Laboratories Limited

  公开号：US20030170728A1

  公开（公告）日：2003-09-11

  The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of metabolites of fentanyl and of metabolites of fentanyl analogs.

  该发明提供了一种免疫原，其中包括一个与赋予抗原性载体材料偶联的半抗原，以及一个包括前述半抗原与标记剂偶联的结合物，还提供了针对前述免疫原产生的抗体，这些抗体能够结合芬太尼代谢物和芬太尼类似物代谢物的至少一个结构表位。
• Uses of rifamycins
  申请人：Murphy K. Christopher

  公开号：US20070142392A1

  公开（公告）日：2007-06-21

  The invention features methods, compositions, and kits for treating prosthetic joint infections, foreign body infections, infectious arthritis, and osteomyelitis
• Rifamycin analogs and uses thereof
  申请人：van Duzer John H.

  公开号：US20100273765A1

  公开（公告）日：2010-10-28

  The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, 4′- and/or 6′ halo and/or alkoxy analogs, and various 5′ substituents that incorporate a cyclic amine moiety.
• Novel Vanilloid Receptor Ligands and Use Thereof for the Production of Pharmaceutical Preparations
  申请人：Gruenenthal GmbH

  公开号：US20140179686A1

  公开（公告）日：2014-06-26

  The present invention relates to novel vanilloid receptor ligands, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use of these compounds for the production of pharmaceutical preparations.