<2-Hydroxy-ethylimino>-cyclohexan | 2875-38-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: <2-Hydroxy-ethylimino>-cyclohexan
• 英文别名: 2-cyclohexylideneamino-ethanol；2-(Cyclohexylideneamino)ethan-1-ol；2-(cyclohexylideneamino)ethanol
• CAS: 2875-38-9
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: OKPMIZBLVWRAJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  <2-Hydroxy-ethylimino>-cyclohexan 在 sulfur 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-(2-acetoxy-ethyl)-4,5,6,7-tetrahydro-1H-benzo[c]isothiazole-3-thione
  参考文献：
  名称：

  Mayer,R. et al., Journal fur praktische Chemie (Leipzig 1954), 1966, vol. 31, p. 312 - 319

  摘要：

  DOI：
• 作为产物：
  描述：

  环己酮 、 C.I.酸性橙108 在 potassium carbonate 作用下， 反应 1.0h， 生成 <2-Hydroxy-ethylimino>-cyclohexan
  参考文献：
  名称：

  SYNTHESIS OF SOME NEW CYCLIC AMINOPHOSPHONATES AND THEIR PHYSIOLOGICAL ACTIVITIES

  摘要：

  The synthesis of 19 newly synthesized cyclic aminophosphonic acid derivatives was described and their biological activity studied. It was found, as in the case of the previously described series of acyclic analogues, that the phytotoxicity of the compounds, tested on aquatic plant Spirodela oligorrhiza depended mainly on their hydrophobic parameters. The most pronounced phytotoxicity, the measure of which was concentration of aminophosphonates causing 50% inhibition of plant growth (EC50), exhibited compounds with not too long hydrocarbon substituent on the nitrogen atom (8-10 carbon atoms) and branched propyl groups on the phosphorus atom. The test had preliminary character and permitted to eliminate the less promising compounds for further studies.

  DOI：

  10.1080/10426500108040237

文献信息

• Heterobifunctional poly(ethyleneglycol) containing acid-labile amino protecting groups and uses thereof
  申请人：Breitenkamp Kurt

  公开号：US20080188638A1

  公开（公告）日：2008-08-07

  The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

  本发明提供了双功能聚合物，其制备方法以及中间体。这些化合物在各种应用中都有用，包括对生物活性分子进行聚乙二醇化。本发明还提供了使用这些化合物和其组成物的方法。
• US8212083B2
  申请人：——

  公开号：US8212083B2

  公开（公告）日：2012-07-03