saccharin sulfonic acid | 1174495-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: saccharin sulfonic acid
• 英文别名: SaSA；1,1,3-trioxo-1,2-benzothiazole-2-sulfonic acid
• CAS: 1174495-97-6
• 化学式: C₇H₅NO₆S₂
• 分子量: 263.252
• InChiKey: FWLIRCFOOMVZKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  糖精 在 氯磺酸 作用下， 以90%的产率得到saccharin sulfonic acid
  参考文献：
  名称：

  Chemoselective trimethylsilylation of alcohols catalyzed by saccharin sulfonic acid

  摘要：

  Saccharin sulfonic acid was easily prepared by the reaction of saccharin with neat chlorosulfonic acid at room temperature. This reagent is efficiently able to catalyze the chemoselective trimethylsilylation of alcohols with hexamethyldisilazane in the presence of amines and thiols.

  DOI：

  10.1007/s00706-008-0004-7
• 作为试剂：
  描述：

  丁二酰亚胺 、 二碳酸二叔丁酯 在 saccharin sulfonic acid 作用下， 以 正己烷 为溶剂， 反应 4.0h， 以90%的产率得到2,5-二氧代吡咯烷-1-羧酸叔丁酯
  参考文献：
  名称：

  糖精磺酸催化胺的N-Boc保护和由醇形成叔丁基醚

  摘要：

  通过在室温下使糖精与纯净的氯磺酸反应，可以容易地制备作为稳定试剂的糖精磺酸（SaSA）。该化合物能够用（Boc）2 O催化胺转化为其相应的N- Boc保护的胺。醇也被转化为其相应的叔丁基醚。所有反应均在温和条件下进行，以高至高收率得到所需产物。

  DOI：

  10.1007/bf03246047

文献信息

• Saccharin Sulfonic Acid (SASA) as a Highly Efficient Catalyst for the Condensation of 2-Naphthol With Arylaldehydes and Amides (Thioamides or Alkyl Carbamates) Under Green, Mild, and Solvent-Free Conditions
  作者：Abdolkarim Zare、Hamideh Kaveh、Maria Merajoddin、Ahmad Reza Moosavi-Zare、Alireza Hasaninejad、Mohammad Ali Zolfigol

  DOI：10.1080/10426507.2012.692131

  日期：2013.5.1

  Abstract Saccharin sulfonic acid (SaSA) is used as a highly efficient and recyclable catalyst for the one-pot multicomponent condensation of 2-naphthol with arylaldehydes and amides (thioamides or alkyl carbamates) under green, mild (70 °C), and solvent-free conditions. In this reaction, 1-amidoalkyl-2-naphthols, 1-thioamidoalkyl-2-naphthols, 1-carbamatoalkyl-2-naphthols, bis(1-amidoalkyl-2-naphthol)s

  摘要 糖精磺酸 (SaSA) 是一种高效、可回收的催化剂，用于 2-萘酚与芳醛和酰胺（硫代酰胺或氨基甲酸烷基酯）在绿色、温和 (70 °C) 和溶剂下的一锅多组分缩合反应。免费条件。在该反应中，1-酰氨基烷基-2-萘酚、1-硫代酰氨基烷基-2-萘酚、1-氨基甲酰烷基-2-萘酚、双(1-酰氨基烷基-2-萘酚)和双(1-氨基甲酰烷基-2-萘酚) )s 以高到极好的收率和相对较短的反应时间生产。补充材料可用于本文。转至出版商在线版的磷、硫和硅及相关元素，查看免费的补充文件。图形概要
• GAMBOGIC ACID CYCLIZATION ANALOGUES, THEIR PREPARATION METHOD AND APPLICATION THEREOF
  申请人：Xu Lifeng

  公开号：US20130039904A1

  公开（公告）日：2013-02-14

  The present invention discloses a gamboge acid cyclization analogs, their preparation methods and applications by semi-synthesis with the following structural formula I-III: Where ring A, ring B or/and ring C is 4-10 membered saturated or/and unsaturated aliphatic ring aliphatic heterocycle or aryl heterocycle. R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 or/and R 12 is, independently at each occurrence, optionally substituted substituent of glycosyl, multi-hydroxyl, amino acid, acyloxy, phosphoric acid oxy, sulfonyloxy, alkoxy, aryloxy, heterocyclic oxy, thiol, aliphatic or cyclic group containing oxygen, sulfur, nitrogen or phosphorus, one of the substituents or combinations thereof. The present invention has antitumor activity management, antiviral, antibacterial and antifungal activity management, as anti-tumor, anti-viral, immune, antibacterial and antifungal agents, with other known anti-tumor, anti-viral, immune, together with the application of antibacterial and antifungal.

  本发明公开了一种橙黄酸环化类似物，其制备方法和应用通过半合成具有以下结构式I-III：其中环A、环B或/和环C为4-10元饱和或/和不饱和脂肪环脂环或芳基环。R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11或/和R12，在每次出现时，独立地是可选的糖基、多羟基、氨基酸、酰氧、磷酸氧、磺酰氧、烷氧基、芳氧基、杂环氧基、硫醇、含氧、硫、氮或磷的脂肪或环状基团的取代基或其组合物。本发明具有抗肿瘤活性管理、抗病毒、抗细菌和抗真菌活性管理，作为抗肿瘤、抗病毒、免疫、抗细菌和抗真菌药剂，与其他已知的抗肿瘤、抗病毒、免疫、抗细菌和抗真菌的应用一起。
• GAMBOGIC GLYCOSIDE DERIVATIVES AND ANALOGS, THE PREPARATION AND THE APPLICATION THEREOF
  申请人：Liaoning Lifeng Scientific&Technology Development Company Ltd.

  公开号：EP2223929A1

  公开（公告）日：2010-09-01

  This invention relates with the gambogic acid glycoside derivatives and analogs of formula I: or stereoisomers, tautoers, prodrugs, pharmaceutically acceptable salts, complex salts or solvates thereof, wherein: X1, X2, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 or/and R12 is, independently at each occurrence, optionally substituted glycosyl, optionally substituted multi-hydroxyl, optional substituent oxy, optional substituent containing carbon, oxygen, sulfur, nitrogen or phosphorus element. Compounds of the present invention are useful as therapeutically effective agents of anti-cancer, anti-virus and anti-bacterial. This invention also relates with their preparative methods and applications.

  本发明涉及式 I 的甘草酸苷衍生物和类似物： 或其立体异构体、同系物、原药、药学上可接受的盐、复盐或溶液，其中： X1、X2、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11 或/和 R12 在每次出现时独立地是任选取代的糖基、任选取代的多羟基、任选取代基氧基、任选取代基含碳、氧、硫、氮或磷元素。本发明的化合物可作为抗癌、抗病毒和抗菌的有效治疗剂。 本发明还涉及其制备方法和应用。
• GAMBOGIC ACID GLYCOSIDE DERIVATIVES AND ANALOGS, THEIR PREPARATION METHODS AND APPLICATIONS
  申请人：Xu Lifeng

  公开号：US20110038952A1

  公开（公告）日：2011-02-17

  This invention relates with the gambogic acid glycoside derivatives and analogs of formula I: or stereoisomers, tautoers, prodrugs, pharmaceutically acceptable salts, complex salts or solvates thereof, wherein: X 1 , X 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 or/and R 12 is, independently at each occurrence, optionally substituted glycosyl, optionally substituted multi-hydroxyl, optional substituent oxy, optional substituent containing carbon, oxygen, sulfur, nitrogen or phosphorus element. Compounds of the present invention are useful as therapeutically effective agents of anti-cancer, anti-virus and anti-bacterial. This invention also relates with their preparative methods and applications.
• Chemoselective trimethylsilylation of alcohols catalyzed by saccharin sulfonic acid
  作者：Farhad Shirini、Mohammad Ali Zolfigol、Masoumeh Abedini

  DOI：10.1007/s00706-008-0004-7

  日期：2009.1

  Saccharin sulfonic acid was easily prepared by the reaction of saccharin with neat chlorosulfonic acid at room temperature. This reagent is efficiently able to catalyze the chemoselective trimethylsilylation of alcohols with hexamethyldisilazane in the presence of amines and thiols.