氯-1乙氧基甲基-2-苯 | 68578-51-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氯-1乙氧基甲基-2-苯
• 英文名称: chloro-1 ethoxymethyl-2-benzene
• 英文别名: ethyl-(2-chloro-benzyl)-ether；Aethyl-(2-chlor-benzyl)-aether；2-chlorobenzyl ethyl ether；o-Chlorbenzyl-ethyl-ether；1-Chloro-2-(ethoxymethyl)benzene
• CAS: 68578-51-8
• 化学式: C₉H₁₁ClO
• 分子量: 170.639
• InChiKey: WPAGBONHLZEYLC-UHFFFAOYSA-N

物化性质

• 沸点：
  103 °C(Press: 8 Torr)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 、 乙醇 作用下， 生成 氯-1乙氧基甲基-2-苯
  参考文献：
  名称：

  Leonard, Journal of the Chemical Society, 1916, vol. 109, p. 571

  摘要：

  DOI：

文献信息

• Highly efficient indium-catalyzed chemoselective allylation–etherification and reductive etherification of aromatic aldehydes with functional silanes
  作者：Ming-Song Yang、Li-Wen Xu、Hua-Yu Qiu、Guo-Qiao Lai、Jian-Xiong Jiang

  DOI：10.1016/j.tetlet.2007.11.062

  日期：2008.1

  Indium(III) chloride is an effective Lewis acid catalyst for one-pot allylation–etherification and reductive etherification of aromatic aldehydes with functional silanes, allyltriethoxysilane, and triethoxysilane, at room temperature to afford corresponding ethers in excellent yields. Additionally, the InCl3-catalyzed reactions in the presence of TMSCl offer significant advantages in its ease of working-up

  氯化铟（III）是一种有效的路易斯酸催化剂，可在室温下一锅化芳族醛与官能硅烷，烯丙基三乙氧基硅烷和三乙氧基硅烷的烯丙基化—醚化和还原醚化，从而以优异的收率提供相应的醚。另外，在TMSC1存在下，InCl 3催化的反应提供了明显的优点，因为其易于处理以在温和条件下制备不对称醚。
• [EN] PREPARATION OF QUETIAPINE<br/>[FR] PREPARATION DE QUETIAPINE
  申请人：FERMION OY

  公开号：WO2005028457A1

  公开（公告）日：2005-03-31

  The present invention discloses a process for the preparation of quetiapine, which comprises the reaction of dibenzo[b,f][1,4]thiazepin-11-ylamine with a compound of the general formula (II) as well as novel intermediates in the process.

  本发明公开了一种制备喹硫平的方法，包括二苯并[b,f][1,4]噻吩-11-基胺与一般式（II）化合物的反应，以及该过程中的新中间体。
• Preparation of bidentate ligands
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0375576A1

  公开（公告）日：1990-06-27

  A process is disclosed for preparing bidentate ligands of the formula: wherein: each of Ar, R′, R˝ and Y are specifically defined species; the x bonds and the y bonds are attached to adjacent carbon atoms on the ring structures; and n is a whole number in the range of 0-4 where Ar is phenyl: 0-6 where Ar is naphthyl: and 0-8 where Ar is phenanthryl or anthracenyl. The invention process comprises a. reductively coupling an ortho-substituted aromatic moiety to produce a biphenyl compound; b. contacting the biphenyl compound produced in Step (a) with an anion having the structure: wherein Y, Y′ and R′ are specifically defined species; under conditions appropriate to form said bidentate ligand or the dioxide precursor thereof; and c. optionally reducing the intermediate product when the oxy-anion, is employed as the anion in Step (b).

  本发明公开了一种制备双取代配体的方法，其化学式为：其中：Ar、R'、R˝和Y分别是特定定义的物种；x键和y键连接在环结构上相邻的碳原子上；n是整数，在Ar为苯基时为0-4，在Ar为萘基时为0-6，在Ar为菲基或蒽基时为0-8。该发明方法包括：a. 还原偶氮苯衍生物，以产生联苯化合物；b. 将步骤(a)中产生的联苯化合物与具有以下结构的负离子接触：其中Y、Y'和R'是特定定义的物种；在适当的条件下形成所述双取代配体或其二氧化物前体；c. 当氧负离子在步骤(b)中作为负离子时，可选择性地还原中间产物。
• Preparation of biaryl compounds
  申请人：EASTMAN CHEMICAL COMPANY

  公开号：EP0366573A1

  公开（公告）日：1990-05-02

  A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide under conditions suitable to form a Grignard reagent and thereafter contacting the Grignard reagent with an aryl chloride in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternate embodiment of the present invention, biaryl compounds are prepared directly from aryl halides in a single reaction vessel by contacting aryl halide with elemental magnesium and a nickel catalyst comprising a nickel compound and a coordinating ligand in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of biaryl compound.

  本发明公开了一种制备双芳基化合物的方法，该方法包括在适合形成格氏试剂的条件下，使芳基卤化物与格氏试剂接触，然后在适合形成双芳基化合物的条件下，在由镍化合物和配位配体组成的催化剂存在下，使格氏试剂与芳基氯化物接触。在本发明的另一个实施方案中，在单个反应容器中直接从芳基卤化物制备双芳基化合物，方法是在适合于形成双芳基化合物的时间和条件下，在非烷基、非极性、含醚溶剂体系中，使芳基卤化物与元素镁和由镍化合物和配位配体组成的镍催化剂接触。
• HIV REPLICATION INHIBITOR
  申请人：Shionogi & Co., Ltd.

  公开号：EP2772480A1

  公开（公告）日：2014-09-03

  The present invention provides a novel compound having an antiviral action, in particular, an HIV replication inhibiting action, as well as a pharmaceutical composition, in particular, an anti-HIV agent. wherein, a broken line means the presence or absence of a bond; R1 is substituted or unsubstituted alkyl etc., R2 is substituted or unsubstituted alkyloxy etc.; n is 1 or 2; R3 is a substituted or unsubstituted aromatic carbocyclic group; R4 is a hydrogen atom etc.; R5 is a substituted or unsubstituted aromatic carbocyclic group etc.; Y is a single bond etc.; R6 is substituted or unsubstituted alkyl; R7 is -Z-R71 etc.; Z is - NR72-CO- etc.; R71 is substituted or unsubstituted alkyl etc.; R72 is a hydrogen atom etc.

  本发明提供了一种具有抗病毒作用，特别是抑制艾滋病毒复制作用的新型化合物，以及一种药物组合物，特别是一种抗艾滋病毒制剂。 其中，断线表示存在或不存在键；R1 是取代或未取代的烷基等、R2 是取代或未取代的烷氧基等；n 是 1 或 2；R3 是取代或未取代的芳香族碳环基团；R4 是氢原子等；R5 是取代或未取代的芳香族碳环基团等；Y 是单键等；R6 是取代或未取代的烷基；R7 是-Z-R71 等；Z 是-NR72-CO- 等；R71 是取代或未取代的烷基等；R72 是氢原子等。