2-Cl-Ph-CH2OCMe3 | 56636-81-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Cl-Ph-CH2OCMe3
• 英文别名: 1-[(Tert-butoxy)methyl]-2-chlorobenzene；1-chloro-2-[(2-methylpropan-2-yl)oxymethyl]benzene
• CAS: 56636-81-8
• 化学式: C₁₁H₁₅ClO
• 分子量: 198.692
• InChiKey: YBHHVCGHCNVRJO-UHFFFAOYSA-N

物化性质

• 沸点：
  236.7±15.0 °C(Predicted)
• 密度：
  1.045±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二碳酸二叔丁酯 、 邻氯苄醇 在 saccharin sulfonic acid 作用下， 以 正己烷 为溶剂， 反应 4.0h， 以90%的产率得到2-Cl-Ph-CH2OCMe3
  参考文献：
  名称：

  糖精磺酸催化胺的N-Boc保护和由醇形成叔丁基醚

  摘要：

  通过在室温下使糖精与纯净的氯磺酸反应，可以容易地制备作为稳定试剂的糖精磺酸（SaSA）。该化合物能够用（Boc）2 O催化胺转化为其相应的N- Boc保护的胺。醇也被转化为其相应的叔丁基醚。所有反应均在温和条件下进行，以高至高收率得到所需产物。

  DOI：

  10.1007/bf03246047

文献信息

• Pyrrole and pyrazole derivatives as potentiators of glutamate receptors
  申请人：Albaugh Ann Pamela

  公开号：US20070066573A1

  公开（公告）日：2007-03-22

  The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.

  本发明涉及式(I)的吡咯和吡唑化合物及其药学上可接受的盐，并进一步涉及它们在治疗精神分裂症、与精神分裂症相关的认知缺陷、阿尔茨海默病、阿尔茨海默型痴呆、轻度认知障碍或抑郁症方面的使用。这些化合物在谷氨酸受体上发挥增强剂作用，特别是AMPA和GluR家族。
• Glutamine transport inhibitors and methods for treating cancer
  申请人：Vanderbilt University

  公开号：US10793514B2

  公开（公告）日：2020-10-06

  The present disclosure provides compounds of formula: wherein R1, R2, and n are defined as set forth in the specification, and related aminobutanoic acids. The present disclosure also provides compositions comprising these compounds and methods for modulating ASCT2 function in a patient in need thereof.

  本公开提供了式化合物： 其中 R1、R2 和 n 的定义如说明书所述，以及相关的氨基丁酸。本公开还提供了包含这些化合物的组合物，以及在有需要的患者中调节 ASCT2 功能的方法。
• Ruechardt,C.; Grundmeier,M., Chemische Berichte, 1975, vol. 108, p. 2448 - 2464
  作者：Ruechardt,C.、Grundmeier,M.

  DOI：——

  日期：——
• CARBOCYCLIC SULFONE ROR GAMMA MODULATORS
  申请人：BRISTROL-MYERS SQUIBB COMPANY

  公开号：US20160326103A1

  公开（公告）日：2016-11-10

  Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
• Glutamine Transport Inhibitors and Methods for Treating Cancer
  申请人：Vanderbilt University

  公开号：US20200095190A1

  公开（公告）日：2020-03-26

  The present disclosure provides compounds of formula: wherein R 1 , R 2 , and n are defined as set forth in the specification, and related aminobutanoic acids. The present disclosure also provides compositions comprising these compounds and methods for modulating ASCT2 function in a patient in need thereof.