4-chloro-5-<4-(2-phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone | 150800-39-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-chloro-5-<4-(2-phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone
• 英文别名: 5-chloro-4-[4-(2-phenoxyethyl)piperazin-1-yl]-1H-pyridazin-6-one
• CAS: 150800-39-8
• 化学式: C₁₆H₁₉ClN₄O₂
• 分子量: 334.805
• InChiKey: GFCGRYPRGBTGOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-chloro-5-<4-(2-phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone 、 二溴甲烷 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以25%的产率得到1,1-bis-<2-(4-chloro)-5-<4-(phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinonyl>methane
  参考文献：
  名称：

  Novel and highly selective postsynaptic α-adrenoreceptor antagonists: synthesis and structure-activity relationships of alkane-bridged [4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones

  摘要：

  The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones is reported, The blocking activity of these compounds was determined on the pre- and postsynaptic a-adrenoreceptors of isolated rat vas deferens.

  DOI：

  10.1016/0223-5234(96)88211-0
• 作为产物：
  描述：

  4-chloro-5-(piperazin-1-yl)-2,3-dihydropyridazin-3-one 、 2-氯苯乙醚 在 sodium carbonate 作用下， 以 异戊醇 为溶剂， 以30%的产率得到4-chloro-5-<4-(2-phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone
  参考文献：
  名称：

  New pyridazinones: synthesis and correlation between structure and α-blocking activity

  摘要：

  The synthesis of a series of 5-(4-piperazinyl)-3(2H)-pyridazinone has been reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoreceptors of isolated rat vas deferens.

  DOI：

  10.1016/0223-5234(93)90097-x

文献信息

• New pyridazinones: synthesis and correlation between structure and α-blocking activity
  作者：S Corsano、R Scapicchi、G Strappaghetti、G Marucci、F Paparelli

  DOI：10.1016/0223-5234(93)90097-x

  日期：1993.1

  The synthesis of a series of 5-(4-piperazinyl)-3(2H)-pyridazinone has been reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoreceptors of isolated rat vas deferens.
• Novel and highly selective postsynaptic α-adrenoreceptor antagonists: synthesis and structure-activity relationships of alkane-bridged [4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones
  作者：S Corsano、R Scapicchi、G Strappaghetti、G Marucci、F Paparelli

  DOI：10.1016/0223-5234(96)88211-0

  日期：1995.1

  The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones is reported, The blocking activity of these compounds was determined on the pre- and postsynaptic a-adrenoreceptors of isolated rat vas deferens.