(1,3-dioxan-2-ylmethyl)triphenylphosphonium bromide | 73022-37-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1,3-dioxan-2-ylmethyl)triphenylphosphonium bromide
• 英文别名: [(1,3-Dioxan-2-yl)methyl](triphenyl)phosphanium bromide；1,3-dioxan-2-ylmethyl(triphenyl)phosphanium;bromide
• CAS: 73022-37-4
• 化学式: Br*C₂₃H₂₄O₂P
• 分子量: 443.32
• InChiKey: SIXFAAOXDKTBRO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.75
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1,3-dioxan-2-ylmethyl)triphenylphosphonium bromide 在 氢氧化钾 、 正丁基锂 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成 (6R)-10'-Apo-15,15'-didehydro-ε-carotin-10'-al-trimethylenacetal
  参考文献：
  名称：

  合成羟基类胡萝卜素和羟丙基甲基丙烯酸酯，合成希尔夫·冯·乙烯基-阴离子（Shapiro - Reaktion）

  摘要：

  夏皮罗反应生成的乙烯基阴离子合成羟甲基类胡萝卜素

  DOI：

  10.1002/hlca.19830660418

文献信息

• Multivalent polyglycerol supported imidazolidin-4-one organocatalysts for enantioselective Friedel–Crafts alkylations
  作者：Tommaso Pecchioli、Manoj Kumar Muthyala、Rainer Haag、Mathias Christmann

  DOI：10.3762/bjoc.11.83

  日期：——

  The first immobilization of a MacMillan’s first generation organocatalyst onto dendritic support is described. A modified tyrosine-based imidazolidin-4-one was grafted to a soluble high-loading hyperbranched polyglycerol via a copper-catalyzed alkyne–azide cycloaddition (CuAAC) reaction and readily purified by dialysis. The efficiency of differently functionalized multivalent organocatalysts 4a–c was tested in the asymmetric Friedel–Crafts alkylation of N-methylpyrrole with α,β-unsaturated aldehydes. A variety of substituted enals was investigated to explore the activity of the catalytic system which was also compared with monovalent analogues. The catalyst 4b showed excellent turnover rates and no loss of activity due to immobilization, albeit moderate enantioselectivities were observed. Moreover, easy recovery by selective precipitation allowed the reuse of the catalyst for three cycles.

  首次将MacMillan的第一代有机催化剂固定在树枝状载体上。一种改性的基于酪氨酸的咪唑啉-4-酮通过铜催化的炔烃-叠氮化物环加成反应（CuAAC）被嫁接到可溶的高负载超支化聚甘油上，并通过透析轻松纯化。测试了不同功能化的多价有机催化剂4a-c在N-甲基吡咯与α,β-不饱和醛的不对称Friedel–Crafts烷基化反应中的效率。研究了多种取代的烯醛，以探索催化系统的活性，并将其与单价类似物进行了比较。催化剂4b显示出优秀的转化率，并且由于固定化而未损失活性，尽管观察到适中的对映选择性。此外，通过选择性沉淀的简易回收使得催化剂可以循环使用三次。

• 一类β-半乳糖苷酶荧光探针、制备方法及其应用
  申请人：华东理工大学

  公开号：CN113801179A

  公开（公告）日：2021-12-17

  本发明公开了一类检测β‑半乳糖苷酶的荧光探针、制备方法及其应用，其结构如通式A所示。本发明提供的β‑半乳糖苷酶荧光探针具有多种用途，可以用于体外、细胞、组织器官及动物水平β‑半乳糖苷酶的传感检测，识别β‑半乳糖苷酶后荧光发射范围从绿光到近红外光(445–662nm)。本发明提供的部分β‑半乳糖苷酶荧光探针具有种属选择性，可以正常识别人源β‑半乳糖甘酶，不受细菌种属β‑半乳糖苷酶的干扰。本发现提供了一种快速、灵敏、多色并且具有种属特异性的β‑半乳糖苷酶荧光探针，在生物分子检测领域具有广阔的应用前景。
• Novel polyprenyl compounds, method of producing the same and their use in dolichol production
  申请人：KURARAY CO., LTD.

  公开号：EP0087136A2

  公开（公告）日：1983-08-31

  There are provided polyprenyl compounds of the formula wherein represent a trans-isoprene unit and a cis-isoprene unit, respectively, n is an integer of 11-19, Z1 and Z2 together represent =0, =CH-COOH, =CH-COOR1, =CH-CN, =C(CN)COOR2, =CH-CO-NH2, =CH-CO-N(R3) (R4), =CH-CO-NHR5, =CH-CH2-N(R3) (R4), =CH-CH2-NHR5 or -CH-CHO or Z1 is a hydrogen atom and Z2 is -CH2COOH, -CH2COOR6, -CH(CN)COOR2, -CH2CN, -CH2-CO-NH2, -CH=CH-N(R3) (R4) or -CH2-CH=N-R6, R1, R2 and R6 each being a lower alkyl group, R3 and R4 each independently being a lower-alkyl, cycloalkyl, aryl or aralkyl group or R3 and R4 together representing an alkylene group containing 2-5 carbon atoms, and R5 being a lower-alkyl, cycloalkyl, aryl or aralkyl group. These polyprenyl compounds can be synthesized starting with a polyprenol obtainable from leaves of a plant such as Ginkgo biloba or Cedrus deodara by extraction and if necessary followed by hydrolysis or a reactive derivative thereof. The polyprenyl compounds are useful as intermediates for the synthesis of dolichols without the use of an expensive C5 chain extender.

  提供了如下式子的聚丙烯化合物 其中 分别代表反式异戊二烯单元和顺式异戊二烯单元，n 是 11-19 的整数，Z1 和 Z2 一起代表＝0、＝CH-COOH、＝CH-COOR1、＝CH-CN、=C(CN)COOR2、=CH-CO-NH2、=CH-CO-N(R3) (R4)、=CH-CO-NHR5、=CH-CH2-N(R3) (R4)、=CH-CH2-NHR5 或 -CH-CHO 或 Z1 是氢原子，Z2 是 -CH2COOH、-CH2COOR6、-CH(CN)COOR2、-CH2CN、-CH2-CO-NH2、-CH=CH-N(R3) (R4) 或 -CH2-CH=N-R6，其中 R1、R2 和 R6 各自为低级烷基，R3 和 R4 各自独立地为低级烷基、环烷基、芳基或芳烷基，或 R3 和 R4 共同代表含有 2-5 个碳原子的亚烷基，R5 为低级烷基、环烷基、芳基或芳烷基。这些聚芘化合物可以从银杏叶或雪松叶等植物叶片中提取的聚芘醇开始合成，必要时还可以通过水解或其反应衍生物合成。这种聚戊烯醇化合物可作为合成多羟基化合物的中间体，而无需使用昂贵的 C5 扩链剂。
• Liquid crystal compound having chroman ring, liquid crystal composition comprising the compound and liquid crystal display device comprising the composition
  申请人：Chisso Corporation

  公开号：EP1674550A1

  公开（公告）日：2006-06-28

  The present invention relates to a compound having a chroman ring, which has good thermal and optical stability, adequate optical anisotropy, adequate dielectric anisotropy and superior compatibility with other liquid crystal compounds, a liquid crystal composition comprising the compound, and a liquid crystal device comprising the composition. A compound represented by formula (1) below is provided: where Ra is hydrogen or C1-C20 alkyl; Rb is halogen, -CN, alkyl, alkenyl or alkoxy; each of A1, A2, A3 and A4 is independently 1,4-cyclohexylene, 1,4-cyclohexenylene or 1,4-phenylene, in which any -CH2- may be replaced by -O- or -S-, any -CH= may be replaced by -N=, and any hydrogen may be replaced by halogen, methyl or -CF3; each of Z1, Z2, Z3 and Z4 is independently a single bond or C1-C4 alkylene; each of h, k, m and n is independently 0, 1 or 2, the sum of h, k, m and n being 1, 2 or 3; and Q is one of the group represented by formulas (q1), (q2) and (q3) below: where X1 is hydrogen or halogen; and each of Y1, Y2, Y3, Y4 and Y5 is independently hydrogen, halogen or methyl.

  本发明涉及一种具有色环的化合物，该化合物具有良好的热稳定性和光学稳定性、足够的光学各向异性、足够的介电各向异性以及与其他液晶化合物优异的兼容性；一种包含该化合物的液晶组合物；以及一种包含该组合物的液晶装置。 本发明提供了由下式（1）表示的化合物： 其中 Ra 是氢或 C1-C20 烷基；Rb 是卤素、-CN、烷基、烯基或烷氧基；A1、A2、A3 和 A4 中的每一个独立地是 1,4-环己烯、1,4-环己烯或 1,4-亚苯基，其中任何 -CH2- 可被 -O- 或 -S- 取代，任何 -CH= 可被 -N= 取代，任何氢可被卤素、甲基或 -CF3 取代；Z1、Z2、Z3 和 Z4 中的每一个独立地为单键或 C1-C4 亚烷基；h、k、m 和 n 中的每一个独立地为 0、1 或 2，h、k、m 和 n 的总和为 1、2 或 3；以及 Q 为下式 (q1)、(q2) 和 (q3) 所代表的基团之一： 其中 X1 是氢或卤素；Y1、Y2、Y3、Y4 和 Y5 各自独立地是氢、卤素或甲基。
• MOLDED ARTICLE AND PRODUCTION METHOD THEREFOR
  申请人：Toray Industries, Inc.

  公开号：EP3653663A1

  公开（公告）日：2020-05-20

  The present invention addresses the problem of providing a fiber-reinforced composite material molded article which exhibits excellent viscosity stability with regards to a resin composition for coating at a low temperature (50°C) after mixing, takes a short period of time to cure when forming a coating, and has excellent surface appearance. This molded article has a coating formed by having a resin composition cure on the surface of a fiber-reinforced composite material. The resin composition contains [A] an aliphatic epoxy resin, [B] a thiol compound, and [C] a quaternary phosphonium salt.

  本发明要解决的问题是提供一种纤维增强复合材料模塑制品，该制品在低温（50°C）混合后，涂覆用树脂组合物的粘度稳定性极佳，形成涂层时固化时间短，且表面外观极佳。这种成型品的涂层是通过在纤维增强复合材料表面固化树脂组合物形成的。树脂组合物包含 [A] 脂肪族环氧树脂、[B] 硫醇化合物和 [C] 季鏻盐。