1,1-bis-<2-(4-chloro)-5-<4-(phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinonyl>pentane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,1-bis-<2-(4-chloro)-5-<4-(phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinonyl>pentane
• 英文别名: 4-Chloro-2-[5-[5-chloro-6-oxo-4-[4-(2-phenoxyethyl)piperazin-1-yl]pyridazin-1-yl]pentyl]-5-[4-(2-phenoxyethyl)piperazin-1-yl]pyridazin-3-one
• 化学式: C₃₇H₄₆Cl₂N₈O₄
• 分子量: 737.729
• InChiKey: GVMONXVVENBNBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  51
• 可旋转键数：
  16
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  96.8
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1,5-二溴戊烷 、 4-chloro-5-<4-(2-phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以30%的产率得到1,1-bis-<2-(4-chloro)-5-<4-(phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinonyl>pentane
  参考文献：
  名称：

  Novel and highly selective postsynaptic α-adrenoreceptor antagonists: synthesis and structure-activity relationships of alkane-bridged [4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones

  摘要：

  The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones is reported, The blocking activity of these compounds was determined on the pre- and postsynaptic a-adrenoreceptors of isolated rat vas deferens.

  DOI：

  10.1016/0223-5234(96)88211-0

文献信息

• Novel and highly selective postsynaptic α-adrenoreceptor antagonists: synthesis and structure-activity relationships of alkane-bridged [4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones
  作者：S Corsano、R Scapicchi、G Strappaghetti、G Marucci、F Paparelli

  DOI：10.1016/0223-5234(96)88211-0

  日期：1995.1

  The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones is reported, The blocking activity of these compounds was determined on the pre- and postsynaptic a-adrenoreceptors of isolated rat vas deferens.